Microbiota-immune-brain interactions: A lifespan perspective

Ratsika, Anna; Pereira, Joana S. Cruz; Lynch, Catherine; Clarke, Gerard; Cryan, John F.

doi:10.1016/j.conb.2022.102652

Cited by 38 publications

(30 citation statements)

References 131 publications

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“…Higher concentrations of SCFAs were observed in CA and OC groups, which suggested that CA and OC intervention might be more beneficial for maintaining intestinal homeostasis and inhibiting D-galactose-induced inflammation and oxidative stress. The alterations of SCFAs were highly associated with the changes in gut microbiota following the different interventions, and this association also previously demonstrated the influence on regulation of the immune system 21 and neuroinflammation. 22 Effect of consumption of de-branched starch-fatty acid complexes on intestinal microbial flora Results in Fig.…”

Section: Determination Of Scfas In Fecessupporting

confidence: 60%

Impact of de‐branched starch molecules and fatty acid complexes on the attenuation of ageing‐induced cognitive impairment

et al. 2023

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BACKGROUND Ageing and associated cognitive impairments are becoming serious issues around the world. In this study, the physiological properties of three kinds of complexes of fatty acid (capric, stearic and oleic acid, respectively) and de‐branched starch molecules were investigated via a d‐galactose‐induced ageing model. This study revealed differences in the regulation of cognitive impairment and brain damage following intervention of different complexes, which might highlight a potent approach for the prevention of this chronic disease. RESULTS Data indicated that three complexes improved response time and cognitive function and the bio‐parameter markers associated with oxidative stress in ageing rats. Among them, the complexes prepared from de‐branched starch–oleic acid showed a greater improvement compared to others. In addition, de‐branched starch–capric acid complex showed a higher improvement in the morphology of colon cells and hippocampal neuronal cells. The consumption of de‐branched starch–capric acid and –oleic acid complexes generated more short‐chain fatty acids in the gut. More importantly, the complexation of de‐branched starch with either caprate or stearate enhanced gut Akkermansia. Therefore, it was proposed that the richness in Akkermansia and gut metabolites might be associated with reduced damage of the hippocampal neuronal cells induced by the ageing progress. Moreover, the AMPK (AMP‐activated protein kinase) pathway was activated in liver in de‐branched starch–capric acid complex diet. In summary, de‐branched starch–capric acid complex exhibited a greater effect on the attenuation of ageing‐induced cognitive impairment. CONCLUSION This study might highlight a new approach for intervening in the cognitive impairment during the ageing progress via a food supply. © 2023 Society of Chemical Industry.

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Section: Determination Of Scfas In Fecessupporting

confidence: 60%

Impact of de‐branched starch molecules and fatty acid complexes on the attenuation of ageing‐induced cognitive impairment

et al. 2023

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“…These MAMPs are recognized by toll-like receptors (TLRs) to activate the various immune cells to generate pro-inflammatory cytokines such asIL1β, IL6, TNF-α, and IL17 that enter the brain through the blood–brain barrier and cause neurological disorders [ 55 ]. During dysbiosis in the GIT, the GM modulate the inflammatory metabolism, primarily by releasing various inflammatory cytokines, including IL-4, IL-10, and IFN-y, through their immune system [ 56 , 57 ]. Irritable bowel syndrome (IBS) is well defined by ENS dysregulation, which results in irregular microbial populations, activation of mucosal innate immune responses, increased gut epithelial permeability, and activation of gut sensory and epithelial permeability pathways [ 42 , 58 ].…”

Section: Neurology Pathway In Gbamentioning

confidence: 99%

Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance

Tiwari

Dwivedi

Bansal

et al. 2023

JCM

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In humans, the gut microbiota (GM) are known to play a significant role in the metabolism of nutrients and drugs, immunomodulation, and pathogen defense by inhabiting the gastrointestinal tract (GIT). The role of the GM in the gut–brain axis (GBA) has been documented for different regulatory mechanisms and associated pathways and it shows different behaviors with individualized bacteria. In addition, the GM are known as susceptibility factor for neurological disorders in the central nervous system (CNS), regulating disease progression and being amenable to intervention. Bidirectional transmission between the brain and the GM occurs in the GBA, implying that it performs a significant role in neurocrine, endocrine, and immune-mediated signaling pathways. The GM regulates multiple neurological disorders by supplementing them with prebiotics, probiotics, postbiotics, synbiotics, fecal transplantations, and/or antibiotics. A well-balanced diet is critically important for establishing healthy GM, which can alter the enteric nervous system (ENS) and regulate multiple neurological disorders. Here, we have discussed the function of the GM in the GBA from the gut to the brain and the brain to the gut, the pathways associated with neurology that interacts with the GM, and the various neurological disorders associated with the GM. Furthermore, we have highlighted the recent advances and future prospects of the GBA, which may require addressing research concerns about GM and associated neurological disorders.

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“…The current state of the art suggests an important communication between the residing intestinal microorganisms, brain development, function, and behavior associated with psychiatric disorders [ [1] , [2] , [3] , [4] , [5] , [6] ]. The concept known as the microbiota-gut-brain axis is now widely accepted [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] ]. In neuroscience, the number of studies on the interactions between the brain, gastrointestinal tract, gut bacteria, and the bidirectional relationship between these systems is steadily increasing, including manipulation of gut microbial diversity by novel prebiotics as potential alternative therapeutic possibilities for the treatment of neurodevelopmental disorders [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide

Tejkalová¹,

Jakob²,

Kvasnová³

et al. 2023

Heliyon

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Microbiota-immune-brain interactions: A lifespan perspective

Cited by 38 publications

References 131 publications

Impact of de‐branched starch molecules and fatty acid complexes on the attenuation of ageing‐induced cognitive impairment

Impact of de‐branched starch molecules and fatty acid complexes on the attenuation of ageing‐induced cognitive impairment

Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance

The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide

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