Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches

Abstract

This comprehensive review article delves into the critical role of the human microbiota in the development and management of endocrine-related diseases. We explore the complex interactions between the microbiota and the endocrine system, emphasizing the implications of microbiota dysbiosis for the onset and progression of various endocrine disorders. The review aims to synthesize current knowledge, highlighting recent advancements and the potential of novel therapeutic approaches targeting microbiota-endocrine interactions. Key topics include the impact of microbiota on hormone regulation, its role in endocrine pathologies, and the promising avenues of microbiota modulation through diet, probiotics, prebiotics, and fecal microbiota transplantation. We underscore the importance of this research in advancing personalized medicine, offering insights for more tailored and effective treatments for endocrine-related diseases.

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

“…These include tryptophan, γ-aminobutyric acid (GABA), histamine, serotonin, short-chain fatty acids (SCFAs), 5-hydroxytryptamine (5-HT, serotonin), dopamine, and acetylcholine (ACh) [44,45]. The multifaceted action of microbial metabolites exerts an influence on diverse mechanisms essential for maintaining mental state, including maturation of the immune [46] and neuroendocrine systems [47], regulation of nutrient metabolism, and facilitation of xenobiotic transformation [48]. Moreover, microbial metabolites play a pivotal role in safeguarding the integrity of the gut barrier, enhancing the resilience of the mucosal layer, and impeding the infiltration of harmful pathogens and toxins into the bloodstream [49].…”