Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics

Белобородова, Н. В.; Pautova, Alisa; Grekova, Marina; Yadgarov, M. Yа.; Grin, Oksana; Еременко, А А; Бабаев, М А

doi:10.3390/biomedicines11051335

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…p-HPhLA is described as having prognostic significance in cases of infectious complications and sepsis; its values can increase ten-fold. [14]. Meta-analysis showed that the risk of death was 1.5 times higher in patients experiencing severe postoperative complications (Clavien-Dindo ≥ III) than in patients without severe complications [3].…”

Section: Discussionmentioning

confidence: 99%

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Blood Serum and Drainage Microbial and Mitochondrial Metabolites in Patients after Surgery for Pancreatic Cancer

Getsina,

Tsyba,

Polyakov

et al. 2023

Metabolites

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Pancreatic cancer (PC) has the highest mortality rate of all major cancers in the world despite improvements in clinical care and an understanding of the biology of pancreatic cancer. A study of 64 patients with verified pancreatic cancer who underwent surgery was included. Sampling was carried out at three points: before surgery and on days 1–3 after surgery and 5–7 days after surgery. Drainage fluid collection was taken from the drains installed intraoperatively one day after surgery. Tyrosine and phenylalanine metabolites and two mitochondrial metabolites, namely succinic and fumaric acids, were identified and quantified by GC-MS in the serum of healthy donors and patients. Differences in the metabolomic profile were found between the patients and healthy people. A statistically significant decrease in the level of p-hydroxyphenyllactic acid (p-HPhLA), the amount of sum 3 sepsis-associated metabolites (Σ 3AMM), as well as fumaric and succinic acids in patients was observed. It was also noted that p-hydroxyphenyllactic acid in the preoperative period may be considered as a predictor of complications and longer postoperative recovery.

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Section: Discussionmentioning

confidence: 99%

“…[12,13]. One of the promising markers for monitoring infectious complications in surgical patients, reflecting microbiota dysfunction, could be aromatic microbial metabolites, but their role in cancer has not been studied [14,15].…”

Section: Introductionmentioning

confidence: 99%

Blood Serum and Drainage Microbial and Mitochondrial Metabolites in Patients after Surgery for Pancreatic Cancer

Getsina,

Tsyba,

Polyakov

et al. 2023

Metabolites

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An Integrated Approach Based on Clinical Data Combined with Metabolites and Biomarkers for the Assessment of Post-Operative Complications after Cardiac Surgery

Meinarovich,

Pautova,

Zuev

et al. 2024

JCM

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Background: Early diagnosis of post-operative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. The purpose of this study was to determine whether an integrated approach based on clinical data, along with metabolites and biomarkers, had greater predictive value than the models built on fewer data in the early diagnosis of post-operative complications after cardiac surgery. Methods: The study included patients (n = 62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass) with (n = 26) or without (n = 36) post-operative complications. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients’ blood samples were collected before and on the first day after surgery to determine biomarkers and metabolites. Results: Multivariate PLS-DA models, predicting the presence or absence of post-operative complications, were built using clinical data, concentrations of metabolites and biomarkers, and the entire data set (ROC-AUC = 0.80, 0.71, and 0.85, respectively). For comparison, we built univariate models using the EuroScore2 and SOFA scales, concentrations of lactate, the dynamic changes of 4-hydroxyphenyllactic acid, and the sum of three sepsis-associated metabolites (ROC-AUC = 0.54, 0.79, 0.62, 0.58, and 0.70, respectively). Conclusions: The proposed complex model using the entire dataset had the best characteristics, which confirms the expediency of searching for new predictive models based on a variety of factors.

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Degermação cirúrgica das mãos da equipe de cirurgia cardíaca: uma análise microbiológica

Pinto,

Henrique,

Fassarella

et al. 2024

Rev SOBECC

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Objetivo: Descrever a microbiota das mãos da equipe de cirurgia cardíaca após a degermação cirúrgica das mãos e a retirada das luvas ao término do procedimento cirúrgico, e comparar com a adesão ao tempo correto de degermação cirúrgica. Método: Estudo observacional realizado em dois momentos: após degermação cirúrgica das mãos da equipe de cirurgia cardíaca e após a retirada das luvas ao término do procedimento cirúrgico. As variáveis analisadas foram de identificação dos profissionais e aspectos da degermação cirurgica das mãos. O instrumento de coleta de dados contou com um roteiro de observação, com base na literatura. Resultados: Vinte profissionais foram observados, resultando em 40 amostras. Nos dois momentos de coleta, foram identificados microrganismos da microbiota residente da pele, como Staphylococcus coagulase negativa, Staphylococcus aureus sensível à meticilina, Bacillus sp em 35% (7) da equipe cirúrgica. Houve isolamento de microrganismos potencialmente relacionados à infecção de sítio cirúrgico, Escherichia coli, Klebsiella pneumoniae e Proteus mirabilis em 25% (5) da população estudada. O risco da presença de microrganismo patogênico quando a degermação cirurgica das mãos não é realizada no tempo recomendado foi de 14,2%. Conclusão: estratégias para adesão à técnica correta e ao treinamento periódico de degermação das mãos devem ser implementadas para mitigar a ocorrência de infecção de sítio cirúrgico e segurança do paciente.

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Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics

Cited by 3 publications

References 33 publications

Blood Serum and Drainage Microbial and Mitochondrial Metabolites in Patients after Surgery for Pancreatic Cancer

Blood Serum and Drainage Microbial and Mitochondrial Metabolites in Patients after Surgery for Pancreatic Cancer

An Integrated Approach Based on Clinical Data Combined with Metabolites and Biomarkers for the Assessment of Post-Operative Complications after Cardiac Surgery

Degermação cirúrgica das mãos da equipe de cirurgia cardíaca: uma análise microbiológica

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