Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

Wu, Wei; Sun, Mingming; Chen, F.; Cao, Anthony; Liu, H.; Zhao, Ye; Huang, Xiangsheng; Xiao, Yi; Yao, Suxia; Zhao, Qihong; Liu, Zhe; Cong, Yingzi

doi:10.1038/mi.2016.114

Cited by 354 publications

(228 citation statements)

References 47 publications

Supporting

Mentioning

225

Contrasting

Order By: Relevance

“…In two separate studies, acetate was found to affect CD103 + dendritic cell retinol dehydrogenase activity resulting in increased retinoic acid (RA) production, which increased intestinal IgA production [66,76]. In two separate studies, acetate was found to affect CD103 + dendritic cell retinol dehydrogenase activity resulting in increased retinoic acid (RA) production, which increased intestinal IgA production [66,76].…”

Section: Effect Of Commensal Metabolites On Host Immune Functionmentioning

confidence: 99%

Metabolism at the centre of the host–microbe relationship

Maslowski

2019

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Summary Maintaining homoeostatic host–microbe interactions is vital for host immune function. The gut microbiota shapes the host immune system and the immune system reciprocally shapes and modifies the gut microbiota. However, our understanding of how these microbes are tolerated and how individual, or communities of, gut microbes influence host function is limited. This review will focus on metabolites as key mediators of this complex host–microbe relationship. It will look at the central role of epithelial metabolism in shaping the gut microbiota, how microbial metabolites influence the epithelium and the mucosal and peripheral immune system, and how the immune system shapes microbial composition and metabolism. Finally, this review will look at how metabolites are involved in cross‐talk between different members of the microbiota and their role during infections.

show abstract

Section: Effect Of Commensal Metabolites On Host Immune Functionmentioning

confidence: 99%

Metabolism at the centre of the host–microbe relationship

Maslowski

2019

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…), promoting B‐cell IgA production (Wu et al . ) and protecting epithelial barrier integrity (Macia et al . ; Zhao et al .…”

Section: Diet‐derived Microbial Metabolites In Health and Diseasementioning

confidence: 99%

“…Thus, SCFAs maintain intestinal homeostasis by regulating differentiation of T cells (Arpaia et al 2013;Furusawa et al 2013;Smith et al 2013;Sun et al 2018), promoting B-cell IgA production (Wu et al 2017) and protecting epithelial barrier integrity (Macia et al 2015;Zhao et al 2018). There is also considerable evidence for direct and indirect effects of SCFAs on the brain (Dalile et al 2019).…”

Section: Short-chain Fatty Acidsmentioning

confidence: 99%

Diet‐derived microbial metabolites in health and disease

Roager

Dragsted

2019

Nutrition Bulletin

View full text Add to dashboard Cite

The gut microbiota helps us digest food and has been associated with both good health and risk of disease. Although compositions of the gut microbiota are highly divergent, the gut microbiota exhibits a high level of functional redundancy making it difficult to reliably link gut microbiome patterns to health and diet across individuals. Thus, there is a need to move beyond profiling of the gut microbial composition to the assessment of gut microbial metabolic activity in order to expand knowledge on the impact of the gut microbiota on health. Metabolomics has already proven its utility in identifying gut‐derived microbial metabolites, which may be mediators of diet‐induced host–microbial crosstalk important for health. These diet‐derived metabolites include, among many others, the short‐chain fatty acids originating from bacterial degradation of dietary fibres and proteins, secondary bile acids derived from primary bile acids, microbial tryptophan catabolites resulting from proteolysis, imidazole propionate produced from histidine and trimethylamine N‐oxide, a host–microbial co‐metabolite of nutrients such as phosphatidylcholine, choline and L‐carnitine, present in high‐fat foods. These co‐metabolites have been associated with beneficial and detrimental effects in the host. However, the vast majority of metabolites measured by untargeted metabolomics in human blood and excreta remain unknown and may include additional microbial molecules of importance for health. Thus, there is great potential, yet to be explored, for identifying additional diet‐derived microbial products that affect the host. Herein, we review key advances, challenges and limitations in our understanding of diet–microbiome interactions and diet‐derived microbial metabolites in relation to human health and discuss how metabolomics may shed light on inter‐individual differences in dietary responses.

show abstract

“…Recently, Kim and colleagues showed that SCFA regulate metabolism and gene expression in B cells, which enhances antibody production (156). Additional studies revealed that acetate influenced vitamin A metabolism via GPR43 signaling in dendritic cells, which ultimately promoted intestinal B cell production of IgA (157). Additional studies are needed to determine if SCFA also impact humoral immunity via HDAC activity.…”

Section: Lipids and Their Impact On Immune Responsesmentioning

confidence: 99%

Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes

Clavel

Gomes-Neto

Lagkouvardos

et al. 2017

Immunological Reviews

106

View full text Add to dashboard Cite

Summary The community of microorganisms in the mammalian gastrointestinal tract, referred to as the gut microbiota, influences host physiology and immunity. The last decade of microbiome research has provided significant advancements for the field and highlighted the importance of gut microbes to states of both health and disease. Novel molecular techniques have unraveled the tremendous diversity of intestinal symbionts that potentially influence the host, many proof-of-concept studies have demonstrated causative roles of gut microbial communities in various pathologies, and microbiome-based approaches are beginning to be implemented in the clinic for diagnostic purposes or for personalized treatments. However, several challenges for the field remain: purely descriptive reports outnumbering mechanistic studies and slow translation of experimental results obtained in animal models into the clinics. Moreover, there is a dearth of knowledge regarding how gut microbes, including novel species that have yet to be identified, impact host immune responses. The sheer complexity of the gut microbial ecosystem makes it difficult, in part, to fully understand the microbiota-host networks that regulate immunity. In the present manuscript, we review key findings on the interactions between gut microbiota members and the immune system. Because culturing microbes allows performing functional studies, we have emphasized the impact of specific taxa or communities thereof. We also highlight underlying molecular mechanisms and discuss opportunities to implement minimal microbiome-based strategies.

show abstract

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

Cited by 354 publications

References 47 publications

Metabolism at the centre of the host–microbe relationship

Metabolism at the centre of the host–microbe relationship

Diet‐derived microbial metabolites in health and disease

Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes

Contact Info

Product

Resources

About