Microbiota modulation and anti-obesity effects of fermented Pyrus ussuriensis Maxim extract against high-fat diet-induced obesity in rats

Boby, Naila; Abbas, Muhammad; Lee, Eon‐Bee; Im, Zi-Eum; Lee, Seung-Jin; Park, Seung-Chun

doi:10.1016/j.biopha.2022.113629

Cited by 7 publications

(10 citation statements)

References 63 publications

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“…Targeting gut microbiota is a viable preventative or therapeutic approach for obesity due to the link between gut bacteria and obesity [ 7 , 25 ]. Curcumin, betaine, garcinol, eugenol, and other dietary components appear to alleviate obesity by modifying the gut flora [ 11 , 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Methyl Cedryl Ether Ameliorates Adiposity in High-Fat Diet-Fed Mice

Kang

Huang

et al. 2023

Nutrients

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Methyl cedryl ether (MCE) is a derivative of cedrol and is widely used as a fragrance compound. The aim of this study was to evaluate the preventative effects of MCE on obesity and related metabolic syndromes and to delineate the mechanisms from the perspective of gut microbiota and white adipose tissues (WAT) transcriptomic profiles. Five-week-old male C57BL/6J mice were randomly assigned into 3 groups and fed with chow diet, high-fat diet (HFD), or HFD supplemented with 0.2% (w/w) MCE for 13 weeks. We found that MCE significantly reduced body weight, inhibited adipocyte hypertrophy, and ameliorated hepatic steatosis under HFD conditions. MCE dietary supplementation downregulated the expression of adipogenesis genes (FAS and C/EBPα) and upregulated the mRNA levels of thermogenesis genes (PGC-1α, PRDM16, UCP1, Cidea, Cytc, and COX4) in epididymal WAT. 16S rRNA sequencing revealed that MCE improved gut microbiota dysbiosis in HFD-fed mice, as manifested by the alteration of strains associated with obesity. Further transcriptome analysis of WAT indicated that MCE dramatically changed the gene expression profiles. Our results demonstrate the anti-obesity effect of MCE under HFD conditions, highlighting the nutraceutical potential of MCE for preventing obesity.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Methyl Cedryl Ether Ameliorates Adiposity in High-Fat Diet-Fed Mice

Kang

Huang

et al. 2023

Nutrients

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“…In addition to causing aberrant lipid metabolism, obesity brought on by a high-fat diet also in ames the body. Since the HFD-induced obesity mice model in our study closely resembles the underlying etiology of obesity in humans, it is regarded as highly translational (Boby et al 2022). Furthermore, the HFD-induced obesity model offers a trustworthy way to investigate obesity since it is easy to make animals gain weight when they are fed a high-fat diet.…”

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confidence: 99%

“…According to our ndings, taking supplements containing S. horneri may help stop excess weight gain without reducing overall food intake, which is linked to weight increase. An excessive increase in adipose tissue mass and the liver can be characterized as obesity (Boby et al 2022). Thus, we measured the mass of adipose tissue and various organs in this study.…”

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confidence: 99%

“…Liver and adipose tissue have signi cant levels of the pro-adipogenic transcription factor SREBP1, which has the ability to directly control the expression of the lipogenic genes FAS and ACC, which are involved in lipid metabolism (Payne et al 2010;Boby et al 2022). The current investigation found that the HFD group had considerably higher levels of SREBP-1, FAS, ACC protein, and mRNA expression, including SCD.…”

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confidence: 99%

“…correlated with the development of the cardiovascular risk factor (CVRF)(Boby et al 2022). As a result, the AI and CVRF values of the groups treated with S. horneri seem advantageous, showing lipid-lowering characteristics linked to a putative cardioprotective effect.…”

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confidence: 99%

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Bioactive compounds from Sargassum horneri attenuates inflammation and obesity regulating by Nrf2/HO-1 and AMPK signaling pathways

Chilakala,

Moon,

Kim

et al. 2024

Preprint

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Sargassum horneri is rich in bioactive compounds, including phytosterols, exhibits antioxidant, anti-obesity and anti-inflammation properties; however, its underlying mechanisms remain unclear. In this study, we evaluated that the antioxidant and anti-inflammatory effect of S. horneri ethanolic extract and its subfractions using lipopolysaccharide (LPS)-treated RAW264.7 cells. Furthermore, we examined the in vivo anti-obesity efficacy of S. horneri using obese mice fed a high-fat diet. Results revealed that the in vitro treatment increases the inflammatory cytokines such as iNOS, NO, COX-2, PGE2, TNF-α, and IL-6 including NF-κB subunit p65 protein expressions in LPS treated RAW264.7 cells. However, these pro-inflammatory cytokines were significantly reduced by inhibiting the NF-κB- p65 translocation pathway in S. horneri treatment. In addition, the S. horneri extracts increased the Nrf2 translocation into the nucleus as well as their heme oxygenase (HO-1) target gene expression. Whereas, in vivo treatment with S. horneri reduces body and organ weight, including pathological damage in liver and adipose tissue. Moreover, S. horneri decreases serum triglycerides (TG), LDL-cholesterol, total cholesterol (TC), arteriosclerosis index (AI), and cardiovascular risk index (CRF), but increases HDL-cholesterol concentration-dependently. The liver antioxidant enzyme activities and AMPK protein expressions were raised in S. horneri treated groups; while SREBP-1, FAS, and ACC expressions was reduced with dose-dependent manner. These findings provide an innovative pharmacological basis for the antioxidant, anti-inflammatory and anti-obesity effect of S. horneri. It specifies the potential of S. horneri as a candidate for preventing inflammation, obesity and other related disorders.

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The anti-obesogenic effects and underpinning mechanisms of fermented plant-based foods: A review

Xiao-wei

Zhou

et al. 2023

Trends in Food Science & Technology

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Microbiota modulation and anti-obesity effects of fermented Pyrus ussuriensis Maxim extract against high-fat diet-induced obesity in rats

Cited by 7 publications

References 63 publications

Dietary Supplementation of Methyl Cedryl Ether Ameliorates Adiposity in High-Fat Diet-Fed Mice

Dietary Supplementation of Methyl Cedryl Ether Ameliorates Adiposity in High-Fat Diet-Fed Mice

Bioactive compounds from Sargassum horneri attenuates inflammation and obesity regulating by Nrf2/HO-1 and AMPK signaling pathways

The anti-obesogenic effects and underpinning mechanisms of fermented plant-based foods: A review

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