Microbiote intestinal et allogreffe de cellules souches hématopoïétiques

Dougé, Aurore; Bay, Jacques‐Olivier; Ravinet, Aurélie; Scanzi, Julien

doi:10.1016/j.bulcan.2019.08.014

Cited by 3 publications

(4 citation statements)

References 63 publications

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“…In line with this hypothesis, we observed a higher incidence of bacterial infections in the complement‐activated group, suggesting a higher use of antibiotics in this group that might have impacted the microbiota. Several studies have reported microbiota dysbiosis in patients undergoing HSCT characterized by a higher proportion of Enterococcus, Enterobacteriaceae, Clostridial bacteria, proteobacteria, and a decrease of Blautia Genus 46–49 . Patients with an important loss of microbiota diversity have a higher risk of NRM due to a high incidence of GI GVHD 47 .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported microbiota dysbiosis in patients undergoing HSCT characterized by a higher proportion of Enterococcus, Enterobacteriaceae, Clostridial bacteria, proteobacteria, and a decrease of Blautia Genus. [46][47][48][49] Patients with an important loss of microbiota diversity have a higher risk of NRM due to a high incidence of GI GVHD. 47 Interestingly, bacteria-like Enterococcus can lead to the activation of classical complement pathway, 50 whereas other species, such as Enterobacteria, produce LPS and favors the complement lectin pathway activation.…”

Section: Endothelial Complications Infections and Complement Activationmentioning

confidence: 99%

“…[46][47][48][49] Patients with an important loss of microbiota diversity have a higher risk of NRM due to a high incidence of GI GVHD. 47 Interestingly, bacteria-like Enterococcus can lead to the activation of classical complement pathway, 50 whereas other species, such as Enterobacteria, produce LPS and favors the complement lectin pathway activation. Therefore, it would be of interest to analyze gut microbiota diversity and dysbiosis in transplanted patients and correlate the results to complement activation.…”

Section: Endothelial Complications Infections and Complement Activationmentioning

confidence: 99%

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Systemic complement activation influences outcomes after allogeneic hematopoietic cell transplantation: A prospective French multicenter trial

et al. 2023

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Complement activation has shown a role in murine models of graft‐versus‐host disease (GVHD) and in endothelial complications after allogeneic hematopoietic cell transplantation (allo‐HSCT). However, its impact on post‐transplant outcomes has not been so far fully elucidated. Here, we conducted a prospective multicentric trial (NCT01520623) performing serial measurements of complement proteins, regulators, and CH50 activity for 12 weeks after allo‐HSCT in 85 patients receiving a myeloablative conditioning (MAC) regimen for various hematological malignancies. Twenty‐six out of 85 patients showed an “activated” complement profile through the classical/lectin pathway, defined as a post‐transplant decline of C3/C4 and CH50 activity. Time‐dependent Cox regression models demonstrated that complement activation within the first weeks after allo‐HSCT was associated with increased non‐relapse mortality (hazard ratio [HR]: 3.69, 95% confident interval [CI]: 1.55–8.78, p = .003) and poorer overall survival (HR: 2.72, 95% CI: 1.37–5.39, p = .004) due to increased incidence of grade II–IV acute GVHD and in particular gastrointestinal (GI) GVHD (HR: 36.8, 95% CI: 12.4–109.1, p < .001), higher incidences of thrombotic microangiopathy (HR: 8.58, 95% CI: 2.16–34.08, p = .0022), capillary leak syndrome (HR: 7.36, 95% CI: 2.51–21.66, p = .00028), post‐engraftment bacterial infections (HR: 2.37, 95% CI: 1.22–4.63, p = .0108), and EBV reactivation (HR: 3.33, 95% CI: 1.31–8.45, p = .0112). Through specific immune staining, we showed the correlation of deposition of C1q, C3d, C4d, and of C5b9 components on endothelial cells in GI GVHD lesions with the histological grade of GVHD. Altogether these findings define the epidemiology and the clinical impact of complement classical/lectin pathway activation after MAC regimens and provide a rational for the use of complement inhibitory therapeutics in a post‐allo‐HSCT setting.

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Section: Discussionmentioning

confidence: 99%

Section: Endothelial Complications Infections and Complement Activationmentioning

confidence: 99%

Section: Endothelial Complications Infections and Complement Activationmentioning

confidence: 99%

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Systemic complement activation influences outcomes after allogeneic hematopoietic cell transplantation: A prospective French multicenter trial

et al. 2023

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“…A 2014 review explored the published literature for evidence that the GI tract microbiome played a role in this kind of damage ( Touchefeu et al, 2014 ). Owing to these findings, clinicians began to consider the potential of FMT in radiotherapy, where a link was made between the microbiome of the GI tract and success of stem cell transplants for leukemia ( Dougé et al, 2020 ). Results suggested that FMT could be used to rebalance the bacterial composition of the gut, and thereby reduce posttransplant complications.…”

Section: The Effects Of the Microbiome On The Radiation Responsementioning

confidence: 99%

Acute Radiation Syndrome and the Microbiome: Impact and Review

et al. 2021

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Study of the human microbiota has been a centuries-long endeavor, but since the inception of the National Institutes of Health (NIH) Human Microbiome Project in 2007, research has greatly expanded, including the space involving radiation injury. As acute radiation syndrome (ARS) is multisystemic, the microbiome niches across all areas of the body may be affected. This review highlights advances in radiation research examining the effect of irradiation on the microbiome and its potential use as a target for medical countermeasures or biodosimetry approaches, or as a medical countermeasure itself. The authors also address animal model considerations for designing studies, and the potential to use the microbiome as a biomarker to assess radiation exposure and predict outcome. Recent research has shown that the microbiome holds enormous potential for mitigation of radiation injury, in the context of both radiotherapy and radiological/nuclear public health emergencies. Gaps still exist, but the field is moving forward with much promise.

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Distinct profiles of bile acid metabolism caused by gut microbiota in kidney transplantation recipients revealed by 16S rRNA gene sequencing

Tian

Cao

et al. 2023

Archives of Physiology and Biochemistry

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Microbiote intestinal et allogreffe de cellules souches hématopoïétiques

Cited by 3 publications

References 63 publications

Systemic complement activation influences outcomes after allogeneic hematopoietic cell transplantation: A prospective French multicenter trial

Systemic complement activation influences outcomes after allogeneic hematopoietic cell transplantation: A prospective French multicenter trial

Acute Radiation Syndrome and the Microbiome: Impact and Review

Distinct profiles of bile acid metabolism caused by gut microbiota in kidney transplantation recipients revealed by 16S rRNA gene sequencing

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