Microbleeds in fronto-subcortical circuits are predictive of dementia conversion in patients with vascular cognitive impairment but no dementia

Chen, Yang-Kun; Xiao, Weimin; Li, Wei; Ni, Zhuo-Xin; Liu, Yonglin; Xu, Li; Qu, Jian‐Feng; Ng, Chee H.; Xiang, Yu‐Tao

doi:10.4103/1673-5374.239441

Cited by 7 publications

(1 citation statement)

References 32 publications

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“…Microbleeds. These were de ned as small (2-10 mm) hypointense lesions with a clear margin in susceptibilityweighted imaging [26]. Symmetric basal ganglia calci cation and ow void artifacts of the pial blood vessels were excluded.…”

Section: Mri Assessmentsmentioning

confidence: 99%

Effects of Early Neurological Deterioration in Acute Ischemic Stroke on Multiple Dimensions of Functional Outcomes using Propensity Score Matching Analysis

Qu¹,

Zhong²,

Liang³

et al. 2020

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Background: Early neurological deterioration (END) is common in acute ischemic stroke (AIS), but its effect on functional outcomes is not well understood. Here, we explored the effects of END on multiple dimensions of functional outcomes.Methods: 256 patients with AIS were analyzed. All patients were followed up for 1 year. We used the modified Rankin Scale (mRS) to assess body function impairment, the Lawton activities of daily living scale to assess activity limitations, and the reintegration to normal living index (RNLI) to assess participation restrictions. Brain MRI was performed to identify acute infarcts and preexisting abnormalities. To reduce the effects of a lack of randomization, we conducted a propensity score analysis. Results: Among 256 patients with AIS, 61(23.8%) patients had END. Before matching, patients with END had higher levels of small artery-type stroke, higher NIHSS scores on arrival, higher systolic blood pressure on admission, and larger infarct volumes. After matching, there were no significant differences between the two groups in any clinical or neuroimaging variables, except for stroke subtype and cortical region infarct. Logistic regression analysis revealed that END was a significant predictor of poor mRS (odds ratio [OR], 3.829; 95% confidence interval [CI], 1.367–10.723, p = 0.011) and poor RNLI (OR, 2.777; 95% CI, 1.133–6.806, p = 0.026) scores after adjusting for confounding factors.Conclusions: END is relatively common in AIS. END might be a significant predictor of poor functional outcomes, including body function impairment and reduced social participation.

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Section: Mri Assessmentsmentioning

confidence: 99%