Microbubble Formulations: Synthesis, Stability, Modeling and Biomedical Applications

Upadhyay, Awaneesh; Dalvi, Sameer V.

doi:10.1016/j.ultrasmedbio.2018.09.022

Cited by 92 publications

(101 citation statements)

References 272 publications

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“…Currently, microbubbles are also used as drug/gene delivery vehicles, as O 2 gas carriers, for delivery of drugs across the blood–brain barrier and for therapeutic thrombolytic purposes. 37 38 In our current and subsequent studies, the therapeutic possibilities for removal of ductal obstructions will be further investigated. If successful, we plan in subsequent studies to combine microbubbles with therapeutic agents, and aim to enhance drug delivery to the salivary glands and improve outcomes in patients with SS.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative visualisation and treatment of salivary glands in Sjögren’s syndrome by contrast-enhanced ultrasound sialendoscopy (CEUSS): protocol for a phase I single-centre, single-arm, exploratory study

et al. 2020

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IntroductionWe established a promising sialendoscopic treatment for in vivo enhancement of salivation in salivary glands affected by Sjögren’s syndrome (SS). In this technique, the ducts of the salivary glands are irrigated with saline and steroids. This allows for dilatation of ductal strictures and removal of debris. Unfortunately, it is not possible to assess the delivery and penetration of saline or medications in the ductal system and parenchyma. To address this problem, we will conduct contrast-enhanced ultrasound sialendoscopy (CEUSS) using sulphur hexafluoride microbubbles. To the best of our knowledge, microbubbles have never been used for the treatment of salivary glands in SS. It is, therefore, imperative to test this application for its safety and feasibility.Methods and analysisA single-arm phase I study will be performed in 10 SS patients. Under local anaesthesia, ultrasound (US) guided infusion of the parotid and submandibular glands with microbubbles will be performed. Continuous US imaging will be used to visualise the glands, including the location of strictures and occlusions. Main outcomes will be the evaluation of safety and technical feasibility of the experimental treatment. Secondary outcomes will consist of determinations of unstimulated whole mouth saliva flow, stimulated whole mouth saliva flow, stimulated parotid saliva flow, clinical oral dryness, reported pain, xerostomia, disease activity, salivary cytokine profiles and clinical SS symptoms. Finally, salivary gland topographical alterations will be evaluated by US.Ethics and disseminationEthical approval for this study was obtained from the Medical Ethics Committee of the Amsterdam University Medical Centre, Amsterdam, The Netherlands (NL68283.029.19). data will be presented at national and international conferences and published in a peer-reviewed journal. The study will be implemented and reported in line with the Standard Protocol Items: Recommendations for Interventional Trials’ statement.Trial registration numbersThe Netherlands Trial Register: NL7731, MREC Trial Register: NL68283.029.19; Pre-results.

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Section: Discussionmentioning

confidence: 99%

Intraoperative visualisation and treatment of salivary glands in Sjögren’s syndrome by contrast-enhanced ultrasound sialendoscopy (CEUSS): protocol for a phase I single-centre, single-arm, exploratory study

et al. 2020

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“…MBs are common echo-contrast agents used in medical procedures in humans. They typically consist of an inert gaseous bubble encapsulated by a biocompatible material, with lipids being the most common interfacial encapsulant [ 13 , 63 ]. For sonodelivery, MBs can either be fabricated with a protein or gene of interest loaded within the bubble or “empty” bubbles can be complexed with the payload prior to injection [ 64 ].…”

Section: Ultrasound-mediated Gene Delivery In Skeletal Musclementioning

confidence: 99%

Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential

et al. 2020

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There are currently multiple approaches to facilitate gene therapy via intramuscular gene delivery, such as electroporation, viral delivery, or direct DNA injection with or without polymeric carriers. Each of these methods has benefits, but each method also has shortcomings preventing it from being established as the ideal technique. A promising method, ultrasound-mediated gene delivery (or sonodelivery) is inexpensive, widely available, reusable, minimally invasive, and safe. Hurdles to utilizing sonodelivery include choosing from a large variety of conditions, which are often dependent on the equipment and/or research group, and moderate transfection efficiencies when compared to some other gene delivery methods. In this review, we provide a comprehensive look at the breadth of sonodelivery techniques for intramuscular gene delivery and suggest future directions for this continuously evolving field.

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“…One way of overcoming this issue is to add polymers to the phospholipid‐bases MBs (Delalande, Postema, Mignet, Midoux, & Pichon, ; Sirsi & Borden, ). Until now, several investigations have been reported to understand the influence of polymers on the structure and stability of MBs (Upadhyay & Dalvi, ). For instance, Lindner et al demonstrated that the properties of the shell of the polymer‐albumin MBs can be easily changed by varying the composition of polymers.…”

Section: Development Of Ultrasound‐responsive Microbubbles: Physiochementioning

confidence: 99%

Enhancing cancer therapeutic efficacy through ultrasound‐mediated micro‐to‐nano conversion

Hameed

Zhang

Bhattarai

et al. 2019

WIREs Nanomed Nanobiotechnol

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Over the last century, significant progress has been made towards the development of microbubbles (MBs) as a contrast agent for imaging and as a carrier for the delivery of therapeutic moieties. The unparalleled ability of MBs to respond to ultrasound (US) render them advantageous for molecular imaging, and US‐responsive targeted delivery. However, the use of MBs has broadened far beyond the imaging contrast agent or drug delivery system alone. Notably, there has been an enormous surge in the design and fabrication of multimodal MBs for cancer therapy. Furthermore, MBs in the presence of the US has unique ability to convert itself from the micro to nanoscale, which offers diagnostic and therapeutic ability in both dimensions. In this review, we summarize the design considerations of MBs, with particular emphasize on their size and composition. In addition, different MBs formulations are discussed in the context of their current progress as an imaging contrast agent and a vehicle for drug/gene delivery. We further highlight recent advancements in the micro‐to‐nano conversion of MBs and their potential application for cancer theranostics. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Microbubble Formulations: Synthesis, Stability, Modeling and Biomedical Applications

Cited by 92 publications

References 272 publications

Intraoperative visualisation and treatment of salivary glands in Sjögren’s syndrome by contrast-enhanced ultrasound sialendoscopy (CEUSS): protocol for a phase I single-centre, single-arm, exploratory study

Intraoperative visualisation and treatment of salivary glands in Sjögren’s syndrome by contrast-enhanced ultrasound sialendoscopy (CEUSS): protocol for a phase I single-centre, single-arm, exploratory study

Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential

Enhancing cancer therapeutic efficacy through ultrasound‐mediated micro‐to‐nano conversion

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