Microcavitation dynamics in viscoelastic tissue during histotripsy process

Abstract

Monitoring bubble cavitations and bubble dynamics are essential in enhancing non-invasive ultrasonic ablation methods like histotripsy that mechanically fractionates tissue into acellular debris using microcavitation. Histotripsy can totally fractionate tissue into a liquid-appearing homogenate with no cellular features with enough pulses. In this paper, we present the analysis of the dynamics of cavitation bubbles in a viscoelastic medium subjected to a histotripsy pulse using different fidelities in depicting compressibility and thermal effects. The mathematical formulation is described based on the Keller-Miksis equation in two models for cavitation bubbles in viscoelastic tissue through histotripsy process; the first model is the Neo-Hookean, and the second is the quadratic Law Kelvin-Voigt (QLKV) model. The governing model is solved analytically based on the modified Plesset-Zwick method. Analysis of the results reveals that the parameters of Young modulus, viscosity effects and stiffening parameter reduce the growth of cavitation microbubbles through the histotripsy process. The cavitation bubble growth increases when the gel concentration decreases since the medium stiffening parameters are experimentally proportional to the gel concentration.

Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review

“…The only weak point that ultrasonic pulse testing technology depicts is the requirement of regular surfaces to enable the accurate measurement of the pulse velocities. Dynamic elastic modulus has been assessed by ultrasonic pulse testing for thermoplastic polymers [ 100 ], photo-clickable poly(ethylene glycol) hydrogels [ 101 ], composite blends [ 102 ], syntactic foams reinforced with hybrid fibers [ 103 ], liquid crystals [ 104 ], biological tissues [ 105 ] such as cortical bone [ 106 ] or pulmonary capillary tissues [ 107 ].…”

Charged Cavitation Multibubbles Dynamics Model: Growth Process

“…Different dynamic pressure imbalances give rise to bubbles of different cavitations, which exhibit numerous volumetric oscillations that have a wide range of use in many important applications. Certain acoustic and induced-laser cavitation bubbles [4][5][6], for instance, are used for medication and gene delivery [7,8], therapeutic biological systems [9][10][11][12], ultrasonic cleaning [13], sonoluminescence [14], inkjet printing [15], and bubble propulsion [16]. The efforts of researchers [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] help the researchers to understand and develop the bubble dynamics and its application, so these results enhance the scientific fields.…”