2020
DOI: 10.1021/acsabm.9b01150
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Microchannel Molding Combined with Layer-by-Layer Approach for the Formation of Three-Dimensional Tube-like Structures by Endothelial Cells

Abstract: The development of a functional in vitro model for microcirculation is an unresolved challenge, with major impact for the creation and regeneration of organs in the tissue engineering. The absence of prevascularized engineered tissues limits enormously their efficacy and integration. Therefore, in this study, the in vitro formation of tubular-like structures with human umbilical vein endothelial cells (HUVECs) is investigated thanks to three-dimensional polycarbonate (PC) microchannel (μCh) scaffolds, surface … Show more

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Cited by 4 publications
(4 citation statements)
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“…S1 †). 119 The carboxyl groups were quantified in triplicate for each surface modification condition. Furthermore, the sample's surface carboxyl group concentration ( pmol mm −2 ) was calculated according to the surface area.…”
Section: Toluidine Blue Assaymentioning
confidence: 99%
“…S1 †). 119 The carboxyl groups were quantified in triplicate for each surface modification condition. Furthermore, the sample's surface carboxyl group concentration ( pmol mm −2 ) was calculated according to the surface area.…”
Section: Toluidine Blue Assaymentioning
confidence: 99%
“…3D scaffolds with microchannels in the order of tens of micrometers were first functionalized with hyaluronic acid/chitosan LbL films grafted with RGD, then human umbilical vein endothelial cells (HUVECs) were seeded on the coatings, mimicking a vascular capillary structure. 157 The outside of the channels can be modified with a specifically designed microfluidic device. As shown in Fig.…”
Section: Microfluidic Systemsmentioning
confidence: 99%
“…These flexile sensing apparatuses, unlike stiff electronics, have a wide span of mechanical characteristics, making manufacturing more difficult. So far, the most common method for making soft sensing apparatuses has been to use transfer printing [3], screen printing [4], photolithography [5], microchannel molding [6], and lamination [7] to combine deformable conducting material patterns onto a stretchy substrate. These technologies, however, have some drawbacks, including high cost, multistep manufacturing processes, low durability, and prototyping and scaling issues.…”
Section: Introductionmentioning
confidence: 99%