2020
DOI: 10.21203/rs.3.rs-109926/v1
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Microchannelled chitosan sponge grafting with hydrophobic alkyl chain for enhanced noncompressible hemorrhage and tissue regeneration

Abstract: Developing an anti-infective shape-memory hemostatic sponge with ability of guiding in situ tissue regeneration for noncompressible hemorrhage in civilian and battlefield settings remains a challenge. Here, hemostatic chitosan sponge with highly interconnective microchannels was engineered by combining 3D printed fiber leaching and freeze-drying methods and then modified with hydrophobic alkyl chains. The microchannelled alkylated chitosan sponge (MACS) exhibited a strong capacity for water/blood absorption an… Show more

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