Microchimerism in women with recurrent miscarriage

Gammill, Hilary S.; Stephenson, Mary D.; Aydelotte, Tessa M.; Nelson, J. Lee

doi:10.1080/19381956.2015.1017241

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Herein, this reasoning was applied to investigate the ontological conservation of NIMA-specific tolerance and maternal cell microchimerism across placental mammalian species (Andrassy et al, 2003; Bakkour et al, 2014; Dutta and Burlingham, 2011; Gammill et al, 2015). Using mice with defined MHC haplotype alleles in multi-generational breeding that transforms MHC haplotype alleles into surrogate NIMA, we show sharply increased resiliency against fetal wastage in the presence of overlap between NIMA and paternal-fetal antigen encountered during next generation pregnancies.…”

Section: Discussionmentioning

confidence: 99%

Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells

Kinder

Jiang

Ertelt

et al. 2015

Cell

113

139

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SUMMARY Exposure to maternal tissue during in utero development imprints tolerance to immunologically foreign non-inherited maternal antigens (NIMA) that persists into adulthood. The biological advantage of this tolerance, conserved across mammalian species, remains unclear. Here we show that maternal cells which establish microchimerism in female offspring during development promote systemic accumulation of immune suppressive regulatory T cells (Tregs) with NIMA specificity. NIMA-specific Tregs expand during pregnancies sired by males expressing alloantigens with overlapping NIMA specificity, thereby averting fetal wastage triggered by prenatal infection and non-infectious disruptions of fetal tolerance. Therefore, exposure to NIMA selectively enhances reproductive success in second-generation females carrying embryos with overlapping paternally inherited antigens. These findings demonstrate that genetic fitness, canonically thought to be restricted to Mendelian inheritance, is enhanced in female placental mammals through vertically transferred maternal cells that promote conservation of NIMA and enforce cross-generational reproductive benefits.

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Section: Discussionmentioning

confidence: 99%

Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells

Kinder

Jiang

Ertelt

et al. 2015

Cell

113

139

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“…Foetuses with genetic anomalies are also more likely to be spontaneously or medically aborted. Pregnancies with poor outcomes have been associated with increased risk of poor outcomes in subsequent pregnancies [ 36 ]. This may explain the association between spontaneous and induced abortions with risk of RA and the dose-response relationship of the number of pregnancy losses.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy loss and the risk of rheumatoid arthritis in Chinese women: findings from the China Kadoorie biobank

Hee

Pang

et al. 2022

BMC Public Health

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Considering the female preponderance of rheumatoid arthritis (RA), and disease onset typically after the reproductive years, pregnancy and childbirth may play a role in the aetiology of the disease. Adverse outcomes of pregnancy have been found to precede the diagnosis of autoimmune diseases, including RA, but the evidence is scant and inconsistent. Therefore, we investigate whether pregnancy loss is associated with the risk of RA in Chinese women. Data from the China Kadoorie Biobank, conducted by the University of Oxford and the Chinese Centre for Disease Control and Prevention, of 299,629 Chinese women who had been pregnant were used. Multivariable logistic regression and stratified analyses were employed to analyse the association between types of pregnancy loss with the risk of RA. Pregnancy loss was significantly associated with increased risk of RA (OR 1.12, 95% CI 1.06–1.18), specifically, spontaneous (OR 1.11, 95% CI 1.03–1.20) and induced abortions (OR 1.11, 95% CI 1.06–1.17). There was no significant association between stillbirth and the risk of RA (OR 1.07, 95% CI 0.97–1.18). The risk of developing RA increases with the number of pregnancy losses: one loss confers an OR of 1.09 (95% CI 1.03–1.16), two an OR of 1.13 (95% CI 1.05–1.20), three or more an OR of 1.19 (95% CI 1.10–1.28) and OR of 1.06 (95% CI 1.03–1.08) for each additional. Spontaneous and induced abortions are associated with an increased risk of RA in Chinese women.

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“…A woman has a higher risk of miscarriage if she is over age 35 years, has certain diseases, such as diabetes or thyroid problems or had three or more miscarriages. Abortion may be due to weakness of the cervix, incompetent cervix, which cannot hold the pregnancy usually in the second trimester [1,12].…”

Section: Discussionmentioning

confidence: 99%

Rate of Different Types of Abortion in Madinah Maternity and Children Hospital, Madinah, Saudi Arabia

Othman

2018

IGRWH

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Abortion is the loss of the fetus before it is viable. It is one of the commonest complications of pregnancy, occurring in 12%-26% of pregnancies. Causes of abortion include chromosomal problems, infection, maternal chronic diseases, (for example diabetes), hormone problems, immune system responses, body mass index (BMI) issues of the mother, and uterine abnormalities. Abortion can be diagnosed and confirmed by pelvic examination and ultrasound. It is six types, and this is a retrospective study, which was carried out in Madinah Maternity and Children Hospital (MMCH), Madinah, Saudi Arabia, to find out the rate of different types of abortion in Madinah Maternity and Children Hospital (MMCH) in the year 2016. Results showed that abortion represents 95% of early bleeding patients of MMCH. The commonest type of abortion in MMCH was incomplete abortion. The reason most probably is the advanced age and grand multiparity, with the other mentioned above causes. More detailed will organized prospective trials are needed to confirm the main causes.

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Microchimerism in women with recurrent miscarriage

Cited by 7 publications

References 26 publications

Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells

Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells

Pregnancy loss and the risk of rheumatoid arthritis in Chinese women: findings from the China Kadoorie biobank

Rate of Different Types of Abortion in Madinah Maternity and Children Hospital, Madinah, Saudi Arabia

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