Microchips as Controlled Drug-Delivery Devices

Santini, John T.; Richards, Amy C.; Scheidt, Rebecca A.; Cima, Michael J.; Langer, Robert

doi:10.1002/1521-3773(20000717)39:14<2396::aid-anie2396>3.3.co;2-l

Cited by 78 publications

(116 citation statements)

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“…There have been limited attempts to date using microelectronics and membrane reservoirs for remote-controlled drug delivery 223–225 . Those devices could be integrated with hydrogel drug delivery systems to create next-generation bioelectronics with therapeutic function.…”

Section: Discussionmentioning

confidence: 99%

Designing hydrogels for controlled drug delivery

2016

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Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel–drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.

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Section: Discussionmentioning

confidence: 99%

Designing hydrogels for controlled drug delivery

2016

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“…[95] To our knowledge infusion pumps in the market that have been referred to as Chronomodulating for drug delivery application include, Melodie ® , [96] programmable Synchromed ® , [97] Panomat ® V5 infusion, [98] and the Rhythmic ® [99] pumps. The portable pumps are usually characterized by a light weight (300 -500 g) for easy portability and precision in drug delivery.…”

Section: Chronomodulating Infusion Pumpsmentioning

confidence: 99%

Chronomodulated drug delivery system: A comprehensive review on the recent advances in a new sub-discipline of ′chronopharmaceutics′

Bisht¹

2011

Asian J Pharm

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W ith the advancement in the field of chronobiology, modern drug delivery approaches have been elevated to a new concept of chronopharmacology, that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. The mammalian circadian pacemaker resides in the paired suprachiasmatic nuclei and influences a multitude of biological processes, including the sleep-wake rhythm. Clock genes are the genes that control the circadian rhythms in physiology and behavior. Twenty-four hours rhythms are demonstrated for the function of physiology and the pathophysiology of diseases. The effectiveness and toxicity of many drugs vary depending on the dosing time. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics, but also the pharmacokinetics of medications. The underlying mechanisms are associated with the 24-hour rhythms of biochemical, physiological, and behavioral processes under the control of the circadian clock. New technology for delivering medications precisely in a time-modulated fashion, by bedside or ambulatory pumps, is being developed to manage human diseases. From the point of view of pharmaceutics, the application of a biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tablets and capsules, and a special drug delivery system, to synchronize the drug concentrations with the rhythms in the disease activity. Therefore, the present article gives an overview of the dosing time-dependent alterations in the therapeutic outcome and safety of the drug. The underlying mechanisms and usefulness are introduced from the point of view of chronopharmacology and chronotherapy.

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“…The route of drug delivery has a significant effect on the drug’s therapeutic efficacy, safety, and bioavailability [14]. The ideal aim of administration should be to deliver the drug at a required concentration within the therapeutic window at the right time to a specific target, in a safe and reproducible manner.…”

Section: Introductionmentioning

confidence: 99%

Emerging microtechnologies for the development of oral drug delivery devices

Chirra

Desai

2012

Advanced Drug Delivery Reviews

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The development of oral drug delivery platforms for administering therapeutics in a safe and effective manner across the gastrointestinal epithelium is of much importance. A variety of delivery systems such as enterically coated tablets, capsules, particles, and liposomes have been developed to improve oral bioavailability of drugs. However, orally administered drugs suffer from poor localization and therapeutic efficacy due to various physiological conditions such as low pH, and high shear intestinal fluid flow. Novel platforms combining controlled release, improved adhesion, tissue penetration, and selective intestinal targeting may overcome these issues and potentially diminish the toxicity and high frequency of administration associated with conventional oral delivery. Microfabrication along with appropriate surface chemistry, provide a means to fabricate these platforms en masse with flexibility in tailoring the shape, size, reservoir volume, and surface characteristics of microdevices. Moreover, the same technology can be used to include integrated circuit technology and sensors for designing sophisticated autonomous drug delivery devices that promise to significantly improve point of care diagnostic and therapeutic medical applications. This review sheds light on some of the fabrication techniques and addresses a few of the microfabricated devices that can be effectively used for controlled oral drug delivery applications.

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Microchips as Controlled Drug-Delivery Devices

Cited by 78 publications

References 0 publications

Designing hydrogels for controlled drug delivery

Designing hydrogels for controlled drug delivery

Chronomodulated drug delivery system: A comprehensive review on the recent advances in a new sub-discipline of ′chronopharmaceutics′

Emerging microtechnologies for the development of oral drug delivery devices

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