Microchips, microarrays, biochips and nanochips: personal laboratories for the 21st century

Kricka, Larry J.

doi:10.1016/s0009-8981(01)00451-x

Cited by 174 publications

(84 citation statements)

References 69 publications

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“…1 Characteristics such as strength, transparency, and deformability, allied to simple manufacturing techniques, make polymers desirable for the production of goods ranging from automobile bumpers to drink bottles. In academia, and especially in the biological sciences, development of polymer-based apparatus, such as lab-on-a-chip devices 2 or biochips, 3 continues apace. The same characteristics, advantageous for the production of consumable goods, make polymeric materials useful for producing biological apparatus.…”

Section: Introductionmentioning

confidence: 99%

Transparent micro‐ and nanopatterned poly(lactic acid) for biomedical applications

Mills

Navarro

Engel

et al. 2005

J Biomedical Materials Res

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Abstract:The formation of structures in poly(lactic acid) has been investigated with respect to producing areas of regular, superficial features with dimensions comparable to those of cells or biological macromolecules. Nanoembossing, a novel method of pattern replication in polymers, has been used for the production of features ranging from tens of micrometers, covering areas up to 1 cm 2 , down to hundreds of nanometers. Both micro-and nanostructures are faithfully replicated. Contact-angle measurements suggest that positive microstructuring of the polymer (where features protrude from the polymer surface) produces a more hydrophilic surface than negative microstructuring. The ability to structure the surface of the poly(lactic acid), allied to the polymer's postprocessing transparency and proven biocompatibility, means that thin films produced in this way will be useful for bioengineers studying the interaction of microand nanodimensioned features with biological specimen, with regard to tissue engineering, for example.

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Section: Introductionmentioning

confidence: 99%

Transparent micro‐ and nanopatterned poly(lactic acid) for biomedical applications

Mills

Navarro

Engel

et al. 2005

J Biomedical Materials Res

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“…Microchips with inclusive capabilities can translate complicated, multistep analytical laboratory assays into fully automated handheld devices available in non-laboratory settings. The pursuit of these futuristic, fully integrated analytical devices has spawned the development of microscale technologies to (i) isolate and immobilize specific cells of interest, (ii) distinguish͞separate cells or subcellular organelles, (iii) amplify signals that fall below the sensitivity thresholds, and (iv) communicate quantitative results as outputs (27,28). A variety of electrical, optical, and biochemical approaches have been explored for each of these stages.…”

Section: Enabling Chip Technologiesmentioning

confidence: 99%

Designing a nano-interface in a microfluidic chip to probe living cells: Challenges and perspectives

Helmke

Minerick

2006

Proc. Natl. Acad. Sci. U.S.A.

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Nanotechnology-based materials are beginning to emerge as promising platforms for biomedical analysis, but measurement and control at the cell-chip interface remain challenging. This idea served as the basis for discussion in a focus group at the recent National Academies Keck Futures Initiative. In this Perspective, we first outline recent advances and limitations in measuring nanoscale mechanical, biochemical, and electrical interactions at the interface between biomaterials and living cells. Second, we present emerging experimental and conceptual platforms for probing living cells with nanotechnology-based tools in a microfluidic chip. Finally, we explore future directions and critical needs for engineering the cell-chip interface to create an integrated system capable of highresolution analysis and control of cellular physiology.

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“…The trend of miniaturization has been discussed in several publications (Kricka 2001;Khandurina and Guttman 2002;Cleary et al 2005). In clinical practices, it is often faced with the problem of a very small volume of samples.…”

Section: Introductionmentioning

confidence: 99%

“…However, they require access to advanced clean room facilities and time-consuming processes similar to those used for microelectronics, which hamper the rapid turnaround of new design. Today, silicon and glass materials have largely been replaced by polymer-based materials, such as polydimethylsiloxene (PDMS), polymethylmethacrylate (PMMA), and polycarbonate (Grodzinski et al 2001;Kameoka et al 2001;Kricka 2001;Chovan and Guttman 2002). PDMS appeared as a good choice mainly due to its ease of handling, low-cost, and optical transparency (Grodzinski et al 2001;Kameoka et al 2001;Linder et al 2001;Chovan and Guttman 2002).…”

Section: Introductionmentioning

confidence: 99%

Modeling Fluorescence Detection for Microfluidic Card

Irawan

Tjin

Zhang

et al. 2007

International Journal of Optomechatronics

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Simple fluorescence detection system and disposable microfluidic card have been developed and tested. A blue LED, optical fiber, CCD detector, Mylar and PMMA, and fluorescein and BSA-FITC were used as an excitation source, waveguide, detector, microfluidic substrate, and sample, respectively. The results show the system can detect 0.01-1000 ng/ml of fluorescein solutions with linear response. A technique to avoid cross-talks between the adjacent channels in a multi-channel microfluidic card is also addressed. The test using BSA as a model analyte demonstrates its feasibility for on-chip biosensor applications. This prototype can be used as a platform to develop a compact bio-fluorescence sensor for microfluidic analysis systems.

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Microchips, microarrays, biochips and nanochips: personal laboratories for the 21st century

Cited by 174 publications

References 69 publications

Transparent micro‐ and nanopatterned poly(lactic acid) for biomedical applications

Transparent micro‐ and nanopatterned poly(lactic acid) for biomedical applications

Designing a nano-interface in a microfluidic chip to probe living cells: Challenges and perspectives

Modeling Fluorescence Detection for Microfluidic Card

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