Microcirculation and Vasomotor Function of the Endothelium in Elderly People With Impaired Glucose Tolerance

Abstract

The peculiarities of microcirculation and vasomotor function of the endothelium and their relationship with resistance to hypoxia in the elderly with impaired glucose tolerance were studied. It has been shown that in the elderly with impaired glucose tolerance, skin microcirculation and vasomotor function of the endothelium are reduced when breathing air. An inverse correlation has been established between disorders of carbohydrate metabolism, the state of skin microcirculation and vasomotor function of the endothelium. The connection between the shift of blood saturation under hypoxic load and indicators of microcirculation and vasomotor function of the endothelium in the elderly with both impaired and preserved glucose tolerance. But in the elderly with impaired glucose tolerance, the strength of these connections is greater.

Changes of endothelial function and oxidant status in insulin resistance and obesity under the conditions of iodine deficiency

“…Such mechanisms are accompanied by the development of oxidative stress, because the early trigger of endothelial dysfunction is an imbalance between the accumulation of the active oxygen forms and the bioavailability of NO. It is known that if the iNOS gene of diabetic rats is transferred into intact arteries, then NO-dependent vasodilation is damaged, which characterizes the development of endothelial dysfunction [22]. It is likely that the NO-synthase pathway of L-arginine metabolism is activated in experimental animals, which leads to an increase in the activity of iNOS in diabetes mellitus, which, under conditions of oxidative stress, can turn into compounds toxic to the body, in particular, peroxynitrite, dinitrogen trioxide, nitrates and nitrites [23].…”