Microcirculatory disorders in ischemic/reperfusion hepatic injury

Abstract

Klinički centar, *Hirurška klinika, † Klinika za endokrinologiju, dijabetes i bolesti metabolizma, ‡ Klinika za plastičnu i rekonstruktivnu hirurgiju, Niš Ključne reči: jetra; mikrocirkulacija; ishemija; povreda, reperfuziona; endotel; patologija.

Anaphylaxis on graft reperfusion during orthotopic liver transplantation: A case study

“…The differential diagnosis included the following: myocardial dysfunctions (intracardiac thrombosis, infarctions, heart failure, etc. ), pulmonary embolism, anaphylaxis, electrolyte imbalance, acute graft rejection [2][3][4][5][6][7][8]. Extended invasive hemodynamic monitoring could have solved some of the differential diagnostic dilemmas.…”

“…The patient was also exhibiting signs of portal hypertension and grade II/III esophageal varices. The model for end-stage liver disease (MELD) score was 13 and the Child-Pugh score was A (5). He had no previous history of allergic reactions.…”

“…Such changes are caused by irrigating harmful products, accumulated during ischemia, from graft into the blood flow. These products include cold UW solution, acids as products of anaerobic metabolism, proinflammatory cytokines (IL-6, TNFα), as well as cellular products responsible for systemic inflammatory reactions [2][3][4][5]. The PRS incidence shows wide variations ranging from 5.9% to 61.3% [1].…”

“…The PRS incidence shows wide variations ranging from 5.9% to 61.3% [1]. Such wide variation is due to different surgical approaches and techniques, different intraoperative hemodynamic treatments, duration of different phases during surgery, duration of cold and warm ischemia, as well as demographic factors regarding donor and recipient [1,2,5,6,7].…”