Microcomposites theophylline/hydrogenated palm oil from a PGSS process for controlled drug delivery systems

Rodrigues, Miguel A.; Peiriço, N; Matos, Henrique A.; Azevedo, Edmundo Gomes de; Lobato, M.R; Almeida, António J.

doi:10.1016/s0896-8446(03)00034-2

Cited by 106 publications

(53 citation statements)

References 12 publications

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“…Another important trend in precipitation research that has been highlighted in this chapter is the emphasis on understanding the fundamental mechanisms that drive these precipitation processes, in order to facilitate successful scale-up of the precipitation techniques and promote their utility in commercial settings. Increased knowledge of these precipitation technologies benefi ts not only the microparticle/nanoparticle production fi elds but also areas of drug encapsulation (Rodrigues et al 2004 ;Li et al 2005 ;Young et al 1999 ) and cocrystallization ) and will be of general interest for all sectors involving particle engineering. Novel particle recovery processes, based on controlled fl occulation/fi ltration of primary nanoparticles, have also been discussed as an effi cient means to harvest nanoparticles after precipitation, making precipitation processes more attractive and feasible for industrial production.…”

Section: Discussionmentioning

confidence: 99%

“…Benefi ts of this process are that it consumes less CO 2 than the previously discussed SCF technologies, may be operated under moderate pressures (10-15 MPa), and solubility of the drug in the CO 2 is not necessary to achieve high process yields, as the drug can be dispersed in the melted solid (Martin et al 2010 ;Perrut et al 2005 ) . Therefore, this precipitation process is optimal for polymer encapsulation and is capable of particle micronization, typically yielding micron-sized particles, larger than achieved by RESS (~3-60 m m for theophylline and PEG 6000 (Martin et al 2010 ;Rodrigues et al 2004 ) . Theoretical models that describe the PGSS process, which were built upon existing RESS models, suggest that the larger particles produced by PGSS compared to RESS are due to signifi cant coagulation in the free jet region (Martin and Cocero 2008 ;Li et al 2005 ) .…”

Section: Particles From Gas Saturated Solutions (Pgss) Processmentioning

confidence: 99%

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Precipitation Technologies for Nanoparticle Production

Rowe¹,

Johnston²

2011

Formulating Poorly Water Soluble Drugs

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Precipitation technologies have been widely studied for nanoparticle production because they provide more control over particle size, shape, and morphology as compared to mechanical processes, such as milling and homogenization. Several precipitation processes are discussed in this chapter, with special attention to experimental parameters and typical particle attributes. The chapter also touches on novel nanoparticle recovery techniques that may be coupled with precipitation processes to enable these precipitation technologies to be scaled for commercial applications.

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Section: Discussionmentioning

confidence: 99%

Section: Particles From Gas Saturated Solutions (Pgss) Processmentioning

confidence: 99%

Precipitation Technologies for Nanoparticle Production

Rowe¹,

Johnston²

2011

Formulating Poorly Water Soluble Drugs

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“…Rodrigues et al [129] obtained theophylline/HPO microcomposites by PGSS, the results showed that P had no significant effect on PS. However, particles shaped like needles, threads or fibers were more abundant at low pre-expansion P.…”

Section: Tailoring Particle Microstructures Via Scf Co-precipitation/mentioning

confidence: 99%

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

Liu¹,

Jiang

Wang³

2015

CPD

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Strategies for a particular drug delivery are always of great interest for the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures.Combining with research experiences in our research group, this review aims to provide a theoretical framework of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties are directly influenced by the particle microstructures, "Inverse" strategies are introduced at first to obtain the needed particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focus on the screening and selection of operating parameters according to thermodynamics and fluid dynamics study. Recent examples of SCF micronization and co-precipitation/ encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters.Finally, challenges and issues needed further study are briefly suggested for SCD PD.

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“…Currently, various studies have focused on the composite particles prepared by using this technique. For example, Rodrigues et al [7] prepared microcomposites theophylline/hydrogenated palm oil from a conventional PGSS process and found that limited theophylline was encapsulated in hydrogenated palm oil. Wang et al [8] investigated lipid/ibuprofen system and controlled release is obviously achieved by the process.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Menthol in Beeswax by a Supercritical Fluid Technique

Zhu

Lan

et al. 2010

International Journal of Chemical Engineering

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Encapsulation of menthol in beeswax was prepared by a modified particles from gas-saturated solutions (PGSS) process with controlling the gas-saturated solution flow rate. Menthol/beeswax particles with size in the range of 2-50 μm were produced. The effects of the process conditions, namely, the pre-expansion pressure, pre-expansion temperature, gas-saturated solution flow rate, and menthol composition, on the particle size, particle size distribution, and menthol encapsulation rate were investigated. Results indicated that in the range of studied conditions, increase of the pressure, decrease of the gas-saturated solution flow rate, and decrease of the menthol mass fraction can decrease the particle size and narrow particle size distribution of the produced menthol/beeswax microparticles. An N 2 -blowing method was proposed to measure the menthol release from the menthol/beeswax microparticles. Results showed that the microparticles have obvious protection of menthol from its volatilization loss.

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Microcomposites theophylline/hydrogenated palm oil from a PGSS process for controlled drug delivery systems

Cited by 106 publications

References 12 publications

Precipitation Technologies for Nanoparticle Production

Precipitation Technologies for Nanoparticle Production

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

Encapsulation of Menthol in Beeswax by a Supercritical Fluid Technique

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