Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll compaction

Pishnamazi, Mahboubeh; Casilagan, Stephanie; Clancy, Cian; Shirazian, Saeed; Iqbal, Javed; Egan, David; Edlin, Chris D.; Croker, Denise M.; Walker, Gavin; Collins, Maurice N.

doi:10.1016/j.powtec.2018.07.003

Cited by 78 publications

(25 citation statements)

References 36 publications

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“…Considering environmental benefits, lignocellulosic materials being green, sustainable, and biodegradable [ 75 , 76 ]. This renewable material also facilitates its applicability as an environmentally friendly wet wipe substrate for achieving the large-scale commercial production, increasingly investigated both in research and industry [ [77] , [78] , [79] ]. Besides, the ubiquity of microplastic fibers degraded from widely flushed personal care textile products (wet wipes and sanitary towels) were comprised of PP and polystyrene [ 73 ], which confirms that wet wipes (non-cellulose substrate) and sanitary towels flushed down to toilets are an underestimated source of white microplastic fibers in the environment.…”

Section: Resultsmentioning

confidence: 99%

Balancing the decomposable behavior and wet tensile mechanical property of cellulose-based wet wipe substrates by the aqueous adhesive

Yun

Cheng

Qian

et al. 2020

International Journal of Biological Macromolecules

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With the current global outbreak of novel coronaviruses, the fabrication of decomposable wet wipe with sufficient wet strength to meet daily use is promising but still challenging, especially when renewable cellulose was employed. In this work, a decomposable cellulose-based wet wipe substrate is demonstrated by introducing a synthetic N-vinyl pyrrolidone-glycidyl methacrylate (NVP-GMA) adhesive on the cellulose surface. Experimental results reveal that the NVP-GMA adhesive not only significantly facilitates the chemical bonding between cellulose fibers in the wet state, but also increase the surface wettability and water retention. The as-fabricated cellulose-based wet wipe substrate displays a superb water retention capacity of 1.9 times, an excellent water absorption capacity (completely wetted with 0° water contact angle), and a perfect wet tensile index of 3.32 N.m.g −1 . It is far better than state-of-the-art wet toilet wipe on the market (non-woven). The prepared renewable and degradable cellulose-based substrate with excellent mechanical strength has potential application prospects in diverse commercially available products such as sanitary and medical wet wipes.

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Section: Resultsmentioning

confidence: 99%

Balancing the decomposable behavior and wet tensile mechanical property of cellulose-based wet wipe substrates by the aqueous adhesive

Yun

Cheng

Qian

et al. 2020

International Journal of Biological Macromolecules

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“…In the literature [34,35,[51][52][53][54], it was demonstrated that the roll pressure was the most important process parameter that affected the resulting ribbons. In this paper, only the hydraulic pressure was considered as the critical process parameter (CPP) in order to fully understand the impacts of raw material properties on ribbon qualities.…”

Section: Roll Compaction and Ribbon Productionmentioning

confidence: 99%

Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction

Zhang

et al. 2019

Pharmaceutics

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The purpose of this study is to use a material library to investigate the effect of raw material properties on ribbon tensile strength (TS) and solid fraction (SF) in the roll compaction (RC) process. A total of 81 pharmaceutical materials, including 53 excipients and 28 natural product powders (NPPs), were characterized by 22 material descriptors and were compacted under five different hydraulic pressures. The transversal and longitudinal splitting behaviors of the ribbons were summarized. The TS-porosity and TS-pressure relationships were used to explain the roll compaction behavior of powdered materials. Through defining the target ribbon quality (i.e., 0.6 ≤ SF ≤ 0.8 and TS ≥ 1 MPa), the roll compaction behavior classification system (RCBCS) was built and 81 materials were classified into three categories. A total of 24 excipients and five NPPs were classified as Category I materials, which fulfilled the target ribbon quality and had less occurrence of transversal splitting. Moreover, the multivariate relationships between raw material descriptors, the hydraulic pressure and ribbon quality attributes were obtained by PLS regression. Four density-related material descriptors and the cohesion index were identified as critical material attributes (CMAs). The multi-objective design space summarizing the feasible material properties and operational region for the RC process were visualized. The RCBCS presented in this paper enables a formulator to perform the initial risk assessment of any new materials, and the data modeling method helps to predict the impact of formulation ingredients on strength and porosity of compacts.

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“…Lignin is the secondmost abundant biopolymer and is a by-product of the paper and pulp industry. These factors ensure lignin's low cost, minimised greenhouse gas emissions, and suitability for energy applications [32,33]. Lignin is considered a promising bio-based carbon fibre precursor as its aromatic structure promotes graphitisation during carbonisation [29,[34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Thermoelectric properties of electrospun carbon nanofibres derived from lignin

Dalton

Lynch

Collins

et al. 2019

International Journal of Biological Macromolecules

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107

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Developing sustainable and efficient thermoelectric materials is a challenge because the most common thermoelectric materials are based on rare elements such as bismuth and telluride. In this context, we have produced bio-based carbon nanofibres (CNFs) derived from mixtures of polyacrylonitrile and lignin using electrospinning. The addition of lignin (up to 70%) reduces the diameter of CNFs from 450 nm to 250 nm, increases sample flexibility, and promotes inter-fibre fusion. The crystalline structure of the CNFs was analysed by Raman spectroscopy. The electrical conductivity and the Seebeck coefficient were evaluated as function of the lignin content in the precursor and carbonised equivalents. Finally, a conversion of p-type to n-type semiconducting behaviour was achieved with a hydrazine vapour treatment. We observe a maximum p-type power factor of 9.27 μW cm-1 K-2 for CNFs carbonised at 900°C with 70% lignin which is a 34.5-fold increase to the CNFs with 0% lignin. For the hydrazine treated samples, we observe a maximum n-type power factor of 10.2 μW cm-1 K-2 for the CNFs produced in the same way which is an 11.0-fold increase to the hydrazine-treated CNFs with 0% lignin.

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Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll compaction

Cited by 78 publications

References 36 publications

Balancing the decomposable behavior and wet tensile mechanical property of cellulose-based wet wipe substrates by the aqueous adhesive

Balancing the decomposable behavior and wet tensile mechanical property of cellulose-based wet wipe substrates by the aqueous adhesive

Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction

Thermoelectric properties of electrospun carbon nanofibres derived from lignin

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