Microcylinders of endoplasmic reticulum in histiocytes in patients suffering from Degos' syndrome and dermatomyositis

Olmos, L.; Hunziker, N; Laugier, P

doi:10.1111/j.1365-2133.1979.tb05551.x

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…On the other hand, the lamellar structures not infrequently observed in case 3 have close similarities to the structures already described in other human diseases (13). Olmos et al (13) reported intraendoplasmic lamellar structures which they called microcylinders in the infiltrating histiocytes in one case each of Degos' malignant atrophic papulosis and dermatomyositis. These structures were composed of a double smooth membrane unit.…”

Section: Discussionsupporting

confidence: 75%

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Ultrastructure of Senile Keratosis

Kimura

1980

The Journal of Dermatology

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Three cases of a hypertrophic type of senile keratosis were examined by an electron microscope. All three showed similar changes, although some variability from case to case was also observed. Lesional epidermis showed widened intercellular spaces with microvilli‐formation, a general increase in the bulk of the basal cells, a decrease in number of desmosomes, a decrease in the amount of tonofilaments, various degrees of aggregations of tonofibrils, binucleated keratinocytes, mitotic figures, prominent nucleoli, and an increase in number of nuclear bodies. In lesional dermoepidermal junctions, discontinuity of the basal lamina with cytoplasmic projections of the basal cells to the upper dermis was not infrequently observed. These changes are similar to those found in Bowen's disease, but are somewhat milder. In addition, in one case, keratinocytes of lesional epidermis showed lamellar structures closely associated with the rough endoplasmic reticulum. Significance of these structures is discussed.

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Section: Discussionsupporting

confidence: 75%

“…Ultrastructural modification of ER occurs in a variety of pathologic processes (14). Pairing or stacking of ER which may apply to the structures in our case as well as in the cases of Olmos et al (13) has already been described in cultured peripheral blood leukocytes of a patient with. acute lymphocytic leukemia (16).…”

Section: Discussionsupporting

confidence: 59%

Ultrastructure of Senile Keratosis

Kimura

1980

The Journal of Dermatology

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“…Although the etiology of Degos' disease is unknown, a n immunologic mechanism is considered due to the presence of antiphospholipid antibodies and immunoglobulin deposits.2'-24 In some cases, electron microscopy has revealed swollen vascular endothelial cells that contain tubuloreticular structures resembling paramyxovirus particles, but they may be nonspecific and likely a degenerative effect, 25 27 There is no direct evidence to substantiate a viral origin.…”

Section: Discussionmentioning

confidence: 97%

Skin lesion with a fatal neurologic outcome (Degos' disease)

Subbiah¹,

Wijdicks

Muenter

et al. 1996

Neurology

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Degos' disease, a rare multisystem vasculopathy of unknown etiology, only occasionally involves the nervous system. We report the Mayo Clinic experience of the neurologic features of Degos' disease in a series of 15 patients. All 15 patients had the typical skin lesions of Degos' disease, confirmed by skin biopsy. Ten patients developed neurologic manifestations including fatal hemorrhagic or ischemic strokes (n=5), disabling polyradiculoneuropathy (n=1), and nonspecific neurologic symptoms without objective findings (n=4). Results of laboratory tests varied but none were pathognomonic of the disease. Long-term follow-up revealed death in six patients; nine patients were nearly asymptomatic. Immunosuppressive and antiplatelet agents were not of benefit. CNS infarcts and hemorrhages with intravascular thrombi, but without evidence of vasculitis, were characterized features at autopsy.

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“…Besides, we believe that the child with JDM and livedoid vasculitis described by Olmos et al 13 could actually have presented JDM with Degos-like disease, since the microcylinders of endoplasmic reticulum in histiocytes described in their patient were also seen in an adult with the classic features of Degos' disease. In our patient, armpit and upper limb lesions, not typical for JDM, were clinically and histopathologically compatible with Degos-like disease.…”

Section: Discussionmentioning

confidence: 71%

Long-Term Follow-Up of A Patient with Juvenile Dermatomyositis and Degos-Like Disease

Antonio

Espinosa-Navarro

Selma

et al. 2020

Preprint

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Background: Degos-like disease has been associated with several rheumatologic conditions such as systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis and rheumatoid arthritis. Case presentation: Seven-year-old girl with low weight, height and body mass index who presented with swollen eyelids with ptosis, suggestive cutaneous features of juvenile dermatomyositis along with the presence of scarce papules with hematic crusts and white atrophic scars with an erythematous rim (Degos-like), dysphagia, flaccid paralysis and proximal and distal weakness. With the use of several immunosuppressants the disease was controlled; and after 7 years of follow-up the patient’s condition remains stable.Conclusion: Herein we describe a unique case of juvenile dermatomyositis associated with Degos-like disease responsive to treatment and a long follow-up.

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Microcylinders of endoplasmic reticulum in histiocytes in patients suffering from Degos' syndrome and dermatomyositis

Cited by 11 publications

References 13 publications

Ultrastructure of Senile Keratosis

Ultrastructure of Senile Keratosis

Skin lesion with a fatal neurologic outcome (Degos' disease)

Long-Term Follow-Up of A Patient with Juvenile Dermatomyositis and Degos-Like Disease

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