Microcystic Adnexal Carcinoma: Report of Seven Cases Including One with Lung Metastasis

Gabillot-Carré, M.; Weill, F; Mamelle, G.; Kolb, F.; Boitier, F.; Petrow, Peter; Ortoli, J C; Margulis, A; Souteyrand, P; Mercier, Sandrine; Spatz, Alan; Duvillard, P.; Validire, Pierre; Avril, M.-F.

doi:10.1159/000091248

Cited by 56 publications

(67 citation statements)

References 64 publications

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“…There have been only a few cases of metastasis. [82][83][84] The lesion originates in the dermis and is poorly circumscribed. Basaloid keratinocytes and ducts are 2 primary components.…”

Section: Microcystic Adnexal Carcinomamentioning

confidence: 99%

Malignant Skin Neoplasms

Ricotti

Bouzari

Agadi³

et al. 2009

Medical Clinics of North America

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Skin cancer is the most common form of cancer in the United States, with the incidence increasing considerably. At current rates in the United States, a skin cancer will develop in 1 in 6 people during their lifetime.1 The most common of skin cancers may be categorized into 2 major groups: melanoma and nonmelanoma skin cancers. The latter group consists primarily of basal cell carcinomas and squamous cell carcinomas. Roughly 1,200,000 nonmelanoma skin cancers develop annually in the United States. These tumors are rarely fatal, but are considered to be fast growing tumors that if neglected may be locally and functionally destructive.In contrast, melanoma represents 5% of all diagnosed cancers in the United States, 15% of which prove to be fatal.3 Although melanoma is seen more with increasing age, it is the most frequent cancer plaguing women aged 25 to 29 years, and the second most frequent cancer afflicting women aged 30 to 34.2 Tumor depth is the most important prognostic indicator for melanoma, thus early recognition and management are imperative for improved therapeutic outcome.Although the nonmelanoma and melanoma skin cancers encompass the vast majority of skin cancers, there is a large number of other malignancies of the skin that are less commonly confronted by the clinician. Neoplasms of the skin classically have been divided into those that differentiate from the epidermis, dermis, adnexal structures of the skin, and those derived systemically. This review focuses on the most frequent malignant neoplasms, and divides them into those that are classically designated nonmelanoma skin cancers (also known as keratinocytic tumors), melanoma, and other less common skin cancers of the skin. An extensive list of skin malignancies is provided in Box 1.

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“…There have been only a few cases of metastasis. [82][83][84] The lesion originates in the dermis and is poorly circumscribed. Basaloid keratinocytes and ducts are 2 primary components.…”

Section: Microcystic Adnexal Carcinomamentioning

confidence: 99%

Malignant Skin Neoplasms

Ricotti

Bouzari

Agadi³

et al. 2009

Medical Clinics of North America

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“…Regional and distant metastasis have been described in the literature; however, such cases are particularly rare, with only five cases of local recurrence and three cases of distant metastasis reported (25,26). According to the relevant literature, only one mortality has occurred as a result of the disease (27).…”

Section: Discussionmentioning

confidence: 99%

Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature

et al. 2016

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Abstract. Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. The patient underwent complete surgical resection and the tumor was successfully excised. During 6 months of follow-up, there was no evidence of recurrence. To the best of our knowledge, the present case is the first Chinese case to be reported in the English literature, and is presented with the aim of increasing the awareness and aiding in the management of MAC in non-Caucasian populations. IntroductionMicrocystic adnexal carcinoma (MAC) was originally defined in 1982 (1), and is now also termed sclerosing sweat duct carcinoma (2). MAC is a rare, slow-growing, locally aggressive tumor of the eccrine sweat glands, and is characterized by pilar and eccrine differentiation (3). Sweat gland malignancies, combining all types, are particularly rare, accounting for 0.005% of all malignant epithelial neoplasms (4), with a total of ~350 cases currently described in the English literature. It has been reported that the preferential location for the development of this neoplasm is the head and neck region (5).When referring to the English literature, it is evident that MAC primarily affects the Caucasian population, with only two cases occurring in non-Caucasian patients (6,7). Fang et al (8) described two cases involving Chinese individuals in the Chinese literature; however, to the best of our knowledge, there are no cases of Chinese patients with MAC currently reported in the English literature. The present study reviewed all patients that were referred to the Hainan Province People's Hospital (Haikou, China) between January 1994 and January 2014, and identified only one patient with a MAC diagnosis. This case is described herein along with a review of the relevant literature. Case reportA 38-year-old woman was referred to the Department of Oral and Maxillofacial Surgery at the Hainan Province People's Hospital with a mass on the left upper-lip that had been present for >10 years (Fig. 1). During physical examination, it was noted that the tumor was positioned in the left-upper lip and subnasal region. The lesion was a firm, solitary mass, and measured 2x1 cm in size. No submandibular or cervical lymph nodes were palpable during the physical examination. Abdominal ultrasonography and computed tomography (CT; Brilliance iCT; Philips Medical Systems, Amsterdam, Holland) of the head, neck and thorax demonstrated no evidence of systemic or local metastasis. As presented in Fig. 2, the head and neck CT scans revealed the lesion located in the subcutaneous tissue of the left-upper lip, with a wide base inseparable from overlying skin.An incisional biopsy was performed with the patient under local anesthesia. The diagnosis of the specimen was confirmed as carcinoma. The patient underwent complete surgical resection...

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“…Clinically and histologically, MAC is often misdiagnosed as a benign adnexal neoplasm, basal cell carcinoma, or SCC. 2,3 Although metastasis is exceedingly rare, isolated case reports describing regional lymph node or lung metastasis have been published. 3,13 The microcystic changes seen in our series of SCC of the lung morphologically show a striking resemblance to MAC of the skin.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Although metastasis is exceedingly rare, isolated case reports describing regional lymph node or lung metastasis have been published. 3,13 The microcystic changes seen in our series of SCC of the lung morphologically show a striking resemblance to MAC of the skin. The growth pattern, small cystic spaces in the tumor nests, the often basaloid or clear-appearing keratinocytes, and a dense sclerotic stroma can easily mimic the presence of a glandular neoplasm or adnexal differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…The microcystic change seen in our cases was so pronounced as to mimic glandular and duct-like adnexal differentiation and was strikingly reminiscent of the growth pattern seen in the so-called microcystic adnexal carcinoma (MAC) of the skin, a rare but distinct cutaneous neoplasm with locally aggressive behavior and an ability to give rise to metastasis. 2,3 The importance of the recognition of microcystic changes in SCC of the lung lies in the potential for misdiagnosis as a tumor with a true glandular component or neoplasm of adnexal derivation. We provide a detailed pathologic description to facilitate the differential diagnosis of this unusual variant and its closest mimics.…”

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Microcystic Squamous Cell Carcinoma of the Lung

Weissferdt

Moran

2011

American Journal of Clinical Pathology

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A b s t r a c t Three cases of pulmonary squamous cell carcinoma (SCC) are described displaying a prominent microcystic pattern closely resembling microcystic adnexal carcinoma of the skin (MACSquamous cell carcinoma (SCC) of the lung is a tumor that may show different growth patterns. The main variants include papillary, clear cell, small cell, and basaloid SCC in addition to other less commonly seen patterns. 1 We report 3 cases of an undescribed variant of pulmonary SCC characterized by prominent microcystic changes. The microcystic change seen in our cases was so pronounced as to mimic glandular and duct-like adnexal differentiation and was strikingly reminiscent of the growth pattern seen in the so-called microcystic adnexal carcinoma (MAC) of the skin, a rare but distinct cutaneous neoplasm with locally aggressive behavior and an ability to give rise to metastasis. 2,3 The importance of the recognition of microcystic changes in SCC of the lung lies in the potential for misdiagnosis as a tumor with a true glandular component or neoplasm of adnexal derivation. We provide a detailed pathologic description to facilitate the differential diagnosis of this unusual variant and its closest mimics. Materials and MethodsThree cases of SCC of the lung showing a prominent microcystic growth pattern were identified from the surgical pathology files of the M.D. Anderson Cancer Center, Houston, TX. In each case, 5 or 6 H&E-stained tumor sections from resection specimens were available for review. Clinical and follow-up information was obtained from the patients' charts or from referral information. Results Clinical FeaturesThe clinical features are summarized in ❚Table 1❚. Of the patients, 2 were women and 1 was a man; their age range was

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Microcystic Adnexal Carcinoma: Report of Seven Cases Including One with Lung Metastasis

Cited by 56 publications

References 64 publications

Malignant Skin Neoplasms

Malignant Skin Neoplasms

Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature

Microcystic Squamous Cell Carcinoma of the Lung

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