Microcystic Adnexal Carcinoma: Review of 51 Japanese Patients

Ohtsuka, Hisashi; Nagamatsu, Shogo

doi:10.1159/000057880

Cited by 61 publications

(59 citation statements)

References 11 publications

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“…Other ethnic groups may also be affected, and at least 50 Japanese [ 10 ] and 7 African American patients have been reported in the literature [ 9,[11][12][13][14][15] .…”

Section: Epidemiologymentioning

confidence: 99%

“…In one patient, MAC was diagnosed as the cause of asymptomatic and gradually expanding alopecia which had been present for 31 years [ 13 ] . Also, a review of 50 Japanese patients included a patient who was considered to have had an undiagnosed MAC for 50 years [ 10 ] .…”

Section: Clinical Features and Diagnosismentioning

confidence: 99%

“…Interpretation of the histology may be particularly diffi cult in a small shave or superfi cial punch biopsy in which it is not possible to assess the architectural pattern. In the largest published case series, the diagnosis of MAC was made in only 70% of initial biopsy specimens [ 10,16,17 ] . In periocular skin, this fi gure seems to be even lower, applying to only 19% of all 35 periocular MAC reported in the English language literature [ 35 ] .…”

Section: Histopathological Featuresmentioning

confidence: 99%

“…Of these, 5.8% of tumors persisted (exact 95%; CI, 1.9-13). On the other hand, SSE was used in four studies, with a total of 95 cases and an average follow-up of 6.9 years (range, 4 months-29 years) [ 5,10,19,43 ] . Among these, 32.2% persisted (exact 95%; CI, 22.75-42.9).…”

Section: Treatmentmentioning

confidence: 99%

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Microcystic Adnexal Carcinoma

Παλαμάρας

Barlow

2011

Mohs Micrographic Surgery

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Microcystic adnexal carcinoma (MAC) is a rare adnexal tumor often found on the head and neck and usually presenting as an ill-defi ned, yellowish, or faintly erythematous plaque. It is characterized by aggressive local infi ltration and has a high propensity for perineural invasion (PNI).Most cases have been reported in white patients aged 40-60 years, and there is no sexual predilection. The tumor also occurs in other ethnic groups and across a much wider age range.An adequately sized biopsy is necessary for diagnosis. Surgery is the treatment of choice. The poorly defi ned clinical margins and propensity for perineural spread make Mohs micrographic surgery (MMS) preferable to standard surgical excision. When nerve involvement is present, MMS with formalin-fi xed, paraffi n-embedded sections should be considered.The prognosis is good, and the 10-year survival rate is higher than 85%. Metastases are rare.

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“…Other ethnic groups may also be affected, and at least 50 Japanese [ 10 ] and 7 African American patients have been reported in the literature [ 9,[11][12][13][14][15] .…”

Section: Epidemiologymentioning

confidence: 99%

Section: Clinical Features and Diagnosismentioning

confidence: 99%

Section: Histopathological Featuresmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

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Microcystic Adnexal Carcinoma

Παλαμάρας

Barlow

2011

Mohs Micrographic Surgery

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“…Local recurrence rates are approximately 50%. [210][211][212][213][214] Occasionally, the lesion will appear in unusual locations and settings, such a recent case arising in the external auditory canal 15 years after radiotherapy of a nasopharyngeal carcinoma that had occurred in a 12-year boy. 215 Another patient showed the synchronous development of a microcystic adnexal carcinoma with a gastric carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma

Worley

Owen²,

Barker

et al. 2019

JAMA Dermatol

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IMPORTANCE Microcystic adnexal carcinoma (MAC) occurs primarily in older adults of white race/ethnicity on sun-exposed skin of the head and neck. There are no formal guiding principles based on expert review of the evidence to assist clinicians in providing the highest-quality care for patients. OBJECTIVE To develop recommendations for the care of adults with MAC.EVIDENCE REVIEW A systematic review of the literature (1990 to June 2018) was performed using MEDLINE, Embase, Web of Science, and the Cochrane Library. The keywords searched were microcystic adnexal carcinoma, sclerosing sweat gland carcinoma, sclerosing sweat duct carcinoma, syringomatous carcinoma, malignant syringoma, sweat gland carcinoma with syringomatous features, locally aggressive adnexal carcinoma, and combined adnexal tumor. A multidisciplinary expert committee critically evaluated the literature to create recommendations for clinical practice. Statistical analysis was used to estimate optimal surgical margins.

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Microcystic Adnexal Carcinoma: Review of 51 Japanese Patients

Cited by 61 publications

References 11 publications

Microcystic Adnexal Carcinoma

Microcystic Adnexal Carcinoma

Malignant adnexal neoplasms

Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma

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