Microcystic adnexal carcinoma: unusual presentation

Jfri, Abdulhadi; Hawsawi, Khalid Al; Marghalani, Siham; Alkhuzaie, A.

doi:10.1111/jdv.12659

Cited by 5 publications

(11 citation statements)

References 10 publications

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“…It often presents as an indolent, non-ulcerated, smooth-surfaced, flesh-colored to yellowish asymptomatic nodule, papule, plaque, or cystic lesion with indistinct margins with a predilection for the head and neck, predominantly arising in the central face. 1,4,[11][12][13][14][15][16][17][18] It is paramount to include MAC as a differential diagnosis among the other head and neck lesions to enable early diagnosis and treatment to reduce morbidity and mortality. Deep incisional or excisional biopsy for histopathology is the gold standard for initial diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Deep incisional or excisional biopsy for histopathology is the gold standard for initial diagnosis. 16,17 Mohs is considered the gold standard of treatment for MAC. To date, there is insufficient evidence whether radiation is an effective monotherapy in patients with MAC due to rarity of the disease and the limited use as a management option.…”

Section: Discussionmentioning

confidence: 99%

“… 1 – 26 It is characterized as a malignant, aggressive, and locally invasive tumor with a high recurrence rate. 2 – 4 , 8 , 9 , 11 – 17 , 19 MAC typically does not metastasize; however, there are reports of local and distant progression of the disease. 1 , 13 , 15 Although recognized as a distinct clinicopathologic entity, 3 MAC has proven to be diagnostically challenging as it can mimic other similar neoplasms.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 13 , 15 Although recognized as a distinct clinicopathologic entity, 3 MAC has proven to be diagnostically challenging as it can mimic other similar neoplasms. 3 , 6 , 16 , 17 Consequently, in addition to its rarity, there is often inadequate initial treatment. Clinically, MAC typically manifests as an indurated, growing flesh-colored plaque although variations of clinical morphology have been reported.…”

Section: Introductionmentioning

confidence: 99%

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An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

Hinther

Henni

Asiniwasis

2020

SAGE Open Medical Case Reports

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Microcystic adnexal carcinoma is a rare cutaneous neoplasm believed to arise from pluripotent keratinocytes capable of adnexal differentiation. Due to its insidious growth and appearance, diagnosis is often delayed. A deep incisional or excisional biopsy for histopathology is the gold standard for diagnosis. Different treatment modalities have been described in the literature, including the Mohs micrographic surgery, standard excision, radiation, chemotherapy, and observation. Currently, Mohs remains the treatment of choice. We present a unique case of a 12-month history of an extensive progressive centrofacial cutaneous induration diagnosed as microcystic adnexal carcinoma in an 83-year-old female. Due to the extensive nature of the tumor, she received radiation therapy and continues to receive ongoing assessment with no evidence of clinical recurrence at 2-year post-treatment including negative scouting biopsies. To date, there is no consensus on the optimal treatment for microcystic adnexal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

Hinther

Henni

Asiniwasis

2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

show abstract

“…The diagnosis of microcystic adnexal carcinoma was made. It is important to know the various clinical presentations of microcystic adnexal carcinoma, including the features of this case …”

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confidence: 99%