Microcystin accumulation in liver and muscle of tilapia in two large Brazilian hydroelectric reservoirs

Deblois, Charles P.; Aranda-Rodriguez, Rocio; Giani, Alessandra; Bird, David F.

doi:10.1016/j.toxicon.2007.10.017

Cited by 77 publications

(55 citation statements)

References 39 publications

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“…MCs accumulation and depuration in tissues of fish and other aquatic organisms have been investigated in many studies Pires et al, 2004;Xie et al, 2004;Deblois et al, 2008). In hybrid sturgeon, MCs could also be accumulated in liver, whole intestine, and dorsal white muscle, which was consistent with the previous studies in other fish species (Soares et al, 2004;Zhao et al, 2006), mussels (Amorim and Vasconcelos, 1999), shrimps , and snails .…”

Section: Microcystins Accumulation and Depuration In Fish Tissuesupporting

confidence: 82%

“…In hybrid sturgeon, MCs concentration in liver of fish fed low level cyanobacteria diet was more than 400 ng/g DW after a 47-day MCs exposure. Compared with the concentrations reported in natural MCs accumulation in fish liver of different species, the present levels were lower (Magalhães et al, 2001;Deblois et al, 2008) or in the same range (Mohamed et al, 2003;Zhao et al, 2006). According to our results, high levels of MCs could be accumulated in fish tissue both at the low level and the high level cyanobacteria diets.…”

Section: Microcystins Accumulation and Depuration In Fish Tissuecontrasting

confidence: 64%

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Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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A 90-day growth trial was conducted on hybrid sturgeon (Acipenser baeri $ 3 A. gueldenstaedtii #) to investigate the effect of dietary inclusion of cyanobacteria on growth, feed utilization, and fish tissue microcystins (MCs) accumulation and the recovery of fish when they were free of cyanobacteria. Four diets were formualted isonitrogenous and isocaloric to contain different MCs concentrations: the control diet (free of cyanobacteria), low cyanobacteria diet (LCD, 26.60 lg MCs/g diet), medium cyanobacteria diet (MCD, 78.82 lg MCs/g diet), and high cyanobacteria diet (HCD, 201.03 lg MCs/g diet). During the first 47 days, each diet was fed to fish in five replicates and then all fish were fed the control diet during the next 43 days. The results showed that a dose-dependent decrease in feeding rate (FR) and specific growth rate (SGR) were observed in the fish fed with MCD and HCD. MCs contents in fish liver, intestine, and dorsal white muscle increased with dietary MCs and were time dependent (P \ 0.05). After the 43-day recovery, there were no significant differences in FR or SGR between the fish previously fed LCD or MCD and the fish fed with the control diet (P [ 0.05), while the fish previously fed HCD showed higher FR and SGR than those fed the control diet (P \ 0.05). MCs clearance in fish liver and intestine showed time-dependence during the 43-day recovery. # 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 161-170, 2011.

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Section: Microcystins Accumulation and Depuration In Fish Tissuesupporting

confidence: 82%

Section: Microcystins Accumulation and Depuration In Fish Tissuecontrasting

confidence: 64%

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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“…However, most of the species are aquatic, being part of periphytic and phytoplanktonic communities in marine and freshwater environments (Komárek and Anagnostidis, 2005 Komárek, among others (Carmichael, 1992;Sivonen and Jones, 1999). These metabolites are the most studied cianotoxins due to their wide distribution in the world and because of their toxicity to humans (Jochimsen et al, 1998;Chen et al, 2009;Giannuzzi et al, 2011), domestic animals (Wood et al, 2010), livestock (Orr et al, 2003), as well as organisms from the aquatic biota (Deblois et al, 2008;Lance et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Phytotoxicity associated to microcystins: a review

et al. 2014

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Microcystins (MC) are the most studied toxins of cyanobacteria since they are widely distributed and account for several cases of human and animal poisoning, being potent inhibitors of the serine/threonine protein phosphatases 1 (PP1) and 2A (PP2A). The phosphatases PP1 and PP2A are also present in plants, which may also suffer adverse effects due to the inhibition of these enzymes. In aquatic plants, biomass reduction is usually observed after absorption of cyanotoxins, which can bioaccumulate in its tissues. In terrestrial plants, the effects caused by microcystins vary from inhibition to stimulation as the individuals develop from seedling to adult, and include reduction of protein phosphatases 1 and 2A, oxidative stress, decreased photosynthetic activity and even cell apoptosis, as well as bioaccumulation in plant tissues. Thus, the irrigation of crop plants by water contaminated with microcystins is not only an economic problem but becomes a public health issue because of the possibility of food contamination, and this route of exposure requires careful monitoring by the responsible authorities.Keywords: bioaccumulation, microcystins effects, crop plants, aquatic plants. Fitotocixidade associada às microcistinas: uma revisão ResumoMicrocistinas (MC) são as toxinas de cianobactérias mais estudadas, uma vez que são amplamente distribuídas e responsáveis por vários casos de intoxicação humana e animal. São potentes inibidoras das proteínas fosfatases serina/treonina 1 (PP1) e 2A (PP2A). As fosfatases PP1 e PP2A também estão presentes em plantas, as quais podem sofrer efeitos adversos devido à inibição dessas enzimas. Em plantas aquáticas, a redução da biomassa é geralmente observada após absorção de cianotoxinas que podem bioacumular em seus tecidos. Em plantas terrestres, os efeitos causados pelas microcistinas variam de inibição ao estímulo, como no desenvolvimento de plântulas ao estádio adulto, e incluem a redução de proteínas fosfatases 1 e 2A, estresse oxidativo, diminuição da atividade fotossintética e até mesmo apoptose celular, bem como a bioacumulação em tecidos de plantas. Assim, a irrigação de plantas cultivadas com água contaminada com microcistina não é apenas um problema econômico, mas torna-se um problema de saúde pública, devido à possibilidade de contaminação dos alimento, sendo uma via de exposição que requer um monitoramento cuidadoso por parte das autoridades responsáveis.Palavras-chave: bioacumulação, efeitos de microcistinas, plantas da agricultura, plantas aquáticas.

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“…MC average values in fi sh muscles were (7.1±2.5) ng g -1 , while the concentrations found in several lakes exceeded the WHO TDI. According to the authors, a healthy 60 kg person who consumed a 300 g serving of C. gibelio on average daily would be at risk, even more so in the case of the elderly, children, or sensitive individuals (75 at the Furnas reservoir) were below the WHO guideline for drinking water, the MCs in the fi sh had accumulated to toxic levels (76). It has also been found that different species of fi sh accumulate different amounts of MCs.…”

Section: Cyanobacterial Toxicity Through the Aquatic Food Webmentioning

confidence: 99%

Human Exposure to Cyanotoxins and their Effects on Health

Drobac

Tokodi

Simeunović

et al. 2013

Archives of Industrial Hygiene and Toxicology

115

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Cyanotoxins are secondary metabolites produced by cyanobacteria. They pose a threat to human health and the environment. This review summarises the existing data on human exposure to cyanotoxins through drinking water, recreational activities (e.g., swimming, canoeing or bathing), the aquatic food web, terrestrial plants, food supplements, and haemodialysis. Furthermore, it discusses the tolerable daily intake and guideline values for cyanotoxins (especially microcystins) as well as the need to implement risk management measures via national and international legislation.

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Microcystin accumulation in liver and muscle of tilapia in two large Brazilian hydroelectric reservoirs

Cited by 77 publications

References 39 publications

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Phytotoxicity associated to microcystins: a review

Human Exposure to Cyanotoxins and their Effects on Health

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