Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ)

Magalhães, Valéria Freitas de; Marinho, Marcelo Manzi; Domingos, Patrícia; Oliveira, Andréa C.; Costa, Simone M. da; Azevedo, Luiz Otávio; Azevedo, Sandra M.F.O.

doi:10.1016/s0041-0101(03)00144-2

Cited by 226 publications

(135 citation statements)

References 22 publications

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“…Moreover, MCs accumulation in liver, whole intestine, and dorsal white muscle showed a dose-dependent manner and a time-dependent manner with the prolonged exposure duration during the accumulation period. In fact, faced with subchronic dietary MCs exposure, hybrid sturgeon cannot avoid the ingestion of toxins, which could result in MCs accumulation in fish tissues (Magalhães et al, 2001(Magalhães et al, , 2003Li et al, 2004;Zhao et al, 2006). Previous study suggested that retention of MCs by the liver is dependent on whether the liver had suffered damage (Runnegar et al, 1986).…”

Section: Microcystins Accumulation and Depuration In Fish Tissuementioning

confidence: 99%

“…More importantly, cyanobacteria are an important dietary component for many fish species (e.g., Tilapia) (Zurawell et al, 2005). In addition, MCs are rarely ingested by human in amount high enough for a lethal acute dose, but the toxicity caused by chronic effect is particularly more probable if there is longterm frequent exposure (Magalhães et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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A 90-day growth trial was conducted on hybrid sturgeon (Acipenser baeri $ 3 A. gueldenstaedtii #) to investigate the effect of dietary inclusion of cyanobacteria on growth, feed utilization, and fish tissue microcystins (MCs) accumulation and the recovery of fish when they were free of cyanobacteria. Four diets were formualted isonitrogenous and isocaloric to contain different MCs concentrations: the control diet (free of cyanobacteria), low cyanobacteria diet (LCD, 26.60 lg MCs/g diet), medium cyanobacteria diet (MCD, 78.82 lg MCs/g diet), and high cyanobacteria diet (HCD, 201.03 lg MCs/g diet). During the first 47 days, each diet was fed to fish in five replicates and then all fish were fed the control diet during the next 43 days. The results showed that a dose-dependent decrease in feeding rate (FR) and specific growth rate (SGR) were observed in the fish fed with MCD and HCD. MCs contents in fish liver, intestine, and dorsal white muscle increased with dietary MCs and were time dependent (P \ 0.05). After the 43-day recovery, there were no significant differences in FR or SGR between the fish previously fed LCD or MCD and the fish fed with the control diet (P [ 0.05), while the fish previously fed HCD showed higher FR and SGR than those fed the control diet (P \ 0.05). MCs clearance in fish liver and intestine showed time-dependence during the 43-day recovery. # 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 161-170, 2011.

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Section: Microcystins Accumulation and Depuration In Fish Tissuementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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“…In the natural environment, MCs accumulate in a wide range of aquatic animals, including fish (Magalhães et al, 2003;Mohamed et al, 2003), shrimps (Chen and Xie, 2005b), gastropods (Chen and Xie, 2005b;Zhang et al, 2012;Zurawell et al, 1999) and bivalves (Chen and Xie, 2005a;Williams et al, 1997). MCs are found in both the viscera and also in the edible muscle/foot.…”

Section: Introductionmentioning

confidence: 99%

“…Field studies have been conducted in Brazil (Magalhàes et al, 2001), Egypt (Mohamed et al, 2003), Argentina (Ame et al, 2010) and Portugal (Vasconcelos and Pereira, 2001). Currently, studies of MCs in fish have focused on its accumulation in muscle and liver (Cazenave et al, 2005;Magalhães et al, 2003;Magalhaes et al, 2001;Mohamed et al, 2003) because humans eat the muscle, whereas the liver accumulates the highest concentrations of MCs. However, few studies have simultaneously evaluated multiple fish organs, such as the gut, kidney and heart, which may also accumulate MCs and affect the health of aquatic animals.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

Jia

Luo

Lü

et al. 2014

Science of The Total Environment

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Microcystins (MCs) are the toxic products of harmful algal blooms and they accumulate in fish. The accumulation of MCs in fish living in different trophic levels from different parts of Lake Taihu was determined. This information was then used to evaluate the risks posed by the MCs in fish to human health. The concentrations of three MCs, MC-LR, MC-YR and MC-RR, were quantified in the following four fish species: silver carp (Hypophthalmichthys molitrix), bighead carp (Aristichthys nobilis), crucian carp (Carassius auratus) and common carp (Cyprinus carpio), using high performance liquid chromatography interfaced with tandem (triple quadrupole) mass spectrometry. The mean concentrations of MCs in the muscle, the kidney, the intestinal wall and the heart were significantly different among the four fishes except in the liver. C. carpio contained the highest mean concentration of MCs in the muscle (31.7 ± 12.1 ng/g, dry mass (dm)), whereas C. auratus had the highest mean concentrations of MCs in the liver (45.4 ± 44.5 ng/g, dm), kidney (114 ± 51.1 ng/g, dm), intestinal wall (2.04 × 10 3 ± 4.43 × 10 3 ng/g, dm) and heart (59.5 ± 26.7 ng/g, dm). The mean concentration of MCs in the intestinal walls of the fish species was significantly higher than in other organs (p b 0.01). The fish from Meiliang Bay had significantly higher concentrations of MCs than those from the centre, west or south banks of the lake (p b 0.01). The body lengths and masses of the fish were negatively correlated with the concentrations of MCs in the kidney (p b 0.05) and heart (p b 0.01). The average daily intake (ADI) of MCs in the muscle of all fishes exceeded the provisional tolerable daily intake (TDI) set by World Health Organization. The estimated daily intakes of MCs in 55.6% of the muscle samples exceeded the TDI. The MCs in the tissues of the fish from Lake Taihu pose potential risks to the health of humans who consume these four fish species.

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“…3 Bioaccumulation of microcystins in fish has been reported, so exposure to contaminated food is another major public health concern. 4,5 Thus, sensitive and robust analytical methods are required for detection of microcystins in waters at risk of algal blooms. ELISA diagnostic kits for microcystins are commercially available, and have been used for analysis of toxins in water.…”

Section: Int J Occup Environ Health 2006;12:377-385mentioning

confidence: 99%

ITREOH Building of Regional Capacity to Monitor Recreational Water: Development of a Non-commercial Microcystin ELISA and Its Impact on Public Health Policy

Brena

Díaz

Sienra

et al. 2006

International Journal of Occupational and Environmental Health

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Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ)

Cited by 226 publications

References 22 publications

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

ITREOH Building of Regional Capacity to Monitor Recreational Water: Development of a Non-commercial Microcystin ELISA and Its Impact on Public Health Policy

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