Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling

Karimipour, Darius J.; Kang, Sewon; Johnson, Timothy M.; Orringer, Jeffrey S.; Hamilton, Ted A.; Hammerberg, Craig; Voorhees, John J.; Fisher, Gary J.

doi:10.1016/j.jaad.2005.11.1084

Cited by 36 publications

(17 citation statements)

References 17 publications

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“…22,30 These studies demonstrate that superficial abrasion of the epidermis stimulates MMP and collagen production. These findings suggest that interventions acting purely on epidermal keratinocytes may lead to the production of soluble factors that drive dermal changes.…”

Section: Discussionmentioning

confidence: 82%

Intraepidermal erbium:YAG laser resurfacing

Orringer

Rittié

Hamilton

et al. 2011

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 82%

Intraepidermal erbium:YAG laser resurfacing

Orringer

Rittié

Hamilton

et al. 2011

Journal of the American Academy of Dermatology

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“…Prior work at our institution has demonstrated the ability to quantify cutaneous responses to various aesthetic interventions . Our data suggest that the magnitudes of specific molecular responses are predictive of the clinical efficacy of a given treatment intended to improve the texture of photodamaged skin.…”

mentioning

confidence: 78%

Direct Quantitative Comparison of Molecular Responses in Photodamaged Human Skin to Fractionated and Fully Ablative Carbon Dioxide Laser Resurfacing

Orringer

Sachs

Shao

et al. 2012

Dermatologic Surgery

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The fundamental cutaneous responses that result from fully ablative and fractionated carbon dioxide laser resurfacing are similar but differ in magnitude and duration, with the fully ablative procedure inducing relatively greater changes including more pronounced collagen induction. However, the molecular data reported here provide substantial support for fractionated ablative resurfacing as an effective treatment modality for improving skin texture.

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“…In conventional use, microdermabrasion is a cosmetic procedure that improves the appearance of superficial skin defects such as fine lines, wrinkles, and scars by abrading the stratum corneum with pressurized particles (4)(5)(6)(7)(8)(9). The depth of abrasion employed depends on the severity of the patient's skin condition, but in a clinical setting, the stratum corneum is not usually completely removed (6).…”

Section: Introductionmentioning

confidence: 99%

Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion

2011

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Abstract. Microdermabrasion is widely used as a non-invasive cosmetic technique that has recently been adapted to selectively remove stratum corneum to increase skin permeability for transdermal drug delivery. This study measured the kinetics of skin barrier recovery after stratum corneum removal using microdermabrasion in hairless guinea pigs. The skin was abraded at two sites on each animal, one of which was allowed to recover under occlusion while the other remained non-occluded. Histological measurements showed that skin barrier properties to sulforhodamine B largely recovered within 12 h, and the stratum corneum appeared largely reformed within 24 h for both occluded and non-occluded skin. Skin electrical resistance measurements showed significant recovery of the skin barrier within 24 h. We conclude that transdermal drug delivery may occur for up to 12 h after microdermabrasion in guinea pigs; however, humans will probably have a longer recovery time due to expected slower skin healing rates.

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Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling

Cited by 36 publications

References 17 publications

Intraepidermal erbium:YAG laser resurfacing

Intraepidermal erbium:YAG laser resurfacing

Direct Quantitative Comparison of Molecular Responses in Photodamaged Human Skin to Fractionated and Fully Ablative Carbon Dioxide Laser Resurfacing

Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion

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