Microdomains and stress distributions in bacterial monolayers on curved interfaces

Langeslay, Blake; Juárez, Gabriel

doi:10.1039/d2sm01498j

Cited by 7 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 2019 )), depending on local physical factors such as substrate curvature (Schamberger et al. ( 2023 ); Langeslay and Juarez ( 2023 )), structural anisotropy (Vallespir Lowery and Ursell ( 2019 )), and substrate stiffness (Lin et al. ( 2020 ); Sengupta ( 2020 ); Asp et al.…”

Section: Introductionmentioning

confidence: 99%

Microbes in porous environments: from active interactions to emergent feedback

Jin,

Sengupta

2024

Biophys Rev

View full text Add to dashboard Cite

Microbes thrive in diverse porous environments—from soil and riverbeds to human lungs and cancer tissues—spanning multiple scales and conditions. Short- to long-term fluctuations in local factors induce spatio-temporal heterogeneities, often leading to physiologically stressful settings. How microbes respond and adapt to such biophysical constraints is an active field of research where considerable insight has been gained over the last decades. With a focus on bacteria, here we review recent advances in self-organization and dispersal in inorganic and organic porous settings, highlighting the role of active interactions and feedback that mediates microbial survival and fitness. We discuss open questions and opportunities for using integrative approaches to advance our understanding of the biophysical strategies which microbes employ at various scales to make porous settings habitable.

show abstract

Section: Introductionmentioning

confidence: 99%

Microbes in porous environments: from active interactions to emergent feedback

Jin,

Sengupta

2024

Biophys Rev

View full text Add to dashboard Cite

show abstract

Collective mechano-response dynamically tunes cell-size distributions in growing bacterial colonies

Wittmann,

Nguyen,

Löwen

et al. 2023

Commun Phys

View full text Add to dashboard Cite

Mechanical stresses stemming from environmental factors are a key determinant of cellular behavior and physiology. Yet, the role of self-induced biomechanical stresses in growing bacterial colonies has remained largely unexplored. Here, we demonstrate how collective mechanical forcing plays an important role in the dynamics of the cell size of growing bacteria. We observe that the measured elongation rate of well-nourished Escherichia coli cells decreases over time, depending on the free area around each individual, and associate this behavior with the response of the growing cells to mechanical stresses. Via a cell-resolved model accounting for the feedback of collective forces on individual cell growth, we quantify the effect of this mechano-response on the structure and composition of growing bacterial colonies, including the local environment of each cell. Finally, we predict that a mechano-cross-response between competing bacterial strains with distinct growth rates affects their size distributions.

show abstract