Microdosimetry of Internal Sources

Roesch, W. C.

doi:10.2307/3574640

Cited by 44 publications

(29 citation statements)

References 9 publications

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“…Therefore, no single value of energy or LET adequately describes the nature of the α-particle field to which the cells are exposed. In view of these considerations, a full microdosimetric analysis taking into account the finer aspects of target size, source distribution at the cellular level, hit probability, etc., is needed to obtain a better understanding of the RBE of incorporated radionuclides in vivo (39,41,42). The mouse testis model used in the present studies is not readily amenable to a microdosimetric analysis.…”

Section: Influence Of Microscopic Distribution Of Radioactivity On Rbementioning

confidence: 91%

Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses

Howell¹,

Azure²,

Narra³

et al. 1994

Radiation Research

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The therapeutic potential of radionuclides that emit α particles, as well as their associated health hazards, have attracted considerable attention. The 224 Ra daughters 212 Pb and 212 Bi, by virtue of their radiation properties which involve emission of α and β particles in their decay to stable 208 Pb, have been proposed as candidates for radioimmunotherapy. Using mouse testes as the experimental model and testicular spermhead survival as the biological end point, the present work examines the radiotoxicity of 212 Pb and its daughters. When 212 Pb, in equilibrium with its daughters 212 Bi, 212 Po and 208 Tl, was administered directly into the testis, the dose required to achieve 37% survival (D 37 ) was 0.143 ± 0.014 Gy and the corresponding RBE of the mixed radiation field was 4.7 when compared to the D 37 for acute external 120 kVp X rays. This datum, in conjunction with our earlier results for 210 Po, was used to obtain an RBE-LET relationship for α particles emitted by tissue-incorporated radionuclides: RBE α = 4.8 − 6.1 × 10 −2 LET + 1.0 × 10 −3 LET 2 . Similarly, the dependence of RBE on α-particle energy E α was given by . These relationships, based on in vivo experimental data, may be valuable in predicting biological effects of α-particle emitters.

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Section: Influence Of Microscopic Distribution Of Radioactivity On Rbementioning

confidence: 91%

Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses

Howell¹,

Azure²,

Narra³

et al. 1994

Radiation Research

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“…Other exceptions are a-or ß-emitting hot spots. These exceptional cases (see, e.g., [11][12][13]) are not treated in this chapter, but they can be of considerable radiobiological interest. Figure 1 serves as a rough illustration of the configuration of charged particle tracks.…”

Section: Nature Of the Problemmentioning

confidence: 99%

Fundamentals of Microdosimetry

Kellerer¹

1985

The Dosimetry of Ionizing Radiation

103

110

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“…Concurrently, the Dosimetry Technology Section will develop cell and tissue models in which those methods will be applied. Computational methods for determining the microdosimetryof internally deposited alpha-emitting radionuclides were developed by W. C. Roesch to deal with the random nature of energy deposition in small tissue volumes (Roesch 1977). These complicated mathematical methods require the use of a large computer.…”

Section: • Microdosimetry Of Internal Sourcesmentioning

confidence: 99%

“…The solution also contained 5 x 10 6 macrophage cells/ml, which were assumed to be randomly mixed with the 241Am02 particulates. Using computational methods developed at this laboratory (Roesch 1977), the frequency distribution of specific energies (the average of which is the average absorbed dose) was calculated. Following the completion of this study, the effect of different concentrations of 241Am upon the specific energy distribution to the cells will be evaluated.…”

Section: • Dosimetry Of Internal Emittersmentioning

confidence: 99%

Pacific Northwest Laboratory Annual Report for 1979 to the DOE Assistant Secretary for Environment Part 4 Physical Sciences

Nielsen¹

1980

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NO T I CEThis report was prepared as an account of work spon sore d by the United Stat es Gove rnme nt. Neithe r the Uni ted States nor the Dep.a rt ment of Ene rgy, nor any of the ir employees, nor an y of their contractors, subcontractors, or their employees, makes a ny wa rran ty, ex press or im pli ed, o r assumes an y legal liability or responsibility for the accuracy, com plete ne ss or usefu lne ss of any information, appa ratus, prod uct or process disclosed, or represents that its use wo uld not infri nge priva te ly o wne d rights.The vi e ws, opinions and co ncl us ions con ta ined in thi s repo rt are those of the contractor and do not necessa rily represent those o f the Activities of the scientists whose work is described in this annual report are broader in scope than the articles indicate. PNL staff have responded to numerous requests from DOE during the year for planning, for service on various task groups, and for special assistance.

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Microdosimetry of Internal Sources

Cited by 44 publications

References 9 publications

Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses

Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses

Fundamentals of Microdosimetry

Pacific Northwest Laboratory Annual Report for 1979 to the DOE Assistant Secretary for Environment Part 4 Physical Sciences

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