Midcontinent seismicity presents an uncertain level of hazard to people and infrastructure. While the causes behind intraplate earthquakes in the Central Great Plains region of South Dakota, Nebraska, and Kansas are not fully understood, potential factors of seismicity include the interplay of underlying tectonic structures, regional stresses, and oil production. This project analyzes seismic data collected from the Incorporated Research Institutions for Seismology (IRIS) and other historic data including data from the South Dakota, Kansas, and Nebraska Geological Surveys, to identify and quantify earthquake clusters. A point density analysis of 898 earthquake events shows clusters that can be associated with the Colorado Lineament, Nemaha Ridge, and oil production. Magnitude-weighted kernel density analysis of the earthquakes was conducted in an attempt to identify clusters on the basis of total previous energy released, and, in light of the results, reconsider seismic risk. Temporal animation of the events revealed a propagation sequence along a fault in southwestern Nebraska. This project could help geologists understand spatial and temporal distribution of midcontinent seismic activity.