Microecological state of the gut after correction of stress-induced dysbiosis by peptide Thr-Lys-Pro-Arg-Pro-Gly-Pro

Abstract

Stress can disrupt bidirectional communication within the framework of the microbiota-gut-brain axis, including affecting the microbiological landscape and morphofunctional state of the mucous membrane of the colon. In this work we studied the ability of the peptide Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin-pgp) to correct the state of stress-induced dysbiosis in doses of 80, 250 and 750 pg/kg. The increase in the specific content, frequency of occurrence and relative average value of opportunistic bacteria of control stressed animals noted in the study with a decrease in the number and proportion of obligate bacteria indicated active colonization of the mucous membrane of the colon by them. Administration of tuftsin-pgp dose-dependently changed the qualitative and quantitative composition of the studied biotope microbiota. We found out that the most pronounced positive effect on the signs of stress-induced dysbiosis was the administration of the peptide at a dose of 250 pg/kg.