Microelectrodes, Microelectronics, and Implantable Neural Microsystems

Wise, K.D.; Sodagar, Amir M.; Yao, Ying; Gulari, Mayurachat Ning; Perlin, Gayatri E.; Najafi, K.

doi:10.1109/jproc.2008.922564

Cited by 309 publications

(202 citation statements)

References 74 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…Some of most advanced silicon designs include double-sided, high-density arrays 29,102 , three-dimensional arrangements 43 , and integrated electronics 39,40,132 . Although the inherent brittleness of silicon is a concern for some clinical applications, its electrical, mechanical, and thermal properties offer the greatest design options and are supported by a wide range of commercial microfabrication tools.…”

Section: Substrate Materials and Microfabricationmentioning

confidence: 99%

State-of-the-art MEMS and microsystem tools for brain research

et al. 2017

View full text Add to dashboard Cite

Mapping brain activity has received growing worldwide interest because it is expected to improve disease treatment and allow for the development of important neuromorphic computational methods. MEMS and microsystems are expected to continue to offer new and exciting solutions to meet the need for high-density, high-fidelity neural interfaces. Herein, the state-of-the-art in recording and stimulation tools for brain research is reviewed, and some of the most significant technology trends shaping the field of neurotechnology are discussed.

show abstract

Section: Substrate Materials and Microfabricationmentioning

confidence: 99%

State-of-the-art MEMS and microsystem tools for brain research

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A sensor site and the surrounding stimulation site can be seen in Fig. 1b Besides the comparably large, planar in-vitro systems, which are in the focus of this contribution, there are also CMOS-based needle-type probes for recording and stimulation in vivo that have been pioneered at the University of Michigan [3,[29][30][31][32][33] and adopted by other groups ( Figure 2) [34][35][36][37]. Such electrode arrays are inserted into the living brain and facilitate advances in the understanding of the nervous system.…”

Section: Cmos High-density Systemsmentioning

confidence: 99%

“…Such electrode arrays are inserted into the living brain and facilitate advances in the understanding of the nervous system. Merged with onchip circuitry, signal processing, microfluidics, and wireless interfaces, they are forming the basis for a family of neural prostheses for the possible treatment of disorders, such as blindness, deafness, paralysis, severe epilepsy, and Parkinson's disease [31].…”

Section: Cmos High-density Systemsmentioning

confidence: 99%

Direct interfacing of neurons to highly integrated microsystems

Hierlemann

2017

2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)

View full text Add to dashboard Cite

The use of large high-density transducer arrays enables fundamentally new neuroscientific insights through enabling high-throughput monitoring of action potentials of larger neuronal networks (> 1000 neurons) over extended time to see effects of disturbances or developmental effects, and through facilitating detailed investigations of neuronal signaling characteristics at subcellular level, for example, the study of axonal signal propagation that has been largely inaccessible to established methods. Applications include research in neural diseases and pharmacology.

show abstract

“…For the fabrication of neural systems with high-density electrodes, precision machining is increasingly being replaced by microelectromechanical systems (MEMS) technologies (Alivisatos et al 2013). In general, these MEMS-based devices rely on polymers (Stieglitz et al 2005) or silicon Wise et al 2008) as substrate materials, with the latter enabling the co-integration of electrodes with complementary metal-oxide semiconductor (CMOS) integrated circuits performing data preprocessing and multiplexing tasks.…”

Section: Introductionmentioning

confidence: 99%

Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies

Ayub

Gentet

Fiáth

et al. 2017

Biomed Microdevices

View full text Add to dashboard Cite

This article reports on the development, i.e., the design, fabrication, and validation of an implantable optical neural probes designed for in vivo experiments relying on optogenetics. The probes comprise an array of ten bare light-emitting diode (LED) chips emitting at a wavelength of 460 nm and integrated along a flexible polyimidebased substrate stiffened using a micromachined ladder-like silicon structure. The resulting mechanical stiffness of the slender, 250-μm-wide, 65-μm-thick, and 5-and 8-mm-long probe shank facilitates its implantation into neural tissue.

show abstract

Microelectrodes, Microelectronics, and Implantable Neural Microsystems

Cited by 309 publications

References 74 publications

State-of-the-art MEMS and microsystem tools for brain research

State-of-the-art MEMS and microsystem tools for brain research

Direct interfacing of neurons to highly integrated microsystems

Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies

Contact Info

Product

Resources

About