Microelimination of HCV in residual populations of coinfected HIV/HCV: real-life data from an hospital setting in Southern Italy

Fusco, Francesco; Iodice, V.; Flumeri, Giuseppe Di; Parrella, Giovanni; Pisaturo, M.; Tambaro, Orsola; Viglietti, Rosaria; Chirianni, Antonio; Sangiovanni, Vincenzo

doi:10.1016/j.dld.2019.12.104

Cited by 2 publications

(5 citation statements)

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“…The sustained high weekly prevalence rates of SARS-CoV-2 infection among symptomatic HCWs observed in our study (from 22.3% to 55.9%), when compared to similar studies from Asia, Europe and US [11][12][13][14][20][21][22] is concerning ( gure1). The majority of our cohort had a mild illness, which could potentially represent a risk of continued routine of working throughout the illness, facilitating the transmission of the virus into the hospital to patients and other HCWs.…”

Section: Discussionsupporting

confidence: 59%

“…This nding may represent a signi cant risk of increasing transmission. Similar studies in Europe demonstrated that a high proportion of HCWs maintained their work routine in the hospital even presenting mild symptoms [11][12][13]. These ndings highlight the importance of having not only well-stablished guidance for all HCWs on the use of PPE, but also clear recommendations on sick leave policies for all HCWs with suspected COVID-19.…”

Section: Discussionsupporting

confidence: 56%

“…Although several studies already investigated the epidemiology of and risk factors for SARS-CoV-2 infection among HCWs in high-income countries, there is a lack of data from low and middle-income countries, where shortage of personal protective equipment (PPE), diagnostic tests and other vital supplies represent one of the most urgent challenges faced by public health systems [4][5][6][7][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

Buonafine

Paiatto

Leal

et al. 2020

Preprint

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Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21 st and May 22 nd , 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 (9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariate analysis, using logistic regression, anosmia (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male) and 2 (1.6%) died. Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

Buonafine

Paiatto

Leal

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This nding may represent a signi cant risk of increasing transmission. Similar studies in Europe demonstrated that a high proportion of HCWs maintained their work routine in the hospital even presenting mild symptoms [11][12][13]. At the time the study was conducted, the o cial policy in the hospital recommended that symptomatic HCWs should be immediately excluded from the workplace for a minimum of 14 days.…”

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

Buonafine

Paiatto

Leal

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Brazil became the epicenter of the COVID-19 pandemic in Latin America since May 2020, reporting the highest number of cases and deaths in the region. Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of HCWs with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among HCWs with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic HCWs tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (95% CI 15.9% - 60.3%) in the second week to 55.9% (95% CI 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 ( 9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariable analysis, using logistic regression, anosmia (adjusted OR 4.4 95% CI 2.21 - 8.74) and ocular pain (adjusted OR 1.95 95% CI 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) HCWs were hospitalized (seven were male) and 2 (1.6%) died. Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

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Microelimination of HCV in residual populations of coinfected HIV/HCV: real-life data from an hospital setting in Southern Italy

Cited by 2 publications

References 0 publications

High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

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