Microemulsion and interfacial properties of anionic/nonionic surfactant mixtures based on sulfonate surfactants: The influence of alcohol

Wu, Juan; Mei, Ping; Lai, Lu

doi:10.1016/j.molliq.2022.120814

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…According to research findings, co-surfactants are crucial components in SMEDDS formulations that boost target compound loading and enlarge the self-emulsification zone in phase diagrams 38 . A single surfactant rarely provides the fluid interfacial film, and microemulsion stability requires brief negative interfacial tension 39 . Co-surfactants usually reduce interface bending stress and give the interfacial layer enough elasticity/flexibility to generate microemulsions in various compositions.…”

Section: Resultsmentioning

confidence: 99%

Gynura procumbensLeaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

Shill,

Jalal,

Shuma

et al. 2024

Preprint

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Gynura procumbens, known as longevity spinach, is a plant traditionally used in tropical Asian countries for its anti-inflammatory, hepatoprotective, anti-hypertensive, anti-hyperglycemic, and anti-inflammatory properties. The current study aimed to enhance the hepatorenal protective activity of Gynura procumbens leaf extract (GLE) by developing a self-microemulsifying drug delivery system (SMEDDS). SMEDDS-GLE exhibited the formation of small micelles with a mean droplet size of 231 nm. This resulted in a significant enhancement in the dispersion of GLE in water, as evidenced by a dispersibility that was at least 4.8 times greater than that of GLE alone. In the rat model of hepatic injury induced by cisplatin (7.5 mg/kg, i.p.), the administration of SMEDDS-GLE (75 mg-GLE/kg, p.o.) significantly reduced liver damage, observed by histological examination and reduced levels of plasma biomarkers associated with hepatic injury. Furthermore, according to histological examination findings and plasma biomarkers assessment, SMEDDS-GLE enhanced nephroprotective benefits of GLE in the rat model of acute kidney injury. Based on these findings, a strategic application of the SMEDDS-based approach could be a viable choice to enhance GLE's nutraceutical properties.

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Section: Resultsmentioning

confidence: 99%

Gynura procumbensLeaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

Shill,

Jalal,

Shuma

et al. 2024

Preprint

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“…For microemulsion systems, DLS primarily measures the droplet size information of micelles within the microemulsion system, including the hydrodynamic diameter [ 86 ], Particle Dispersion Index (PDI) [ 87 ], relaxation time [ 68 ], etc. It is also used to investigate behaviors such as droplet diffusion and coalescence under different conditions [ 77 ], analyzing the impact of different times or temperatures on system stability.…”

Section: Microemulsion Characterization Techniquesmentioning

confidence: 99%

Advancements in Characterization Techniques for Microemulsions: From Molecular Insights to Macroscopic Phenomena

Li,

Qu,

Liu

et al. 2024

Molecules

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Microemulsions are thermodynamically stable, optically isotropic, transparent, or semi-transparent mixed solutions composed of two immiscible solvents stabilized by amphiphilic solutes. This comprehensive review explores state-of-the-art techniques for characterizing microemulsions, which are versatile solutions essential across various industries, such as pharmaceuticals, food, and petroleum. This article delves into spectroscopic methods, nuclear magnetic resonance, small-angle scattering, dynamic light scattering, conductometry, zeta potential analysis, cryo-electron microscopy, refractive index measurement, and differential scanning calorimetry, examining each technique’s strengths, limitations, and potential applications. Emphasizing the necessity of a multi-technique approach for a thorough understanding, it underscores the importance of integrating diverse analytical methods to unravel microemulsion structures from molecular to macroscopic scales. This synthesis provides a roadmap for researchers and practitioners, fostering advancements in microemulsion science and its wide-ranging industrial applications.

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“…In recent years, researchers have investigated the effects of the interfacial properties for different types of surfactants such as nonionic, anionic, cationic, and zwitterionic surfactants by using interfacial dilational rheology. [12][13][14][15] Aromatic side chained amphiphiles are surfactants that possess large, functionalized branches and exhibit good surface activity, solubility, and aggregation behavior. Gu et al 16 synthesized carboxylates and sulfonates with different aromatic side chains, and they noticed that the position of the aromatic side chain on the amphiphiles was critical in determining the stability and type of lyotropic liquid crystal phase.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of aromatic side chains on the dilational rheological properties of N-acyltaurate amphiphiles at water–decane interfaces

Zhu,

Xu,

Zhang

et al. 2024

Soft Matter

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Microemulsion and interfacial properties of anionic/nonionic surfactant mixtures based on sulfonate surfactants: The influence of alcohol

Cited by 8 publications

References 48 publications

Gynura procumbensLeaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

Gynura procumbensLeaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

Advancements in Characterization Techniques for Microemulsions: From Molecular Insights to Macroscopic Phenomena

The effect of aromatic side chains on the dilational rheological properties of N-acyltaurate amphiphiles at water–decane interfaces

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