Microemulsion and its application: An inside story

Mitra, Debolina

doi:10.1016/j.matpr.2023.01.149

Cited by 13 publications

(6 citation statements)

References 66 publications

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“…On the other hand, microemulsions’ droplet size is concentrated in the domain of nanoemulsions, restricting up to 100–200 nm, due to the presence of high concentrations of S/CoS mix reaching up to 70% of the total composition. The high thermodynamic stability and clear appearance of microemulsions promoted by the self-emulsification technique continue to draw attention in the area of drug delivery and beyond [ 81 , 82 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery.

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Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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“…Importantly, applications of microemulsions have witnessed enormous growth due primarily to the unusual structural aspects and subsequent properties of these interesting aggregates. The primary areas of applications in pharmaceutical industries are in sustained and improved delivery and bioavailability of various drugs and as carriers for biomolecules such as proteins and peptides. , Applications of microemulsions are widespread in oil and gas industries to reduce interfacial tension that traps residual oils and for surface cleaning. , Besides, they have been used extensively in consumer and industrial cleaning formulations; in food technology and preparation; , as novel compartmentalized chemical reaction media, especially in template-assisted nanomaterial syntheses; , to assist in polymerization and other reactions; and in effective active ingredient delivery …”

Section: Introductionmentioning

confidence: 99%

Formation of Ethanolamine-Mediated Surfactant-Free Microemulsions Using Hydrophobic Deep Eutectic Solvents

Anjali,

Pandey

2024

Langmuir

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Hydrophobic deep eutectic solvents (HDESs) are emerging as versatile, relatively benign, and inexpensive alternatives to conventional organic solvents in a diverse set of applications. In this context, the formation of microemulsions with HDES replacing the oil phase has become an area of active exploration. Because of recent reports on the undesirable toxicity of many common surfactants, efforts are under way to investigate the formation of surfactant-free microemulsions (SFMEs) using HDES as an oil phase. We present SFME formation using HDESs constituted of n-decanoic acid and five (5) structurally different terpenoids [thymol, l(−)-menthol, linalool, β-citronellol, and geraniol] at a 1:1 molar ratio as the oil phase and water as the hydrophilic phase. Ethanolamine (ETA) exhibited the best potential as a hydrotrope among several other similar small molecules. Results showed a drastic increase in water solubility within the HDESs in the presence of ETA. ETA exerted its hydrotropic action at different extent for each DES system via chemical interaction with the H-bond donor (HBD) constituent of the HDES. The optimum hydrotropic concentration (minimum hydrotrope and maximum water retention, X ETA OPT) assigned for each DES/ETA/water system and water loading are reported, and the trends are discussed in detail. Ternary phase diagrams are constructed using visual observation and the dye staining method. The area under the single- and multiple-phase regions (assigned in ternary phase diagrams) was estimated. “Pre-Ouzo” enforced by ETA was investigated using dynamic light scattering (DLS) of the DES/ETA/water systems at X ETA OPT. A systematic growth in nanoaggregates was observed with the subsequent addition of water in DES/ETA systems while continuously changing the existing microstructure. The presence of a core (oil)–shell (water)-like structure as indicated by the fluorescence response of Nile red in the “pre-Ouzo” region is speculated. We were able to prepare a homogeneous solution of [K3Fe(CN)6] salt in “pre-Ouzo” mixtures with no apparent deviation in the Beer–Lambert law.

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“…The traditional preparation of microemulsions with below 100 nm DS requires a large number of surfactants and co-surfactants up to with ca. 15% [6] , which brings out some obvious side effects, e.g., severe physiological stimulation and allergic reactions [7] . In order to reduce the use of surfactants and improve the compliance, high-energy technologies (high-pressure homogenization, ultrasound, etc.,) were attempted to prepare microemulsions.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsification of soybean oil using ultrasonic microreactor: Process optimization, scale-up and numbering-up in series

Zhu

Zhang

et al. 2023

Ultrasonics Sonochemistry

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Microemulsion and its application: An inside story

Cited by 13 publications

References 66 publications

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Formation of Ethanolamine-Mediated Surfactant-Free Microemulsions Using Hydrophobic Deep Eutectic Solvents

Nanoemulsification of soybean oil using ultrasonic microreactor: Process optimization, scale-up and numbering-up in series

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