Microemulsion-based media as novel drug delivery systems

Lawrence, M. Jayne; Rees, Gareth D.

doi:10.1016/j.addr.2012.09.018

Cited by 585 publications

(554 citation statements)

References 194 publications

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“…The stability of a ME depends on the interfacial interaction system established by the surfactant and co-surfactant between water and oil. So, the development of thermodynamically stable systems occurs by determining the appropriate ratio of surfactants (Lawrence and Rees 2012). Although the HLB is an empirical and representative value of the content of hydrophilic and lipophilic properties of the surfactant, it was shown to effectively allow the preparation of a large area of ME, an agreement with literature (Lin 1970;Wu et al, 2001;Zhang and Que 2008).…”

Section: Resultssupporting

confidence: 70%

“…The F1, F2, F4, F6, and F7 indicated average hydrodynamic diameter of 64.62; 49.73; 33.35; 104.55 and 122.18nm, respectively. Literature shows the diameters of the structures to be dependent on the surfactant ratio and oil phase of ME (Formariz et al, 2005), differently than nanoemulsions that also depend on the preparation process, specially on the type of mixing/blend (Ghosh et al, 2012). It was observed the formation of Nano scale structures with decreased hydrodynamic diameter when the surfactant proportion predominates over the oil phase (Aboofazeli et al, 2000;Tadros et al, 2004;Lawrence and Rees 2012). These results collaborate with the data of the systems developed, and indicate that the increase of Brazil nut oil concentration promoted a tendency to reduce the hydrodynamic diameter in specific proportions of aqueous phase (10 %).…”

Section: Resultsmentioning

confidence: 99%

“…ME have become a promising bioavailability enhancer. For that, immiscible liquids are stabilized by surfactants, reducing their surface tension, emulsifying, dispersing and solubilizing solutes, combining the active ingredient in one of the phases (Acharya and Hartley, 2012;Lawrence and Rees, 2012;Ribeiro et al, 2015). Its benefits include increased API solubility, minimized degradation processes such as thermal and photo degradation, gastric resistance, controlled release of active ingredient, reduction of therapeutic dosage and consequent side effects, improving the adherence to treatment which leads to a significant improvement of a known therapy (Kesarwani and Gupta, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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Brazil nut (Bertholletia excelsa H. B. K.) is one of the most valuable national Lecythidaceae from Brazil, collaborating with local economy. Besides being rich in nutrients, it has high content of unsaturated fatty acids, proteins and vitamins. On the other hand, levamisole (LMS) is a synthetic imidazothiazole derivative mostly used as agent in anthelmintic treatment; however it is reported to have issues in its oral bioavailability. Microemulsion (ME), immiscible liquids stabilized by surfactants, is a promising bioavailability enhancer nowadays by modifying the release of active ingredient at its site of action, reducing therapeutic dosage with consequent side effects, and increasing absorption of natural ingredients. So, the development of a stable ME containing Brazil nut oil to carry LMS can be a promising pharmaceutical form in this drug therapeutic efficiency behalf. For that, it was developed a stable oil-in-water ME which held pH, conductivity, and refractive index along the study, presenting satisfactory stability under long-term stress conditions. Its particle size is classified as nanostructure (33,35nm), and rheological parameters confirmed a Newtonian behavior, with constant viscosity. The Brazil nut oil ME can be an alternative as adjuvant in pharmaceutical forms and a promising upgrading tool to carry LMS, improving its therapy.

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Section: Resultssupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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“…At lower surfactant concentration and higher oil content, larger droplet size was observed. Contrary effect exhibited in C, D and E. The least size was obtained with 10% oil, 60% surfactant and 30% co-surfactant, however gastric irritation may occur at higher surfactant concentration (Lawrence, 2000). The size was found to be less than 150 nm, and then most consistent with oil: surfactant: co-surfactant of 90:6.66:3.33; 80:13.33:6.66 and 50:16.66:33.33.…”

mentioning

confidence: 76%

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Villar

Naveros

Campmany

et al. 2012

International Journal of Pharmaceutics

143

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Self nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the formulation variables, X1 (Cremophor® EL), X2 (Capmul® MCM -C8), and X3 (lemon essential oil). Systems were assessed for visual characteristics (emulsification efficacy), turbidity, droplet size, polydispersity index and drug release. Different pH media were also assayed for optimization. Following optimization, the values of formulation components (X1, X2, and X3) were 32. 43%, 29.73% and 21.62 %, respectively (16.22% of gemfibrozil). Transmission electron microscopy demonstrated spherical droplet morphology. SNEEDS release study was compared to commercial tablets. Optimized SNEDDS formulation of gemfibrozil showed a significant increase in dissolution rate compared to conventional tablets. Both formulations followed Weibull mathematical model release with a significant difference in td parameter in favour of the SNEDDS. Equally amodelistic parameters were calculated being the dissolution efficiency significantly higher for SNEDDS, confirming that the developed SNEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile. This paper provides an overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption. She is an expert in nanotechnology (colloids and nanoparticles) with a wide experience. She has extensive curriculum of published paper about this subject Jose Luis Arias Mediano Ph. D. Professor reseracher, Pharmacy and Pharmaceutical Technology , University of Granada jlarias@ugr.es He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer in specialized pharmaceutical journal. He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer of Pharmaceutical science journals. IJP AUTHOR CHECKLISTDear Author, It frequently happens that on receipt of an article for publication, we find that certain elements of the manuscript, or related information, is missing. This is regrettable of course since it means there will be a delay in processing the article while we obtain the missing details.In order to avoid such delays in the publication of your article, if accepted, could you please run through the list of items below and make sure you have completed the items. Overall Manuscript Electronic artwork format? ---------------------------------------------------TIFF

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“…Among other physical approaches such as nanosuspensions (Müller et al, 2001), crystallization techniques (Fages et al, 2004;Rasenack and Müller, 2002) and the use of solubilizers (e.g., surfactants (Lawrence and Rees, 2000;Pouton, 1997) and cyclodextrins (Brewster and Loftsson, 2007)), polymerbased solid dispersions has received a great deal of attention to overcome the hurdle of limited solubility (Vasconcelos et al, 2007). Amorphous solid dispersion of a drug in an inert water-soluble matrix (most often a polymer) ensure improved dissolution owing to three reasons: on the one hand higher solubility of the amorphous drug, on the other hand the wellsoluble hydrophilic carrier used, thirdly an increased surface area can be obtained depending on the preparation method (Nagy et al, 2012).…”

Section: Introductionmentioning

confidence: 99%