Microemulsion-based media as novel drug delivery systems

Lawrence, M. Jayne; Rees, Gareth D.

doi:10.1016/s0169-409x(00)00103-4

Cited by 1,573 publications

(616 citation statements)

References 198 publications

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“…The visual appearance of microemulsions does not change with time, inferring thermodynamic stability, a further distinguishing feature to other emulsions. These properties and features lead to applications of microemulsions as nanoreactors in chemical [1] and nanoparticle synthesis [2], as nanoparticle recovery vehicles [4], in soil remediation processes, enhanced oil recovery [5], pharmaceutical delivery [6], and engine oil and fuel additives [7].…”

Section: Introductionmentioning

confidence: 99%

Effects of small ionic amphiphilic additives on reverse microemulsion morphology

Hatzopoulos

James

Rogers

et al. 2014

Journal of Colloid and Interface Science

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Effects of small ionic amphiphilic additives on reverse microemulsion morphology Research Highlights Cylindrical morphologies of reverse microemulsions induced by small molecule hydrotropes.  Ellipsoidal droplets of high aspect ratio in reverse AOT microemulsions are induced by short chain alkanoate additives.  A cylinder to sphere transition in reverse AOT microemulsions is seen with increasing water content. . Microemulsion domain structures were investigated by small-angle neutron scattering (SANS), and these data were fitted by structural models to yield information on the shapes (spheres, ellipsoids or cylinders) and sizes of the nanodroplets. Effects of small ionic amphiphilic additives on reverse microemulsion morphology FindingsUnder the conditions of study hydrotrope chemical structure has a significant effect on microemulsion structure: sodium cyclohexanoate does not induce the formation of cylindrical/ellipsoidal nanodroplets, whereas the aromatic analogue sodium benzoate does. Furthermore, the short chain sodium hexanoate does not cause anisotropic microemulsions, but the more hydrophobic longer chain heptanoate and octanoate analogues do induce sphere-to-ellipsoid transitions. This study shows that underlying microemulsion structures can be tuned by hydrotropes, and that the strength of the effect can be identified with hydrotrope hydrophobicity in terms of the bulk aqueous phase cac.

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Section: Introductionmentioning

confidence: 99%

Effects of small ionic amphiphilic additives on reverse microemulsion morphology

Hatzopoulos

James

Rogers

et al. 2014

Journal of Colloid and Interface Science

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“…Organic-inorganic hybrid hollow silica nanospheres [5] and hollow mesoporous silica nanoworms [6] were synthesized using a chiral cationic low-molecular-weight amphiphile as template. The formation of O/W emulsion is reasonable because the P123 micelles with n-decane solubilized inside as swelling agent can transform to emulsion droplets while excess amount of n-decane is used in the synthesis of hexagonally ordered materials [23][24][25][26][27]. In the synthesis process in current work, the residual water-rich layer is initially turbid right after the removal of decane-rich layer at room temperature but becomes clear and stable while its temperature was increased to 40°C.…”

Section: Resultsmentioning

confidence: 88%

“…1. Then, we can know that these onion-like silica spheres, with some parallel mesoporous tubes along their edge, are related to initial patterns of the cocoon-like pouches containing the wall constructed by hexagonally ordered channels [22][23][24][25][26][27]. Under static condition without stirring, the aggregation of the onion-like silica spheres is absent or proceeds very slowly and thus the hexagonally ordered structure can not be built [22].…”

Section: Resultsmentioning

confidence: 99%

Hierarchical fabrication of silica cocoon with hexagonally ordered channel constructed wall via an emulsion-assisted process

zhang

Wang

et al. 2012

Microporous and Mesoporous Materials

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“…A literatura 18,[29][30][31][32] considera que um sistema disperso para ser considerado ME é necessário que o tamanho de suas gotículas da fase interna esteja entre 10 e 150 nm. Por isso, podemos estimar que o sistema estudado seja uma MEG, bem como podemos utilizá-la para realização dos estudos posteriores.…”

Section: Caracterização Físico-química Da Megunclassified

Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like

Silva¹,

Santana²,

Bedor³

et al. 2009

Quím. Nova

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Recebido em 25/3/08; aceito em 25/2/09; publicado na web em 3/7/09 IN VITRO RELEASE AND PERMEATION OF A DICLOFENAC DIETHYLAMINE FROM MICROEMULSION GEL-LIKE.The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudoternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher K p of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA K p 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel.Keywords: diclofenac diethylamine; in vitro release; microemulsion gel-like. INTRODUÇÃOA administração tópica é conhecida como via alternativa da administração oral de ativos medicamentosos e oferece muitas vantagens como a ausência de efeito de primeira passagem, o fato de ser indolor e a facilidade de aplicação. 1 Todavia, uma eficácia tópica só é obtida a partir de fármacos potentes com adequado grau de penetração na pele. 2 Isto tem levado a um crescente interesse pela utilização de promotores de permeação em formulações tópicas, assim como o uso de sistemas de liberação de fármacos com esta capacidade promotora de permeação. 3 As microemulsões (ME) são dispersões isotrópicas, transparentes, termodinamicamente estáveis, usualmente formadas por misturas de quatro componentes, água, óleo, tensoativo e cotensoativo. Apresentam grande potencial como sistemas de liberação e de direcionamento de fármacos, pelas propriedades de solubilizar fármacos hidrofílicos em meio lipofílico, lipofílicos em meio aquoso e anfifílicos na interface óleo/água. 4-10 Além disso, estes sistemas apresentam capacidade de se formarem espontaneamente, podendo existir sob várias formas estruturais (globular a/o e o/a, bicontínuas, cúbicas ou lamelares), 11,12 e atuam como promotores de permeação de vários fármacos, devido ao reduzido tamanho das gotículas formadas, assim como ao seu alto conteúdo de tensoativo, que desorganiza os lipídeos da pele. 5 O diclofenaco de dietilamônio (DDA) é um anti-inflamatório não esteroidal (AINEs) capaz de formar micelas e cristais líquidos liotrópicos em água. 13 Apresenta a capacidade de interagir com os fosfolipídeos da pele, contribuindo para aumentar a fluidez do mesmo no estrato córneo, fazendo com que os lipídios passem de uma forma cristalina ordenada para uma forma líquida desordenada, aumentando, portanto, a permeabilidade cutânea. 5,7 Além disso, o DDA apresenta metabolismo hepático, tempo de meia-vida curto, 14 não sofre metabolismo na pele, não induz tolerância e tem bom coeficiente de partição. 15 Com base nas colocações acima e na importância do tema, o objetivo do presente trabalho foi a obtenção e a caracterização de uma ME, na forma gel (MEG) contendo DDA, como sistema promotor de permeação do f...

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Microemulsion-based media as novel drug delivery systems

Cited by 1,573 publications

References 198 publications

Effects of small ionic amphiphilic additives on reverse microemulsion morphology

Effects of small ionic amphiphilic additives on reverse microemulsion morphology

Hierarchical fabrication of silica cocoon with hexagonally ordered channel constructed wall via an emulsion-assisted process

Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like

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