Microemulsion dynamics and reactions in microemulsions

López‐Quintela, M. Arturo; Tojo, C.; Blanco, M. Carmen; Rio, L. Garcı́a; Leis, Jaan

doi:10.1016/j.cocis.2004.05.029

Cited by 378 publications

(283 citation statements)

References 103 publications

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“…Collisions occur between the droplets and the most energetic of these cause transient droplet dimers to form, with accompanying exchange of interior content. 5 This enables the (near) stable nuclei to gain access to more molecules and grow until they become larger than the droplets and so are no if, e.g. it was sufficiently stabilized by the surrounding solvent.…”

Section: Manuscript Textmentioning

confidence: 99%

Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology

Nicholson

Chen

Mendis

et al. 2011

Crystal Growth & Design

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. (2011) 'Stable polymorphs crystallized directly under thermodynamic control in three-dimensional nanocon nement : a generic methodology.', Crystal growth design., 11 (2). pp. 363-366. Further information on publisher's website:https://doi.org/10.1021/cg101200fPublisher's copyright statement:This document is the Accepted Manuscript version of a Published Work that appeared in nal form in Crystal growth design, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the nal edited and published work see https://doi.org/10.1021/cg101200fAdditional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractThermodynamic control of crystallization has been achieved to produce stable polymorphs directly by using 3D nano-confinement in microemulsions. The theoretical basis for thermodynamic control of crystallization using 3D nano-confinement is outlined. Our approach leap-frogs the usual metastable polymorph pathway because crystallization becomes governed by the ability to form stable nuclei, rather than critical nuclei. The generality of this approach is demonstrated by crystallizing the stable polymorph of three 'problem' compounds from microemulsions under conditions yielding metastable forms in bulk solution. The polymorphic compounds are mefenamic acid (2-[(2,3-(dimethylphenyl)amino] benzoic acid), glycine (aminoethanoic acid) and the highly polymorphic 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophenecarbonitrile, commonly known as ROY because of its red, orange and yellow polymorphs. Application of this methodology should prevent another Ritonavir-type disaster, whereby a marketed drug transforms into a more stable form, reducing its bioavailability and effectiveness. The lowest energy nuclei selectively grow in our approach. Consequently this also provides a generic method for producing higher crystallinity materials, which may prove beneficial for crystallizing proteins and inorganic nanocrystals.Statement of urgency and brief summary of significant findings. We believe the paper fulfills the requirements of urgency for a Communication because it details for the first time a generic method to obtain thermodynamic control of crystallization. This enables stable polymorphs to be crystallized directly, to prevent another Ritonavir-type disaster. The methodology used selectively grows the lowest energy crystal nuclei, so it can also produce materials with higher crystallinity, which may prove of use for a wide range of crystalline materials, including potential...

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Section: Manuscript Textmentioning

confidence: 99%

Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology

Nicholson

Chen

Mendis

et al. 2011

Crystal Growth & Design

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“…By microemulsion dynamics, we note the fact that each of water nanodomain is not static one, but in continuous movement and collision with each other [24]. In each collision, material interchange can take place.…”

Section: Introductionmentioning

confidence: 97%

“…The microemulsion, especially water-in-oil (W/O), which consists of water nanodroplets dispersed in the bulk oil phase and is stabilized in spherical reverse micelles, can be considered as "nanoreactor" for the synthesis of nanoparticles. When two water nanodroplets collide, which are driven by the Brownian motion, they fuse and interchange reactants [24]. Since the chemical reaction is limited to the nuclear interior in water, the microemulsion method has obvious advantages to manipulate the particles size and shape, also to regulate narrow particle size distribution by controlling the amount of the mixture oil/water/surfactant [25,26].…”

Section: Introductionmentioning

confidence: 99%

Surfactant effects on the microstructures of Fe3O4 nanoparticles synthesized by microemulsion method

Wang

Yin

et al. 2013

Colloids and Surfaces A: Physicochemical and Engineering Aspect

108

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“…The visual appearance of microemulsions does not change with time, inferring thermodynamic stability, a further distinguishing feature to other emulsions. These properties and features lead to applications of microemulsions as nanoreactors in chemical [1] and nanoparticle synthesis [2], as nanoparticle recovery vehicles [4], in soil remediation processes, enhanced oil recovery [5], pharmaceutical delivery [6], and engine oil and fuel additives [7].…”

Section: Introductionmentioning

confidence: 99%

Effects of small ionic amphiphilic additives on reverse microemulsion morphology

Hatzopoulos

James

Rogers

et al. 2014

Journal of Colloid and Interface Science

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Effects of small ionic amphiphilic additives on reverse microemulsion morphology Research Highlights Cylindrical morphologies of reverse microemulsions induced by small molecule hydrotropes.  Ellipsoidal droplets of high aspect ratio in reverse AOT microemulsions are induced by short chain alkanoate additives.  A cylinder to sphere transition in reverse AOT microemulsions is seen with increasing water content. . Microemulsion domain structures were investigated by small-angle neutron scattering (SANS), and these data were fitted by structural models to yield information on the shapes (spheres, ellipsoids or cylinders) and sizes of the nanodroplets. Effects of small ionic amphiphilic additives on reverse microemulsion morphology FindingsUnder the conditions of study hydrotrope chemical structure has a significant effect on microemulsion structure: sodium cyclohexanoate does not induce the formation of cylindrical/ellipsoidal nanodroplets, whereas the aromatic analogue sodium benzoate does. Furthermore, the short chain sodium hexanoate does not cause anisotropic microemulsions, but the more hydrophobic longer chain heptanoate and octanoate analogues do induce sphere-to-ellipsoid transitions. This study shows that underlying microemulsion structures can be tuned by hydrotropes, and that the strength of the effect can be identified with hydrotrope hydrophobicity in terms of the bulk aqueous phase cac.

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Microemulsion dynamics and reactions in microemulsions

Cited by 378 publications

References 103 publications

Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology

Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology

Surfactant effects on the microstructures of Fe3O4 nanoparticles synthesized by microemulsion method

Effects of small ionic amphiphilic additives on reverse microemulsion morphology

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