Microemulsions as nano-reactors for the solubilization, separation, purification and encapsulation of bioactive compounds

Jalali-Jivan, Mehdi; Garavand, Farhad; Jafari, Seid Mahdi

doi:10.1016/j.cis.2020.102227

Cited by 50 publications

(14 citation statements)

References 103 publications

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“…Due to the high cost of equipment and the use of high volume of toxic solvents in the mentioned methods, the separation of organic compounds, such as amino acids, organic acids, some vitamins, dyes, etc., from the biological sources using emulsion liquid membrane technique (ELM) has attracted a lot of attention in the recent years ( 12 ). Indeed, the isolation of organic compounds by ELM technique has many advantages, including high solvent transfer flux, high specificity, minimal use of toxic organic solvents and their recyclability, and the replacement of conventional organic solvents ( 13 ). The liquid membrane system consists of a diluent, a surfactant to stabilize the emulsion, and a carrier to separate the solutes by chemical reaction.…”

Section: Introductionmentioning

confidence: 99%

Tuning the Physicochemical, Structural, and Antimicrobial Attributes of Whey-Based Poly (L-Lactic Acid) (PLLA) Films by Chitosan Nanoparticles

et al. 2022

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Recently, the research and innovation to produce raw materials from microbial processes has gained much attention due to their economic and environmental impacts. Lactic acid is a very important microbial product due to its wide application in the food, pharmaceutical, cosmetic, and chemical industries. In the current study, poly (L-lactic acid) (PLLA) was produced by the ring opening polymerization (ROP) technique of L-lactic acid recovered from whey fermentation, and was used for the production of nanocomposites films reinforced with chitosan nanoparticles (CNPs) (average diameter ca. 100–200 nm). Three different CNPs concentrations, namely 1, 3, and 5% w/w, were tested, and their influence on the physical, mechanical, thermal, antibacterial and structural attributes of PLLA film was assessed. The results showed that the addition of CNPs up to 3% caused a significant improvement in water vapor permeability, appearance, tensile strength and elongation at break. The antibacterial properties of nanocomposites followed a dose-depended pattern as a result of CNPs addition. Therefore, the best inhibitory effects on Escherichia coli and Staphylococcus aureus was made by the addition of 5% of CNPs and lower dosages slightly affected the growth of pathogens or didn't cause any inhibitory effects (in 1% of CNPs). It can be concluded that the incorporation of CNPs into the PLLA matrix allows to improve the structural, thermal, physical, mechanical and antibacterial properties of the polymer, generating promising systems for food packaging and biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Tuning the Physicochemical, Structural, and Antimicrobial Attributes of Whey-Based Poly (L-Lactic Acid) (PLLA) Films by Chitosan Nanoparticles

et al. 2022

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“…Surface active agents, or surfactants, are a special kind of material that can reduce interfacial tension, form micelles, colloid systems in solutions, that create a different microenvironment in a bulk solution when dissolved in water or some other solvents. Surfactants from an earlier age are being widely utilized in domestic as well as industrial purposes [ 19 , 20 , 21 , 22 , 23 ]. Nowadays surfactants influence the majority of phases of our daily life, either directly in household detergents and personal care products or indirectly in the production and processing of the materials which surround us.…”

Section: Introductionmentioning

confidence: 99%

“…The low polarity environment is created by the hydrophobic core while high charge concentration (ionic surfactants) or high polarity (nonionic surfactants) regions are created by the head groups. When an amphiphilic drug is incorporated into the micelle of surfactant via self-association or by other means [ 23 ], drug physicochemical properties (reaction rates, reaction mechanism, degree of ionization, etc.) may be affected.…”

Section: Introductionmentioning

confidence: 99%

Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants

Azum

Rub

Khan

et al. 2022

Gels

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In this approach, tensiometry and UV-visible techniques are used to determine the effect of cationic gemini and conventional surfactants on tetracaine hydrochloride (TCH), an anesthetic drug. We have estimated micellar, interfacial, and energetic constraints. To gain a deep understanding of their mixed association behavior, the outputs were examined using different theoretical models. The critical micelle concentration for single and mixed amphiphiles was estimated. The cmc values of mixed amphiphiles were found between the individual amphiphiles due to strong attractive interaction (synergism) between the components after mixing. The non-ideal behavior of mixtures was confirmed by the larger values of ideal cmc than the experimental cmc values. The negative values of interaction parameter (β) and values of activity coefficients less than unity indicate strong synergistic interaction between drug and surfactant. The stability of the mixed systems is demonstrated by the negative Gibbs free energy of micellization and excess free energy of micellization. In contrast to a single chain surfactant, a double chain surfactant (gemini) exhibits better interactions with the drug. Spectral measurements (UV-visible spectra) were used to monitor the binding of the drug with surfactant (conventional as well as gemini). Studying these mixed aggregates could help to optimize their compositions and find synergistic properties between TCH monomers and surfactants.

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“…To help achieve the production of healthier food, numerous techniques and methodologies have been developed within the last couple decades following the nutrient fortification (Akhtar et al, 2011;Shilpashree et al, 2015;Zhu et al, 2020) or encapsulation path when components sensitive to processing (i.e., vitamins, antioxidants, enzymes, probiotics) are incorporated (Ye et al, 2018;Maurya et al, 2020;Castro Coelho et al, 2021). For the encapsulation of bioactive ingredients, several technologies have been proposed including nano/microemulsification, spray drying, lyophilization, electro-spinning/ spraying (Ray et al, 2016;Jalali-Jivan et al, 2020;Moreira et al, 2020). However, micro-emulsions are considered more advantageous than nano-emulsions since they are transparent and therefore do not affect the appearance of food products nor they require expensive equipment or ingredients for their formation McClements, 2018).…”

Section: Introductionmentioning

confidence: 99%

Fortification of chocolate usingMoringa oleiferaextract encapsulated in microemulsions

Kaltsa

Alibade

Batra

et al. 2021

OCL

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The aim of the present study was to evaluate the physical and antioxidant properties of microemulsions containing Moringa oleifera leaf extract (MLE) produced by the means of a deep eutectic solvent. Selected microemulsions containing MLE were incorporated in chocolate products to enrich them. Their color properties including CIE L*, a*, b* parameters and whitening index (WI) along with DPPH radical scavenging activity were assessed during a period of 8 months. The antioxidant activity of microemulsions depended on the oil phase used, while it was unaffected by the concentration of MLE. Samples prepared with soybean oil as oil phase containing MLE presented the highest radical inhibition percentage (I% = 26.8–27.8%). Coconut microemulsions were finally incorporated at 2 and 4% w/w concentration into chocolate products, as coconut oil is a known cocoa butter substitute. Although the incorporation of MLE microemulsions did not affect the color properties of most of the chocolates, enriched products did not exhibit superior antioxidant activity compared to control samples.

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Microemulsions as nano-reactors for the solubilization, separation, purification and encapsulation of bioactive compounds

Cited by 50 publications

References 103 publications

Tuning the Physicochemical, Structural, and Antimicrobial Attributes of Whey-Based Poly (L-Lactic Acid) (PLLA) Films by Chitosan Nanoparticles

Tuning the Physicochemical, Structural, and Antimicrobial Attributes of Whey-Based Poly (L-Lactic Acid) (PLLA) Films by Chitosan Nanoparticles

Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants

Fortification of chocolate usingMoringa oleiferaextract encapsulated in microemulsions

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