Microemulsions as nanoreactors for synthesis of biopolymer nanoparticles

Asgari, Sara; Saberi, Amir Hossein; McClements, David Julian; Lin, Mengshi

doi:10.1016/j.tifs.2019.02.008

Cited by 64 publications

(26 citation statements)

References 86 publications

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“…In this approach, microemulsion droplets act as nanocontainers or nanotemplates for particle synthesis. It has been mentioned that low viscosity and Newtonian character of microemulsions, as well as their ability to dissolve various reaction substrates are useful properties for applying these systems as reaction media for nanoparticles synthesis [ 71 ]. Additionally, large interfacial area present in these systems can be advantageous for increasing the rate of catalytic processes, even though their complexity and possible interaction with reagents can be challenging [ 72 ].…”

Section: Microemulsions: Structure Properties and Applicationsmentioning

confidence: 99%

Microemulsion-Based Media in Nose-to-Brain Drug Delivery

et al. 2021

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Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered intranasally can be delivered directly to the central nervous system. The most important advantage of this approach is the ability to avoid the blood–brain barrier surrounding the brain and blocking the entry of exogenous substances to the central nervous system. Moreover, selective brain targeting could possibly avoid peripheral side effects of pharmacotherapy. The challenges associated with nose-to-brain drug delivery are mostly due to the small volume of the nasal cavity and insufficient drug absorption from nasal mucosa. These issues could be minimized by using a properly designed drug carrier. Microemulsions as potential drug delivery systems offer good solubilizing properties and the ability to enhance drug permeation through biological membranes. The aim of this review is to summarize the current status of the research focused on microemulsion-based systems for nose-to-brain delivery with special attention to the most extensively investigated neurological and psychiatric conditions, such as neurodegenerative diseases, epilepsy, and schizophrenia.

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Section: Microemulsions: Structure Properties and Applicationsmentioning

confidence: 99%

Microemulsion-Based Media in Nose-to-Brain Drug Delivery

et al. 2021

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“…according to the scientist stability of nanoemulsion can be observed with the help of PIT method and reported that after the phase inversion takes place heating, cooling final temperature is reported which shows maximum influence on the distribution of size of the particles; also they observed that sufficient temperature for the storage which is purely based on surfactants these nanoemulsion are more stable form with very smaller sized particle having lesser polydispersity indices hence emulsion which is stored at standard temperature keep their small particle size and maximum stability 30 . All studies related to the influence of various salts such as inorganic on PIT, electrophoretic properties with long-time stability they found that by salting out of salt process in aqueous medium nanoemulsion having emulsifier with more PIT could be prepared easily which gives an optimal temperature by lowering of the PIT methods and suggested that for the instability of nanoemulsion Ostwald ripening is the main cause 31 .…”

Section: Stability Of Nanoemulsionmentioning

confidence: 99%

Untitled

2020

IJPSR

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Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the result of programmed senescence and prolonged environmental injury to the skin. The aim of this review article is to provide information regarding the control of skin aging by the nanoemulsion drug delivery system. Novel carrier systems have a lot of advantages when compared to conventional formulations. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, Retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated as nanosized carriers such as vesicular systems, Therefore, nanocarrier such as liposomes, noisome, microemulsions and nanoparticles have been widely investigated as delivery systems for antioxidants to improve their beneficial effects in the treatment of skin aging. In this review, an overview of cosmetic, product-oriented solutions for skin aging is given and different approaches to combat aging are summarized. This review discusses the role of oxidative events of tissue degeneration and aging in general, and for the skin in particular. The mechanisms involved in intrinsic and extrinsic (photo-) aging are described. To prevent or treat skin aging, topical supplementation with antioxidants is regarded as one of the most promising strategies. Overall review says that antioxidants are most commonly used in anti-aging cosmetic products will be reviewed along with the nanocarrier designed to improve their safety and effectiveness. INTRODUCTION: Nanoemulsion is a type of emulsion which is very fine and metastable in nature, the size of the droplets is smaller than the 100 nanometres. Based on the process used for the preparation of nanoemulsion their structure is identified.

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“…It is also a very important component in drug delivery systems [ 9 ] and the delivery of vaccines [ 18 ]. Due to their functional groups, chitosan and its derivatives can be used as a matrix for gels [ 45 , 46 , 47 , 48 ], emulsions [ 49 ], nanofibers [ 50 ], microparticles [ 51 ], nanoparticles [ 52 , 53 ], and other formulations.…”

Section: Introductionmentioning

confidence: 99%

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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Microemulsions as nanoreactors for synthesis of biopolymer nanoparticles

Cited by 64 publications

References 86 publications

Microemulsion-Based Media in Nose-to-Brain Drug Delivery

Microemulsion-Based Media in Nose-to-Brain Drug Delivery

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New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

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