Microemulsions as transdermal drug delivery systems for nonsteroidal anti-inflammatory drugs (NSAIDs): a literature review

Benbow, Tarique; Campbell, Jacqueline

doi:10.1080/03639045.2019.1680996

Cited by 33 publications

(18 citation statements)

References 66 publications

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“…It is also optically clear and macroscopically homogenous (Froelich et al., 2017 ). Furthermore, considerable energy input is not required for production, thus preparation is simple to produce and scale up, making it cost-effective (Benbow & Campbell, 2019 ). ME is made up of oil, aqueous phase, and the surfactant (a combination of surfactant and co-surfactant) (Benbow & Campbell, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, considerable energy input is not required for production, thus preparation is simple to produce and scale up, making it cost-effective (Benbow & Campbell, 2019 ). ME is made up of oil, aqueous phase, and the surfactant (a combination of surfactant and co-surfactant) (Benbow & Campbell, 2019 ). It can solubilize weakly water-soluble drugs and enhance penetration of the drugs through the skin, hence increase their bioavailability (Farghaly et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro , in vivo evaluation, and dermatokinetic studies

et al. 2021

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Crotamiton (CRT) is a commonly approved drug prescribed for the scabies treatment in many countries across the globe. However, poor aqueous solubility and low bioavailability, and side effects restrict its use. To avoid such issues, an appropriate carrier system is necessary which can address the aforementioned challenges for attaining enhanced biopharmaceutical attributes. The current study intends to provide a detailed account on the development and evaluation of CRT-loaded microemulsion (ME) hydrogel formulation containing tea tree oil (TTO) for improved drug delivery for scabies treatment in a safe and effective manner. Pseudo-ternary phase diagrams were constructed with TTO as the oily phase, and Cremophor ® EL was used as the surfactant in a mass ratio 2:1 with co-surfactants (mixture of phospholipid 90G and Transcutol ® P), and aqueous solution as the external phase. The optimized drug-loaded ME formulation was evaluated for skin penetration, retention, compliance, and dermatokinetics. The nonirritant behavior of the formulation was revealed by skin histopathology, which showed no changes in normal skin histology. In comparison to the conventional product, dermatokinetic experiments revealed that CRT has greater penetration and distribution in the epidermis of the mice skin. The findings imply that the proposed lipid-based ME hydrogel can aid in the resolution of CRT issues by providing a better and safer delivery option to epidermis and deeper epidermis in substantial quantities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro , in vivo evaluation, and dermatokinetic studies

et al. 2021

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“…Olfen ® (DNa) contains only isopropyl alcohol, while Voltaren ® Emulgel ® (DEA) includes isopropyl alcohol and propylene glycol as permeation enhancers. These components in vivo can diffuse to the skin surface and increase the permeation of drugs, either by disrupting the lipid structure of the stratum corneum or by increasing the solubility of the drug in the skin (i.e., increasing the partition coefficient of the drug between the skin and the vehicle) [ 45 ]. The study of Haltner-Ukomadu et al [ 40 ] revealed opposite results to ours.…”

Section: Resultsmentioning

confidence: 99%

Optimization and Evaluation of the In Vitro Permeation Parameters of Topical Products with Non-Steroidal Anti-Inflammatory Drugs through Strat-M® Membrane

et al. 2021

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Pharmaceutical products containing non-steroidal anti-inflammatory drugs (NSAIDs) are among the most prescribed topical formulations used for analgesic and antirheumatic properties. These drugs must overcome the skin barrier to cause a therapeutic effect. Human skin has been widely used as a model to study in vitro drug diffusion and permeation, however, it suffers from many limitations. Therefore, to perform in vitro permeation test (IVPT), we used a Strat-M® membrane with diffusion characteristics well-correlated to human skin. This study’s objective was to optimize the IVPT conditions using Plackett–Burman experimental design for bio-predictive evaluation of the in vitro permeation rates of five non-steroidal anti-inflammatory drugs (diclofenac, etofenamate, ibuprofen, ketoprofen, naproxen) across Strat-M® membrane from commercial topical formulations. The Plackett–Burman factorial design was used to screen the effect of seven factors in eight runs with one additional center point. This tool allowed us to set the sensitive and discriminative IVPT final conditions that can appropriately characterize the NSAIDs formulations. The permeation rate of etofenamate (ETF) across the Strat-M® membrane was 1.7–14.8 times faster than other NSAIDs from selected semisolids but 1.6 times slower than the ETF spray formulation.

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“…Microemulsion formulations are one of the most promising delivery system for topical administration NSAIDs [8]. They are thermodynamically stable colloidal nanocarriers formulated using isotropic mixture of oil, surfactant, co-surfactant and drug molecules [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Saribey¹,

Kahraman²,

Erdal³

et al. 2021

jrp

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The aim of this work was to develop colloidal nanocarriers for skin delivery of etodolac (ETD), which is a non-steroidal anti-inflammatory drug orally used for the management of acute pain and inflammation, but leads to unfavourable effects on the stomach. The oleic acid and blend of Labrasol/Trancutol P were used as oil phase and surfactant/co-surfactant mixture in the microemulsion formulations, respectively. ETD loaded microemulsions selecting the microemulsion region of pseudo-ternary phase diagrams were prepared, and then the microemulsions were characterised to confirm formation of oil in water microemulsions via optical isotropy, refractive index, droplet size, electrical conductivity, rheological behaviour and morphological analysis. In vitro permeation of ETD through porcine skin was evaluated using Franz diffusion cells for stable ETD loaded microemulsions. ATR-FTIR spectroscopy analysis was performed to elucidate interaction between the microemulsion components and stratum corneum structure on the molecular level. Confocal laser scanning microscopy analysis was further carried out to visualize skin penetration enhancement effect of the microemulsion formulation consisting of a model lipophilic fluorescent marker, Nile Red. The results indicated that the developed microemulsion formulation consisting of oleic acid, Labrasol, Transcutol P and water offer a potential approach to enhance skin delivery of ETD for topical treatment of inflammatory diseases.

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Microemulsions as transdermal drug delivery systems for nonsteroidal anti-inflammatory drugs (NSAIDs): a literature review

Cited by 33 publications

References 66 publications

Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro , in vivo evaluation, and dermatokinetic studies

Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro , in vivo evaluation, and dermatokinetic studies

Optimization and Evaluation of the In Vitro Permeation Parameters of Topical Products with Non-Steroidal Anti-Inflammatory Drugs through Strat-M® Membrane

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

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