Microencapsulated Liposomes in Controlled Drug Delivery: Strategies to Modulate Drug Release and Eliminate the Burst Effect

Dhoot, Nikhil O.; Wheatley, Margaret A.

doi:10.1002/jps.19104

Cited by 95 publications

(57 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore the formulation containing 10% trehalose and 0.2% leucine was selected. Although some levels of BSA leakage were found (Table 2), the entrapped efficiency was higher than previous studies (Dhoot and Wheatley, 2003).…”

Section: Liposomal Formulation Selection and Optimizationcontrasting

confidence: 45%

“…Both mechanisms are likely to contribute. Polymer coating can disrupt the trehalose liposome interaction but does not itself offer a specific protective effect thus allowing the liposomes to aggregate/fuse during drying and rehydration (Takeuchi et al 1998); or even for the polymers to become inserted into the liposomal lipid bilayers during rehydration, changing the membrane fluidity and leading to the leakage of entrapped solutes (Dhoot and Wheatley, 2003). As alginate did not cause size increase to the same extent as the other polymers, it is suggested that chitosan and TMC lead to vesicular aggregation through electrostatic interaction and disruption of the interaction between trehalose and the head groups of the phospholipids that is necessary for stabilization.…”

Section: Characterization Of Spray-dried Liposomesmentioning

confidence: 99%

See 1 more Smart Citation

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

Chen

Sabatino

Albertini

et al. 2013

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Liposomal Formulation Selection and Optimizationcontrasting

confidence: 45%

Section: Characterization Of Spray-dried Liposomesmentioning

confidence: 99%

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

Chen

Sabatino

Albertini

et al. 2013

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…The cumulative amount of BSA released over the time period was calculated using the following Eq. (3) [27,28]:…”

Section: Protein Release Studymentioning

confidence: 99%

Protein release kinetics for core–shell hybrid nanoparticles based on the layer-by-layer assembly of alginate and chitosan on liposomes

2008

View full text Add to dashboard Cite

“…[1][2][3][4][5] Considering that the primary route of liposome uptake in cells is through relatively low pH endosomes, pH-sensitive liposomes may be a favorable approach. [6][7][8] It has been reported that pH-sensitive vesicles with polymers immobilized on their surfaces can effectively mediate this type of release and fusion.…”

Section: Introductionmentioning

confidence: 99%

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Lu¹,

Wang²,

Ma³

et al. 2012

IJN

View full text Add to dashboard Cite

Background: Liposomes containing pH-sensitive polymers are promising candidates for the treatment of tumors and localized infection. This study aimed to identify parameters influencing the extent of contents release from poly(ethylacrylic acid) (PEAA) vesicles, focusing on the effects of polymer size, lipid composition, vesicle surface charge, and temperature. Methods: Anchored lipid pH-sensitive PEAA was synthesized using PEAA with a molecular weight of 8.4 kDa. PEAA vesicles were prepared by insertion of the lipid-anchored PEAA into preformed large unilamellar vesicles. The preformed liposomes were manipulated by varying the phosphocholine and cholesterol content, and by adding negative or positive charges to the liposomes. A calcein release assay was used to evaluate the effects of polymer size, liposome composition, surface charge, and temperature on liposomal permeability. Results: The release efficiency of the calcein-entrapped vesicles was found to be dependent on the PEAA polymer size. PEAA vesicles containing a phosphatidylcholine to cholesterol ratio of 60:40 (mol/mol) released more than 80% of their calcein content when the molecular weight of PEAA was larger than 8.4 kDa. Therefore, the same-sized polymer of 8.4 kDa was used for the rest of study. The calcein release potential was found to decrease as the percentage of cholesterol increased and with an increase in the phosphocholine acyl chain length (DMPC . DPPC . DSPC). Negatively charged and neutral vesicles released similar amounts of calcein, whereas positively charged liposomes released a significant amount of their contents. pH-sensitive release was dependent on temperature. Dramatic content release was observed at higher temperatures. Conclusion:The observed synergistic effect of pH and temperature on release of the contents of PEAA vesicles suggests that this pH-sensitive liposome might be a good candidate for intracellular drug delivery in the treatment of tumors or localized infection.

show abstract

Microencapsulated Liposomes in Controlled Drug Delivery: Strategies to Modulate Drug Release and Eliminate the Burst Effect

Cited by 95 publications

References 27 publications

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

Protein release kinetics for core–shell hybrid nanoparticles based on the layer-by-layer assembly of alginate and chitosan on liposomes

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Contact Info

Product

Resources

About