Microencapsulation of Cannabidiol in Liposomes as Coating for Cellulose for Potential Advanced Sanitary Material

Abstract

The microencapsulation of the cannabidiol and its integration into the tampon can eliminate vaginal inflammation, which at the same time lead to relaxation of the abdominal muscles. The tampon, which contains the active substance cannabidiol (CBD), was developed as an advanced fibrous composite for sanitary application. The active substances were microencapsulated, and, as a carrier, liposomes micro/nano capsules were used. The CBD liposome formulation was analyzed by particle size, polydispersity index, zeta potential, and encapsulation efficiency. Particle size of the CBD liposome liquid formulation was increased by 19%, compared to the liposome liquid formulation and the encapsulation efficiency of CBD in liposome particles, which was 90%. The CBD liposome formulation was applied to cellulose material. The composition of the fibrous composite material was evaluated by Fourier transform infrared spectroscopy, the fiber morphology was analyzed by scanning electron spectroscopy, while the bioactive properties were assessed by antioxidant efficiency, antimicrobial properties, and desorption kinetics. CBD liposome functionalized tampons have both antioxidant and antimicrobial properties. Antimicrobial properties were more pronounced against Gram-positive bacteria. The desorption kinetics of the CBD liposome immobilized on the surface of the composite material was studied using antioxidant activity in the desorption bath. The prepared CBD liposome functionalized tampon additionally shows higher biodegradability compared to references. This high-quality, biodegradable sanitary material based on microencapsulated CBD components as a functional coating provides a platform for many different applications besides medical textiles, also for packaging, pharmaceuticals, paper and wood-based materials, etc.

Characterization of CBD oils, seized on the Belgian market, using infrared spectroscopy: Matrix identification and CBD determination, a proof of concept

“…The loadings on PC1 and PC3 are almost identical, yet the loading of the carbonyl (C=O) band at 1744 cm −1 is very high on PC1 (Figure 9). 44 For the NIR spectra, lipids are shown at 5780 cm −1 , 5681 cm −1 , 4300 cm −1 , and 4255 cm −1 while aromatic hydrocarbons present in cannabinoids, like CBD, are typically present at 6000 cm −1 45 . Figure 10 represents the plot of loadings according to PC3 showing the spectral regions of lipids (C=O bands), and Figure 11 shows the plot of loadings according to PC1, which may be related to the CBD signal.…”

Chitosan-based films with cannabis oil as a base material for wound dressing application

“…It can be seen that the films containing cannabis oil exhibited a higher degradation rate as compared to pure chitosan. As the concentration of oil in the films increased, the degradation of the samples increased, which may be due to the presence of partially biodegradable cannabidiol but also due to the more hydrophilic properties and more accessible access of water to the film components 73 .…”

Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use

“…Volmajer Valh et al encapsulated CBD in liposomes to evaluate their potential sanitary utility by coating different viscous surfaces with CBD liposomes outlining both antimicrobial (on Gram + bacteria) and antioxidant effects. The product was developed as a biodegradable hygiene product to overcome menstrual symptoms [94].…”

“…Another attempt at liposome development was conducted by encapsulating the hemp extract in order to highlight the use of liposomal hemp in the treatment of cachexia in rats, showing good results since two out of seven mice showed improved body weight Volmajer Valh et al encapsulated CBD in liposomes to evaluate their potential sanitary utility by coating different viscous surfaces with CBD liposomes outlining both antimi-crobial (on Gram + bacteria) and antioxidant effects. The product was developed as a biodegradable hygiene product to overcome menstrual symptoms [94].…”