Microencapsulation par évaporation de solvant

André-Abrant, Anne; Taverdet, Jean‐Louis; Jacques, Jean

doi:10.1016/s0014-3057(00)00197-x

Cited by 25 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The comparison of drug effective diffusivities (D e ) allowed a valid discrimination between the different formulations prepared with various PLGA ratios by the two methods since it includes the effect induced by the PLGA film surrounding MS on the indomethacin diffusivity from the complex matrix (Table I). A similar diffusion governed release of ethylbenzoate-loaded ethylcellulose-MS over reduced time periods had been demonstrated by another group (Andre´-Arbant et al 2001).…”

Section: Release Studiessupporting

confidence: 78%

Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy

Madani¹,

Chaumeil²

2008

Journal of Microencapsulation

View full text Add to dashboard Cite

Indomethacin-loaded dietheylaminoethyl trisacryl Õ microspheres (DEAE-MS), originally designed for therapeutic embolization, were encapsulated using two methods: coacervation and solvent evaporation/extraction. This encapsulation was achieved using a biocompatible polymer, the PLGA 50 : 50, and aimed to control the release of the anti-inflammatory non-steroidal drug (AINSD) in the occluded vessel. PLGA degradation study showed that it had an erosion half-life of $35 days. Scanning electron microscopy (SEM) photographs showed that microcapsules (MC) prepared by coacervation had a wrinkled surface while those prepared using solvent-removal process showed non-porous, smooth surface, those of originally DEAE-MS showed a macroporous, rough surface. The mean diameters were 61 mm for naked DEAE-MS vs. 71 mm and 65 mm for MC prepared by coacervation and solvent evaporation/extraction method, respectively. In vitro release study of indomethacin adsorbed onto MS indicated that drug release from MC was controlled by a diffusion process. Indomethacin diffusivity from MC was much lower than its free diffusivity from MS (mean 14.5 and 10.5 times lower for formulations prepared by coacervation and solvent evaporation/extraction method, respectively). This indicates that efficient indomethacin concentrations could be maintained over much longer time-periods in the embolized region, which is assumed to be beneficial in inhibiting normally occurring inflammatory reaction and the subsequent revascularization; responsible for treatment failure when definitive occlusion is required.

show abstract

Section: Release Studiessupporting

confidence: 78%

Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy

Madani¹,

Chaumeil²

2008

Journal of Microencapsulation

View full text Add to dashboard Cite

show abstract

“…Therefore, by increasing the total quantity of drug, the percentage of drug encapsulated is increased. [17] In this study, the interaction between the ratio of osthole to PLGA and the volume ratio of o=w was not statistically significant (P > 0.05). Figure 3 shows the effect of the ratio of osthole to PLGA and the emulsification stirring speed on the encapsulation efficiency of osthole.…”

Section: Model Fittingcontrasting

confidence: 55%

Optimization of Process Parameters of Osthole-Loaded PLGA Microparticles Prepared Using Emulsification–Solvent Extraction

Liu

Chang

2014

Journal of Dispersion Science and Technology

View full text Add to dashboard Cite

Osthole-loaded poly(d,l-lactic-co-glycolic) acid (PLGA) microparticles were prepared by oil-inwater (o/w) emulsification. The organic phase in emulsions was extracted by conventional evaporation and supercritical fluid extraction of emulsions. A Box-Behnken experimental design was used to evaluate the effects and to optimize the variables. Results indicated that the effects from two variables, that is, the emulsification stirring speed and the ratio of osthole to PLGA, had statistically significant on the encapsulation efficiency, while another variable, that is, the volume ratio of o/w, has no independent impact on the encapsulation. The interactions exist between the ratio of osthole to PLGA and the stirring speed, and between the volume ratio of o/w and the stirring speed. A second-order polynomial model was well adjusted to predict response variables, and 90.9% encapsulation efficiency could be realized at optimized conditions. The encapsulation efficiency of microparticles obtained with conventional evaporation was higher than that with supercritical fluid extraction of emulsions. The release curve of osthole from the microparticles could be nicely fitted by the Weibull equation and the release follows Fickian diffusion.

show abstract

“…However, due to the hydrophobic character of daidzein and PHBV, only a small amount of the encapsulated daidzein will agglomerate toward the microsphere surface during the intense solvent evaporation. 27 It is found from the drug release profile that the initial drug burst release is relatively low (B10% after 1 h) and a subsequent sustained drug release (over 336 hours) was obtained. It can be concluded that daidzein molecules were mainly entrapped inside the PHBV microsphere matrix leading to sustained release.…”

Section: Daidzein Release Profilesmentioning

confidence: 98%

“…It is well-known that the morphology and size distribution of microspheres have a significant influence on their drug release profiles. 27 The relative rough surface topography of daidzein-loaded PHBV microspheres in Fig. 3 could be further optimized to achieve a comparable surface morphology to daidzein-free microspheres.…”

Section: Morphology and Size Distribution Of Phbv Microspheresmentioning

confidence: 99%

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Chen

Yao

et al. 2016

J. Mater. Chem. B

View full text Add to dashboard Cite

The development of drug delivery coating systems for local and long-term drug release is gaining increasing interest especially to functionalize bioinert implants with osseointegration and antibacterial properties. In this study, a biodegradable drug delivery coating platform consisting of drug-loaded PHBV microspheres embedded in an alginate-PVA matrix was fabricated by a one-step electrophoretic deposition (EPD) process. Layer by layer (LbL) deposition was exploited to generate chitosan-alginate multilayers on the EPD-produced coating to enlarge the diffusional barrier around the microspheres for controlled drug release. Daidzein, selected as a model drug due to its anti-osteoporosis properties, was pre-encapsulated in PHBV microspheres. The parameters for microsphere fabrication were optimized by an orthogonal design approach. The loading efficiency of daidzein in both the microspheres and in the deposited coatings was adjusted by varying the processing parameters during microsphere fabrication and the EPD process. The degradation of the deposited multilayers was investigated in PBS for up to 14 days. The degradation rate, surface roughness and wettability, as well as adhesion strength of the coatings during degradation were evaluated by applying a range of techniques. A controlled and sustained daidzein release was detected from both free microspheres and microsphere-containing coatings. Finally cytotoxicity and stimulatory effects of daidzein or daidzein-loaded coatings, on both MC3T3-E1 and RAW264.7 cell lines, were studied to validate the potential of the developed coatings for orthopedic applications.

show abstract

Microencapsulation par évaporation de solvant

Cited by 25 publications

References 24 publications

Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy

Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy

Optimization of Process Parameters of Osthole-Loaded PLGA Microparticles Prepared Using Emulsification–Solvent Extraction

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Contact Info

Product

Resources

About