Microencapsulation: Solvent evaporation

Ahangaran, Fatemeh

doi:10.1016/b978-0-323-85947-9.00016-9

Cited by 4 publications

(9 citation statements)

References 56 publications

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“…All assays were performed in triplicate. The encapsulation efficiency was calculated by using the following equation E E false( % false) = false( normalt normalo normalt normala normall 0.25em normald normalr normalu normalg 0.25em normala normald normald normale normald − normalf normalr normale normale 0.25em normald normalr normalu normalg false) normalt normalo normalt normala normall 0.25em normald normalr normalu normalg 0.25em normala normald normald normale normald × 100 % …”

Section: Methodsmentioning

confidence: 99%

“…All assays were performed in triplicate. The encapsulation efficiency was calculated by using the following equation 32 …”

Section: Methodsmentioning

confidence: 99%

“…The acylation process involves the reaction of depolymerized chitosan with stearoyl chloride under mild conditions, which is facilitated by an acidic environment that enhances the rate of acylation. The optimal formulation of stearoyl chitosan was employed to encapsulate antimetabolites using the solvent evaporation–hydration technique . Therefore, the objective of this work was to assess the most stable formulation of stearoyl chitosan based on its physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

“…The optimal formulation of stearoyl chitosan was employed to encapsulate antimetabolites using the solvent evaporation–hydration technique. 32 Therefore, the objective of this work was to assess the most stable formulation of stearoyl chitosan based on its physicochemical properties. Additionally, the incorporation of antimetabolite into the selected stearoyl chitosan was investigated by analyzing the encapsulation efficiency, particle size, ζ-potential, morphology, and in vitro release.…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan

Marlina,

Misran

2023

ACS Omega

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Stearoyl chitosan (SC), derived from the acylation of chitosan, contributes to the efficiency of drug delivery systems because of its structure, which accommodates the drug in a particle. Nonetheless, its role in chemotherapy has been largely unexplored. The present study involves the synthesis of stearoyl chitosan through the reaction of depolymerized chitosan with stearoyl chloride under mild reaction conditions. The resulting compound was subjected to structural analysis utilizing Fourier-transform infrared (FTIR) spectroscopy, 1H NMR, and X-ray diffraction (XRD) spectroscopy. The dispersion of SC molecules in phosphate-buffered saline (PBS) forms SC nanoparticles. The best dispersion of SC in the solution was achieved at a 1:60 chitosan-to-stearoyl chloride weight ratio. Three antimetabolite drugs, methotrexate, pemetrexed, and raltitrexed, were selected to examine the loading efficacy of SC. Pemetrexed had the highest drug-loading value of 36.8% among the three antimetabolites incorporated into SC, along with an encapsulation efficiency of 85.1%. The size of SC loaded with antimetabolites ranged from 225 to 369 nm, and their spherical form was verified via a transmission electron microscope. The in vitro release study showed that SC demonstrated controlled drug release, suggesting that SC nanoparticles have significant promise as a delivery strategy for chemotherapy.

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Section: Methodsmentioning

confidence: 99%

“…All assays were performed in triplicate. The encapsulation efficiency was calculated by using the following equation 32 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan

Marlina,

Misran

2023

ACS Omega

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“…There are several microencapsulation methods, including spray-drying, spray-congealing, freeze-drying, solvent evaporation, coacervation, and interfacial polymerization. This study uses the solvent evaporation method by which the active substance is suspended in a polymer solution containing an anhydrous organic solvent and then evaporated (Ahangaran, 2022).…”

Section: Introductionmentioning

confidence: 99%

Capsule Dosage Forms Containing Natural Antioxidant Microcapsules of Cantigi Extract

Kosasih,

Weningtyas

2024

Preprint

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Microencapsulation technology in product development of the food, beverage, and health sectors may provide innovative products with better stability, functionality, and prolonged releases. This study aims to formulate capsule dosage forms containing natural antioxidant microcapsules of Cantigi extract and analyze slow-release profiles. Three microcapsule formulations (F1, F2, and F3) were made by solvent evaporation method using ethyl cellulose coating and characterized for color, odor, particle size, shape, recovery, moisture content, encapsulation efficiency, drug loading, density, and antioxidant activities. Then, three capsule dosage forms (FI, FII, and FIII) of microcapsules of the most potent antioxidant activity, microcrystalline cellulose, and colloidal silicon dioxide. The results showed that the most potent microcapsules were F1, while the most potent capsule dosage forms were FIII. FIII provides the slowest release compared with FI and FII. By analyzing the kinetics of FIII using zero-order, first-order, Higuchi, and Kosmeyer-Peppas models, the release profile of FIII is the best fit with the first-order model kinetics, consistent with a previous study. Moreover, all capsule dosage forms have a biphasic slow-release profile for 60 minutes. The conclusion is that this study can prepare hard-gelatin capsule dosage forms containing natural antioxidant microcapsules of cantigi extract with first-order and biphasic slow-release profiles.

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Model Optimization and Characterization of Epoxy and Amine Microcapsules as Dual Self-Healing Mechanism

Akorede,

Adeyemi,

Ado

et al. 2024

Chemistry Africa

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Microencapsulation: Solvent evaporation

Cited by 4 publications

References 56 publications

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan

Capsule Dosage Forms Containing Natural Antioxidant Microcapsules of Cantigi Extract

Model Optimization and Characterization of Epoxy and Amine Microcapsules as Dual Self-Healing Mechanism

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