Microencapsulation using Poly(L-Lactic Acid) I: Microcapsule Properties Affected by the Preparative Technique

Jalil, Reza-ul; Nixon, J. R.

doi:10.3109/02652048909031167

Cited by 79 publications

(24 citation statements)

References 18 publications

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“…The method depends on the formation of an emulsion system initially and then the evaporation of the solvent used in the inner phase. Considering the solubility of the drug and polymer, there are principally two systems from which to choose: water-in-oil (w/o) or oil-in-water (o/w) (Huang and Ghebre-Sellassie, 1989;Jalil and Nixon, 1989). In the present study, w/o system was chosen since IND and PMMA are soluble in acetone, a water-miscible solvent.…”

Section: Entrapment Efficiency and Recoverymentioning

confidence: 99%

Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies

Yüksel

Baykara

Shirinzade

et al. 2011

International Journal of Pharmaceutics

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Section: Entrapment Efficiency and Recoverymentioning

confidence: 99%

Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies

Yüksel

Baykara

Shirinzade

et al. 2011

International Journal of Pharmaceutics

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“…biodegradable polymers such as polylactic acid, polyglycolic acids and polylactic-co-glycolic acid [15,16]. These microspheres, however, are not ideal as their degradation products have been observed to cause an inflammatory response [4,5].…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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Controlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspheres were remarkably different from those of sol gel granules produced by grinding and sieving. In contrast to a fast, short-term release from granules, the release from microspheres was slower and of longer duration. In addition, the degradation rate of microspheres was significantly slower than that of the granules. Using various mathematical models, the data reveal that the release from sol gel powder is governed by two distinct phases of release. In addition, the release from emulsified microspheres is delayed, a finding that can be attributed to differences in surface properties of the particles produced by emulsification and those produced by casting and grinding. The presented results represent an excellent data set for designing and implementing preclinical studies. t r a c tControlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspher...

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“…Preparation of ethyl cellulose microcapsule: EC microcapsules containing SS were prepared using the emulsification and organic solvent evaporation technique (Jalil et al, 1989). Acetone was used as polymer solvent, light liquid paraffin (LLP) as the microcapsulating vehicle and n-hexane as the decanter of paraffin oil.…”

Section: Methodsmentioning

confidence: 99%

Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose Microcapsules using Emulsion Solvent Evaporation Technique

et al. 2015

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Ethyl cellulose (EC) microcapsules containing Salbutamol sulphate (SS) were prepared through emulsion-solvent evaporation technique. Microcapsules were compressed and in-vitro release profiles were studied from both microcapsules and their compressed matrix tablets. Different amounts of drug were added in order to obtain various drugs to polymer ratios and it was found that the size of microcapsules reduced with the increase in core loading. In the preparation of formulations, Tween 80 was used as an emulsifying or dispersing agent and light liquid paraffin (LLP) was used as oil phase. The in-vitro release of EC microcapsules was studied in distilled water at 37º ± 0.5°C. A biphasic release behavior of SS from microcapsules was observed. In case of microcapsules, an immediate release was observed but for their compressed tablet form, initially a burst effect and then slow release were observed which was extended for 8 hours. In order to further investigate the type of drug release mechanism, the dissolution data were plotted according to the different kinetic models. In-vitro dissolution studies showed that zero-order and square-root of time (Higuchi model) release characteristics were exhibited.

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Microencapsulation using Poly(L-Lactic Acid) I: Microcapsule Properties Affected by the Preparative Technique

Cited by 79 publications

References 18 publications

Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies

Investigation of triacetin effect on indomethacin release from poly(methyl methacrylate) microspheres: Evaluation of interactions using FT-IR and NMR spectroscopies

The controlled release of drugs from emulsified, sol gel processed silica microspheres

Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose Microcapsules using Emulsion Solvent Evaporation Technique

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