Microenvironment-triggered multimodal precision diagnostics

Impact of cancer metabolism on therapy resistance – Clinical implications

“…Importantly, this strategy has been shown to outcompete conventional FDG-based PET imaging by showing clear detection of occult malignant in tumor-bearing mice while reducing false positive detection rates of inflammation in non-cancerous mouse models. Similar observations have been made with a pH-dependent peptide pHLIP that allows the specific release of the 64 Cu radiotracer in acidic (tumor) tissues and the detection of primary and metastatic lesions in mouse models of CRC (Hao et al, 2021). In this study, the authors have also reported that this approach can monitor the therapeutic response to 5-FU, a standard chemotherapy for CRC.…”

Conjugated polymers for biomedical applications

“…Human beings have suffered from serious diseases, like cancers and cardiovascular diseases for centuries. [1][2][3] Numerous techniques in the disciplines of precision diagnostics, 4,5 targeted therapy, 6,7 intraoperative imaging 8,9 and postoperative evaluation 10,11 have been developed and applied to improve disease outcomes. The rapid development of exceptional materials is critical to new technology innovation in the biomedical field.…”

A K+-sensitive AND-gate dual-mode probe for simultaneous tumor imaging and malignancy identification

“…By rationally integrating different imaging agents, nanoprobes can be tailored to have versatile properties for multimodal imaging, which could compensate for the weaknesses of each imaging modality [ 1 , 16 , 17 ]. FI brings the capability to identify tumor-associated biomarkers with high sensitivity [ 18–20 ].…”