Microextraction columns for automated sample preparation. A review focusing on fully miniaturized column switching and bioanalytical applications

Medina, Deyber Arley Vargas; Sartore, Douglas Morisue; Maciel, Edvaldo Vasconcelos Soares; Neto, Álvaro José dos Santos; Lanças, Fernando Mauro

doi:10.1016/j.sampre.2022.100031

Cited by 4 publications

(5 citation statements)

References 111 publications

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“…Sample preparation is often a critical first step in the analysis of complex samples in a variety of matrices. Recently, efforts have been made to automate sample preparation techniques to improve method throughput and reproducibility [20][21][22]. Frequently, microcontrollers are used to control the movement systems associated with these automated sample preparation techniques [23], especially in connection with open-source stepper motor driver boards (e.g., the RepRap Arduino Mega Pololu Shield, or RAMPS, board).…”

Section: Sample Preparationmentioning

confidence: 99%

The utilization of open‐source microcontroller boards and single‐board computers in liquid chromatography

Piccolo,

Foster,

Parker

et al. 2024

J of Separation Science

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Electronic system control of analytical instrumentation remains a critical aspect of modern measurement science. Within the field of liquid chromatography (LC), this is especially relevant for automation, module operation, detection, data acquisition, and data analysis. Increasingly, home‐built analytical tools used for liquid‐phase separations rely upon open‐source microcontrollers and single‐board computers to aid in simplifying these operations. In this review, we detail literature reported within the past 5 years in which these types of devices were used to advance various aspects of the LC research field, including sample preparation, instrument control, and data collection.

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Section: Sample Preparationmentioning

confidence: 99%

The utilization of open‐source microcontroller boards and single‐board computers in liquid chromatography

Piccolo,

Foster,

Parker

et al. 2024

J of Separation Science

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“…Research using OT columns as extraction/preconcentration columns (first dimension) in column-switching methods has significantly developed new coatings to retain many analytes [133]. For example, Kataoka et al [134] reported the use of PLOT columns (60 cm × 0.32 mm i.d.)…”

Section: Application Of Ot Columns In Column-switching Lcmentioning

confidence: 99%

“…In general, the diversity of OT coatings for extractive purses superates the ones employed in analysis and separation, possibly due to the short length of the extractive columns, which facilitates its preparation. Critical reviews have recently been introduced summarizing the vast diversity of OT coatings for extractive porpuses [133,[137][138][139][140][141]. Table 2 shows some selected examples of diverse coating and its potential to retain analytes in a broad polarity range.…”

Section: Application Of Ot Columns In Column-switching Lcmentioning

confidence: 99%

Open tubular liquid chromatography: Recent advances and future trends

Medina

Cardoso

Borsatto

et al. 2023

J of Separation Science

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Nano‐liquid chromatography (nanoLC) is gaining significant attention as a primary analytical technique across various scientific domains. Unlike conventional high‐performance LC, nanoLC utilizes columns with inner diameters (i.ds.) usually ranging from 10 to 150 μm and operates at mobile phase flow rates between 10 and 1000 nl/min, offering improved chromatographic performance and detectability. Currently, most exploration of nanoLC has focused on particle‐packed columns. Although open tubular LC (OTLC) can provide superior performance, optimized OTLC columns require very narrow i.ds. (< 10 μm) and demand challenging instrumentation. At the moment, these challenges have limited the success of OTLC. Nevertheless, remarkable progress has been made in developing and utilizing OTLC systems featuring narrow columns (< 2 μm). Additionally, significant efforts have been made to explore larger columns (10–75 μm i.d), demonstrating practical applicability in many situations. Due to their perceived advantages, interest in OTLC has resurged in the last two decades. This review provides an updated outlook on the latest developments in OTLC, focusing on instrumental challenges, achievements, and advancements in column technology. Moreover, it outlines selected applications that illustrate the potential of OTLC for performing targeted and untargeted studies.

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“…Therefore, studies employing direct and indirect determination methods for pesticide exposure have been conducted (16), with human biomonitoring enabling the measurement of personal exposure to specific chemicals, including both unmetabolized and metabolized compounds (17). This is typically achieved through the analysis of biological samples like blood, plasma, serum, and urine, frequently complemented with oral fluid, hair, and nails, employing methods that must be fast, sensitive, and specific, emphasizing miniaturization and automation (18,19). Technological advancements have led to increasingly sensitive detection methods capable of measuring pesticides accurately in parts per billion (ng•mL −1 , or μg•kg −1 ), even with less expensive instrumentation and simplified approaches (20).…”

Section: Introductionmentioning

confidence: 99%

“…This is typically achieved through the analysis of biological samples like blood, plasma, serum, and urine, frequently complemented with oral fluid, hair, and nails, employing methods that must be fast, sensitive, and specific, emphasizing miniaturization and automation ( 18 , 19 ). Technological advancements have led to increasingly sensitive detection methods capable of measuring pesticides accurately in parts per billion (ng·mL −1 , or μg·kg −1 ), even with less expensive instrumentation and simplified approaches ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Birolli,

Lanças,

dos Santos Neto

et al. 2024

Front. Public Health

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IntroductionPollution has emerged as a significant threat to humanity, necessitating a thorough evaluation of its impacts. As a result, various methods for human biomonitoring have been proposed as vital tools for assessing, managing, and mitigating exposure risks. Among these methods, urine stands out as the most commonly analyzed biological sample and the primary matrix for biomonitoring studies.ObjectivesThis review concentrates on exploring the literature concerning residual pesticide determination in urine, utilizing liquid and gas chromatography coupled with mass spectrometry, and its practical applications.MethodThe examination focused on methods developed since 2010. Additionally, applications reported between 2015 and 2022 were thoroughly reviewed, utilizing Web of Science as a primary resource.SynthesisRecent advancements in chromatography-mass spectrometry technology have significantly enhanced the development of multi-residue methods. These determinations are now capable of simultaneously detecting numerous pesticide residues from various chemical and use classes. Furthermore, these methods encompass analytes from a variety of environmental contaminants, offering a comprehensive approach to biomonitoring. These methodologies have been employed across diverse perspectives, including toxicological studies, assessing pesticide exposure in the general population, occupational exposure among farmers, pest control workers, horticulturists, and florists, as well as investigating consequences during pregnancy and childhood, neurodevelopmental impacts, and reproductive disorders.Future directionsSuch strategies were essential in examining the health risks associated with exposure to complex mixtures, including pesticides and other relevant compounds, thereby painting a broader and more accurate picture of human exposure. Moreover, the implementation of integrated strategies, involving international research initiatives and biomonitoring programs, is crucial to optimize resource utilization, enhancing efficiency in health risk assessment.

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Microextraction columns for automated sample preparation. A review focusing on fully miniaturized column switching and bioanalytical applications

Cited by 4 publications

References 111 publications

The utilization of open‐source microcontroller boards and single‐board computers in liquid chromatography

The utilization of open‐source microcontroller boards and single‐board computers in liquid chromatography

Open tubular liquid chromatography: Recent advances and future trends

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

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