Microextraction of non-steroidal anti-inflammatory drugs from waste water samples by rotating-disk sorptive extraction

Manzo, Valentina; Honda, Luis; Navarro, Orielle; Ascar, Loreto; Richter, Pablo

doi:10.1016/j.talanta.2014.06.003

Cited by 67 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extraction device used in RDSE contains a cavity into which the sorptive phase is loaded to extract the analyte from complex samples. 13,14 By following this approach, in this work, we demonstrated that this extraction platform is equally applicable for determination of TCB as its metabolites sulphone and sulphoxide in cattle plasma. This method results in a greener and simpler alternative compared with methods based on SPE.…”

Section: -8mentioning

confidence: 91%

“…Taking into account our previous experiences in RDSE procedures, 13,14,18,19 the rotation velocity of the disk was kept at 2000 rpm, and all the optimization was made in absence of matrix modifiers. Rotation velocity was kept at the maximum velocity achieved by the magnetic stirrer, because under this condition the boundary layer formed on the surface of the sorptive phase decreases and analyte mass transfer is faster.…”

Section: Optimization Of Variablesmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Cañas-Müller

Campo

Richter

2016

J. Chil. Chem. Soc.

Self Cite

View full text Add to dashboard Cite

In this study, a new method for determination of triclabendazole (TCB) as its main metabolites, triclabendazole sulfoxide (TCB-SO) and triclabendazole sulfone (TCB-SO 2 ) in animal plasma was developed. TCB is widely used as antiparasitic in the veterinary industry. Rotating disk sorptive extraction (RDSE) was the selected sample preparation technique for extraction/clean up of the compounds from the samples followed by high performance liquid chromatography coupled to diode array detection (HPLC-DAD) for quantification.Optimization of physicochemical variables was performed using a multivariate experimental design. Following the recommendations given in the Veterinary International Conference on Harmonization guides (VICH GL02 and VICH GL49), the validation of the method was performed, given rise to improved analytical features compared with those provided by other methods based on solid phase extraction (SPE). Linearity (r > 0.99) was achieved for both compounds when calibration was performed not only in standard solutions but also in animal spiked plasma. Selectivity, defined as the response ratio between blank and analyte at the limit of quantification, was 11.8% and 3.4% for TCB-SO and TCB-SO 2 , respectively. Accuracy and precision, expressed in percentage, were always lower than -16.7% and 8.1%, respectively. Eco-efficiency was quantitatively assessed indicating that the method is an excellent green method.The proposed analytical method was applied to the determination of the pharmacokinetic of two commercial products of TCB in cattle plasma after oral administration.The good analytical performance, eco-efficiency and economy, make the method interesting for alternative use in routine laboratories.

show abstract

Section: -8mentioning

confidence: 91%

Section: Optimization Of Variablesmentioning

confidence: 99%

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Cañas-Müller

Campo

Richter

2016

J. Chil. Chem. Soc.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Human pharmaceuticals, including NSAIDs, are ubiquitous in the environment (Kümmerer, 2010) and found in the ng to mg L À 1 range in water (Es'haghi, 2009;Kosjek et al, 2005;Manzo et al;Santos et al, 2010) and up to low mg kg À 1 in soils (Aznar et al, 2014;Butler et al, 2012;Dalkmann et al, 2012;Durán-Alvarez et al, 2009;Golet et al, 2003;Kinney et al, 2006;Redshaw et al, 2008a;Vazquez-Roig et al, 2010). Human pharmaceuticals can be transported to the environment via drug disposal, excretion of parent compounds and metabolites, and subsequent passage through wastewater treatment plants (WWTPs) (Stahl-Timmins et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biological endpoints in crop plants after exposure to non‐steroidal anti‐inflammatory drugs (NSAIDs): Implications for phytotoxicological assessment of novel contaminants

Schmidt

Redshaw

2015

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

“…Many authors have published research papers and reviews [20,28,29] on this topic. Wastewaters are the most studied branches [30][31][32][33][34][35], followed by surface [36][37][38][39][40] and drinking waters [41,42], while gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) are the techniques of election. Only a small part of literature has been dedicated to groundwater, especially in the past years [43,44].…”

Section: Introductionmentioning

confidence: 99%

Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry

Rocca

Gentili

Caretti

et al. 2015

International Journal of Environmental Analytical Chemistry

View full text Add to dashboard Cite

Non-steroidal anti-inflammatory drugs (NSAIDs) are considered to be the cure-all of any pain: from headache and cold symptoms to toothaches and even labour pain. Their wide use in human medicine has been favoured by the possibility to purchase them without medical prescription, their low cost and by the absence of opioid-like side effects. At the same time, their administration to domestic and food-producing animals has become a common practice to improve their well-being. Therefore, human and veterinary applications are the main sources of NSAIDs in the environment and the major pathways are excretion and discharge through sewage treatment plants. Although their environmental occurrence is well-known, there is a lack of data regarding their levels in surface waters of Central Italy. In this study, a monitoring campaign was arranged in some of the most important rivers and lakes of Central Italy, characterised by a different anthropic impact, in spring-summer and autumn-winter 2012. A broad range of NSAIDs for human and animal use was analysed through a reliable analytical method based on liquid chromatography-tandem mass spectrometry, appropriately developed and validated. Results have shown the constant presence of all drugs commonly used in human medicine with a composition that mirrored the incidence of seasonal diseases quite well. A veterinary drug (flunixin) was found in Bracciano Lake (Rome district), an important tourist attraction surrounded by farmlands. Salicylic acid is a phytohormone and this explains its presence in all the analyzed samples. All the results collected during the extensive survey have proved that Central Italy is aligned with the rest of Europe since its natural waters have shown low levels of contamination (ngL(-1)) but with a chronic input

show abstract

Microextraction of non-steroidal anti-inflammatory drugs from waste water samples by rotating-disk sorptive extraction

Cited by 67 publications

References 41 publications

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Evaluation of biological endpoints in crop plants after exposure to non‐steroidal anti‐inflammatory drugs (NSAIDs): Implications for phytotoxicological assessment of novel contaminants

Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry

Contact Info

Product

Resources

About