Microfabricated protein-containing poly(ethylene glycol) hydrogel arrays for biosensing

Multianalyte sensor array based on an organic light emitting diode platform

“…Multianalyte detection in a single sample using sensor arrays of various designs and sizes has been studied extensively with a range of transduction mechanisms, including electrochemical [1][2][3], piezoelectric [4], electrical resistance [5,6], and optical [7][8][9][10][11][12][13][14][15][16][17][18][19]. Such studies are driven by the need for high throughput, inexpensive, and efficient analyses of complex samples in a broad range of applications, such as medical, biological (including biodefense), environmental, and industrial (e.g., the food and beverage industry).…”

Development of acetylcholinesterase biosensor based on CdTe quantum dots modified cysteamine self-assembled monolayers

“…Unfortunately, at the present time there is no ideal immobilization method generally usable for all enzymes. Therefore, many immobilization methods and different materials have been employed to fabricate enzymebased biosensors, including direct physical adsorption onto a solid support [6] encapsulation into a hydrogel [7], cross-linking [8] and covalent binding [9]. A key requirement of enzyme immobilization is attachment without the bioactivity being sacrificed.…”

Enhanced mixing in polyacrylamide gels containing embedded silica nanoparticles as internal electroosmotic pumps

“…The designs of biosensor devices often call for biomolecular recognition elements, such as enzymes, antibodies, or oligonucleotides, to be immobilized in or on a substrate [1][2][3][4][5][6][7][8][9]. Immobilization in hydrogels is commonly used to protect the sensing elements in applications involving exposure to fouling environments [10,11].…”