In this chapter we briefly review the techniques available to researchers in the nanofluidic domain to fabricate nanopores and nanochannels. In this context the focused ion beam (FIB) technique will be introduced as a useful and versatile tool for nanofluidics. We illustrate it with two specific examples involving nanopores as building blocks for nanofluidics.
IntroductionNanofluidics is an emerging topic that has come into its own quite recently from the more established field of microfluidics. Nanofluidics is a branch of nanoscience and has great potential for numerous applications such as biotechnological devices [1], fluidic operations, and even energy conversion [2]. From the point of view of "lab on a chip" systems, decreasing the length scale considerably increases the sensitivity of analytic techniques, with the ultimate goal being isolating and studying individual macromolecules (e.g., DNA elongation [3], DNA capture [4]). Moreover, nanometric length scales allow new fluidic functionalities to be developed, which benefit from the predominance of surface sites: water desalination [5], pre-concentration phenomena [6], nanofluidic transistors [7], as well as capillary filling.