Microfiber assisted fabrication of microfluidic channels using poly(dimethylsiloxane)

Huang, Tom T.; Chang, Woojin; Akin, Demir; Gómez, Rafael; Bashir, Rashid; Mosier, Nathan S.; Ladisch, Michael R.

doi:10.1002/aic.690491129

Cited by 6 publications

(7 citation statements)

References 11 publications

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“…Nonetheless, it was determined that this roughness issue could be mitigated by annealing a transparency sheet against the printed mold and using the annealed, smoothed sheet as the primary mold for PDMS. A similar approach for creating PDMS-based devices has been employed successfully by others (Huang et al 2003).…”

Section: Introductionsupporting

confidence: 41%

Behavior of capillary valves in centrifugal microfluidic devices prepared by three-dimensional printing

Moore

McCuiston

Mittendorf

et al. 2010

Microfluid Nanofluid

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This paper details the behavior of capillary valves in centrifugal microfluidic devices prepared by three-dimensional (3D), or solid-object, printing. Microfluidic structures containing valve channels with different widths, heights, and radial distances from the center of rotation were studied and compared with extant capillary valve theories. Due to the printing process, the produced valve channels possessed a ridged or ''scalloped'' pattern. Hence, actual channel widths at the widest and narrowest points of the ridged pattern were determined, and used in comparisons between theoretical and empirical values. In addition, variations in contact angle resulting from the ridged pattern were measured and employed in theoretical calculations. For 1-mm high valve channels, the critical angular frequency (rpm) required to overcome capillary valve pressure was found to be independent of width. However, as the height of the valve channel was reduced, the critical rpm was found to become progressively more width-dependent increasing more rapidly for narrower channels. Both of these observations point to a role for feature sharpness, as well as the geometry of the valve channel opening, in valve behavior. Otherwise, valves followed a predictable trend of increasing critical rpm with decreased valve height and decreased radial distance from the rotation center. Using these results as a guide, then, it is possible to prepare centrifugal microfluidic devices by 3D printing with operability comparable to devices prepared by other microfabrication techniques.

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Section: Introductionsupporting

confidence: 41%

Behavior of capillary valves in centrifugal microfluidic devices prepared by three-dimensional printing

Moore

McCuiston

Mittendorf

et al. 2010

Microfluid Nanofluid

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“…Proof of concept of the press-fit microdevice is provided by microchannels created with glass wool fiber [14]. Positively charged DMA microbeads (0.8 lm) and streptavidin-coated PS microbeads (0.8 lm) immobilized on the fiber enabled the development of a functional microfluidic device for separation of target biological species.…”

Section: Press-fit Microdevicessupporting

confidence: 39%

“…The underlying importance of surface chemistries in microfluidic devices and the significance of using press-fit techniques for fabricating microdevices with engineered surface chemistries are presented. This press-fit technique uses a microfiber such as glass wool fiber (l12 lm diameter) placed on a substrate and press-fitted with a flexible elastomer, PDMS to form microfluidic flow channels in less than an hour [14]. The microfiber can serve the dual functions of forming a microchannel with PDMS and also containing desired surface chemistries for acting as a solid phase for separation [14], as well as a stationary object for directing boundary-layer flow [15].…”

Section: Introductionsupporting

confidence: 41%

“…Fiber-assisted fabrication using the press-fit method [14] accomplishes a patterned surface in a single step by sandwiching a hydrophilic microfiber between two hydrophobic surfaces (i. e., PDMS and ODS wafer). The microfiber has the dual purposes of creating microchannels with PDMS and also patterning the surface free energies inside these channels [15].…”

Section: Fiber-directed Boundary Layer Flowmentioning

confidence: 49%

“…This press-fit technique uses a microfiber such as glass wool fiber (l12 lm diameter) placed on a substrate and press-fitted with a flexible elastomer, PDMS to form microfluidic flow channels in less than an hour [14]. The microfiber can serve the dual functions of forming a microchannel with PDMS and also containing desired surface chemistries for acting as a solid phase for separation [14], as well as a stationary object for directing boundary-layer flow [15]. The resulting microfiber-directed boundary flow provides fundamental insights on how surface forces might be manipulated inside a hydrophobic microchannel to obtain desirable flow patterns.…”

Section: Introductionmentioning

confidence: 48%

See 2 more Smart Citations

Surface engineering of microchannel walls for protein separation and directed microfluidic flow

Huang

Mosier

Ladisch

2006

J of Separation Science

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The preparation of surfaces in microfluidic devices that selectively retain proteins may be difficult to implement due to the incompatibility of derivatization methods with microdevice fabrication techniques. This review describes recently reported developments in simple and rapid methods for engineering the surface chemistries of microchannels based on construction of press-fit microdevices. These devices are fabricated by placing a glass fiber on a PDMS film and pressing the film on a silicon wafer or a microscope slide that has been derivatized with octadecyltrichlorosilane (ODS). The film adheres to the slide and forms an elliptically shaped channel around the fiber. The combination of surface wettability of a hydrophilic glass microfiber and the surrounding hydrophobic microchannel surfaces directs a narrow boundary layer of liquid next to the fiber in order to bring the sample in contact with the separation media and results in selective retention of proteins. This phenomenon may be exploited to enable microscale separation applications since there are a wide variety of fibers available with different chemistries. These may be used to rapidly fabricate microchannels that serve as stationary phases for separation at a microscale. The fundamental properties of such devices are discussed.

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Membrane for selective capture of the microbial pathogen Listeria monocytogenes

et al. 2005

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Microfiber assisted fabrication of microfluidic channels using poly(dimethylsiloxane)

Cited by 6 publications

References 11 publications

Behavior of capillary valves in centrifugal microfluidic devices prepared by three-dimensional printing

Behavior of capillary valves in centrifugal microfluidic devices prepared by three-dimensional printing

Surface engineering of microchannel walls for protein separation and directed microfluidic flow

Membrane for selective capture of the microbial pathogen Listeria monocytogenes

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